Very Prolonged Treatment with Albendazole of a Case of Disseminated Abdominal Cystic Echinococcosis

Cystic echinococcosis is a zoonosis caused by the ingestion of food or water contaminated by Echinococcus eggs. E. granulosus is the most common causative agent of cystic echinococcosis that still has a relevant incidence in Italy, especially on the islands of Sicily and Sardinia. We report the case of a 64-year-old man with disseminated abdominal cystic echinococcosis (liver, spleen, peritoneum). The patient was asymptomatic and non-eligible for surgical treatment. Treatment with albendazole 400 mg/twice daily was started in 2012 for 15 cycles (each cycle consisted of three 28-day treatments at 14-day intervals) over 10 years for a total of 1260 days of treatment. Serum anti-Echinococcus antibody titers and imaging (echography, TC) were evaluated to monitor the evolution of the disease. Imaging techniques documented the regression of all cyst lesions, but it was less evident for the peritoneal localizations that still are in follow-up. In this case, the prolonged treatment with albendazole was effective, safe and free of side effects. Until today, the patient displays a good clinical condition

Towards a unified approach to information-disturbance tradeoffs in quantum measurements

We show that the global balance of information dynamics for general quantum measurements given in [F. Buscemi, M. Hayashi, and M. Horodecki, Phys.Rev.Lett. 100, 210504 (2008)] makes it possible to unify various and generally inequivalent approaches adopted in order to derive information-disturbance tradeoffs in quantum theory. We focus in particular on those tradeoffs, constituting the vast majority of the literature on the subject, where disturbance is defined either in terms of average output fidelity or of entanglement fidelity

Perioperative and anesthetic deaths: toxicological and medico legal aspects

Background: Anesthesia has become safer during decades, though there is still a preventable mortality; the complexity of medical and surgical interventions, increasingly older and sicker patients, has created a host of new hazards in anesthesiology. In this paper, some of these perioperative (PO) fatal adverse events are investigated in terms of health responsibility. Selective literature research in several data bases, concerning perioperative and anesthetic deaths and medical responsibility, was performed. Main text: A generally accepted definition of the anesthesia and perioperatory-related death still remains one of the major concerns in forensic pathology, and the terms “operative deaths” and “anesthetic deaths” are usually applied inaccurately within the medico-legal literature. Such events involve comprehensively PO fatalities and allow for subtle separation of natural and unnatural death, at least from the prospective of forensic pathology. Iatrogenic deaths in this field can be separated into some major categories, as attributable to previous patient’s unfavorable conditions or depending from surgical procedure per se (such as PO cardiac and cerebrovascular events). In this review, the authors carried out syntheses of specific research areas regarding epidemiology, complications of general and spinal anesthetic, failure in airway management and patient’s circulatory homeostasis, and adverse drugs reactions; analysis considering the challenge of anesthetic-related mortality, epidemiology and classifications, by indicating causal chain of death, in respect of both contributing and associated anesthetic and surgery facts. Conclusions: Perioperative quality control programs and its relevance for medico-legal evaluation are emphasized as, although mortality rates have decreased worldwide over the last decades, however, preventable drug-related deaths still happen. Such fatal events have to be considered within the field of forensic pathology experts, with regard of malpractice claims, to implement a strategy for preventing potentially fatal complications

Physical activity and cardiovascular prevention: Is healthy urban living a possible reality or utopia?

Favoring correct lifestyles is the most important measure to contrast cardiovascular diseases and the epidemic of high cardiovascular risk conditions, such as obesity, diabetes, and hypertension. Lifestyle is a broad expression that includes diet, physical exercise, and psychological and socio-economic factors, each of which must be taken into due consideration because of their intertwining influences, which may be a barrier to healthy changes at both the individual and population levels. While physical activity has probably received less attention in the last decades, it is likely the most important among the modifiable risk factors for cardiovascular diseases. Improving the habitual physical activity level is an achievable goal, and even small improvements may have important favorable effects on health. Strategies at the population level have to be urgently taken, and involve not only public health, but also administrators and politicians, starting from a rethinking of our cities

Superbroadcasting and classical information

We address the problem of broadcasting N copies of a generic qubit state to M>N copies by estimating its direction and preparing a suitable output state according to the outcome of the estimate. This semiclassical broadcasting protocol is more restrictive than a general one, since it requires an intermediate step where classical information is extracted and processed. However, we prove that a suboptimal superbroadcasting, namely broadcasting with simultaneous purification of the local output states with respect to the input ones, is possible. We show that in the asymptotic limit of $M \to \infty$ the purification rate converges to the optimal one, proving the conjecture that optimal broadcasting and state estimation are asymptotically equivalent. We also show that it is possible to achieve superbroadcasting with simultaneous inversion of the Bloch vector direction (universal NOT). We prove that in this case the semiclassical procedure of state estimation and preparation turns out to be optimal. We finally analyse semiclassical superbroadcasting in the phase-covariant case.Comment: 9 pages, 2 figure

A minimum-disturbing quantum state discriminator

We propose two experimental schemes for quantum state discrimination that achieve the optimal tradeoff between the probability of correct identification and the disturbance on the quantum state.Comment: 9 pages, 1 figure, OSID style. Submitted to the special issue of "Open Systems and Information Dynamics", Proceedings of the "38th Symposium on Mathematical Physics", Torun, Poland, June 200

Intraoperative measurement of parathyroid hormone: A Copernican revolution in the surgical treatment of hyperparathyroidism

Intraoperative parathyroid hormone (PTH) monitoring in the setting of the operating room represents a valuable example of the rationale use of the laboratory diagnostic in a patient-oriented approach. Rapid intraoperative PTH (ioPTH) assay is a valid tool for an accurate evaluation of the success of parathyroid surgery. The reliability of the user-friendly portable systems as well as the collaboration between operators and surgical staff allow the one-site monitoring of the ioPTH decrements on the course of the surgical management of hyperparathyroidism.The rapid answer provided by an effective decrement of PTH during parathyroidectomy contributes dramatically to the efficacy of parathyroid surgery and the reduction of the number of re-operations. Therefore the dose of ioPTH is a valid and reliable support for the success of the intervention of parathyroidectomy at controlled costs

Physical realizations of quantum operations

Quantum operations (QO) describe any state change allowed in quantum mechanics, such as the evolution of an open system or the state change due to a measurement. We address the problem of which unitary transformations and which observables can be used to achieve a QO with generally different input and output Hilbert spaces. We classify all unitary extensions of a QO, and give explicit realizations in terms of free-evolution direct-sum dilations and interacting tensor-product dilations. In terms of Hilbert space dimensionality the free-evolution dilations minimize the physical resources needed to realize the QO, and for this case we provide bounds for the dimension of the ancilla space versus the rank of the QO. The interacting dilations, on the other hand, correspond to the customary ancilla-system interaction realization, and for these we derive a majorization relation which selects the allowed unitary interactions between system and ancilla.Comment: 8 pages, no figures. Accepted for publication on Phys. Rev.