Exploring the Impact of Living with Fanconi Anaemia & Diamond-Blackfan Anaemia: A Systemic Consideration

Aims: Amidst a growing body of medical research, little is yet known about the psychological impact of living with two rare life-limiting conditions, Fanconi Anaemia (FA) and Diamond Blackfan Anaemia (DBA). One might expect some level of impact on well-being as indicated by wider literature on other childhood illnesses. At present, understanding of this impact is limited in being generalised from other research, as therefore are the supports available. This research seeks to begin a consideration of the psychological impact, and to consider how support has been deemed. Method: Using semi-structured interviews, parents and individuals living with FA or DBA were interviewed regarding their experiences. Thematic analysis was used to achieve an overview of these experiences. Results: Themes identified for individuals included: 1. ‘Knowledge’, which outlined the impact of lack of knowledge and 2. ‘Illness Concept’ relating to one’s relationship to FA/DBA and how this is socially mediated. For parents, themes identified were: 1. ‘Knowledge’, which centered on uncertainty and 2. ‘Social Responses’ which related to areas of support and strain. These themes indicated an impact on individual well-being. Two joint themes were identified: 1. ‘Family Dynamics’ which outlined how relationships and family well-being may be impacted and 2. ‘Mental Health Care as Necessary but Inadequate’. Conclusion: There was a clear impact articulated regarding the well-being of family members, individually and collectively in concerns regarding relational dynamics. There was also clear demand for psychological support which, in its current form, was generally considered inadequate. Research must be responsive in furthering efforts to establish clear and adequate pathways and a standard of care for the well-being of all families living with FA/DBA

Mean flow of turbulent–laminar patterns in plane Couette flow

A turbulent–laminar banded pattern in plane Couette flow is studied numerically. This pattern is statistically steady, is oriented obliquely to the streamwise direction, and has a very large wavelength relative to the gap. The mean flow, averaged in time and in the homogeneous direction, is analysed. The flow in the quasi-laminar region is not the linear Couette profile, but results from a non-trivial balance between advection and diffusion. This force balance yields a first approximation to the relationship between the Reynolds number, angle, and wavelength of the pattern. Remarkably, the variation of the mean flow along the pattern wavevector is found to be almost exactly harmonic: the flow can be represented via only three cross-channel profiles as U(x, y, z) ≈ U0(y) + Uc(y) cos(kz) + Us(y) sin(kz). A model is formulated which relates the cross-channel profiles of the mean flow and of the Reynolds stress. Regimes computed for a full range of angle and Reynolds number in a tilted rectangular periodic computational domain are presented. Observations of regular turbulent–laminar patterns in other shear flows – Taylor–Couette, rotor–stator, and plane Poiseuille – are compared

Symmetry breaking and turbulence in perturbed plane Couette flow

Perturbed plane Couette flow containing a thin spanwise-oriented ribbon undergoes a subcritical bifurcation at Re = 230 to a steady 3D state containing streamwise vortices. This bifurcation is followed by several others giving rise to a fascinating series of stable and unstable steady states of different symmetries and wavelengths. First, the backwards-bifurcating branch reverses direction and becomes stable near Re = 200. Then, the spanwise reflection symmetry is broken, leading to two asymmetric branches which are themselves destabilized at Re = 420. Above this Reynolds number, time evolution leads first to a metastable state whose spanwise wavelength is halved and then to complicated time-dependent behavior. These features are in agreement with experiments

Universal continuous transition to turbulence in a planar shear flow

We examine the onset of turbulence in Waleffe flow -- the planar shear flow between stress-free boundaries driven by a sinusoidal body force. By truncating the wall-normal representation to four modes, we are able to simulate system sizes an order of magnitude larger than any previously simulated, and thereby to attack the question of universality for a planar shear flow. We demonstrate that the equilibrium turbulence fraction increases continuously from zero above a critical Reynolds number and that statistics of the turbulent structures exhibit the power-law scalings of the (2+1)-D directed percolation universality class

Stability analysis of perturbed plane Couette flow

Plane Couette flow perturbed by a spanwise oriented ribbon, similar to a configuration investigated experimentally at the Centre d'Etudes de Saclay, is investigated numerically using a spectral-element code. 2D steady states are computed for the perturbed configuration; these differ from the unperturbed flows mainly by a region of counter-circulation surrounding the ribbon. The 2D steady flow loses stability to 3D eigenmodes at Re = 230, beta = 1.3 for rho = 0.086 and Re = 550, beta = 1.5 for rho = 0.043, where Re is the Reynolds number, beta is the spanwise wavenumber and rho is the half-height of the ribbon. For rho = 0.086, the bifurcation is determined to be subcritical by calculating the cubic term in the normal form equation from the timeseries of a single nonlinear simulation; steady 3D flows are found for Re as low as 200. The critical eigenmode and nonlinear 3D states contain streamwise vortices localized near the ribbon, whose streamwise extent increases with Re. All of these results agree well with experimental observations

Turbulent-laminar patterns in shear flows without walls

Turbulent-laminar intermittency, typically in the form of bands and spots, is a ubiquitous feature of the route to turbulence in wall-bounded shear flows. Here we study the idealised shear between stress-free boundaries driven by a sinusoidal body force and demonstrate quantitative agreement between turbulence in this flow and that found in the interior of plane Couette flow -- the region excluding the boundary layers. Exploiting the absence of boundary layers, we construct a model flow that uses only four Fourier modes in the shear direction and yet robustly captures the range of spatiotemporal phenomena observed in transition, from spot growth to turbulent bands and uniform turbulence. The model substantially reduces the cost of simulating intermittent turbulent structures while maintaining the essential physics and a direct connection to the Navier-Stokes equations. We demonstrate the generic nature of this process by introducing stress-free equivalent flows for plane Poiseuille and pipe flows which again capture the turbulent-laminar structures seen in transition.Comment: 13 pages, 9 figure

ADVANTAGES AND DISADVANTAGES OF TARGETING INDUSTRY CLUSTERS

Regional industrialization efforts include industrial recruitment, entrepreneurial and small business development, and business retention and expansion programs. Recently, many states and communities have targeted their industrialization programs at specific industries to promote the development of industry clusters. Broadly defined, an industry cluster is a loose, geographically bounded collection of similar and/or related firms that together create competitive advantages for member firms and the regional economy. The purpose of this paper is to summarize the debate concerning the advisability of industry cluster targeting as an employment generation strategy for states and sub-state regions. Our review of the appropriateness of a clusters strategy begins with a summary of industry cluster characteristics. Next we present the potential advantages developed clusters provide regional economies and the difficulties of establishing competitive clusters in new locations. We conclude with a summary of the implications of an industry clusters strategy for regional industrial development.Industrial Organization,

ESTIMATING THE COMMUNITY-LEVEL IMPACTS OF ATTRACTING NEW BUSINESSES: THE IMPLICATIONS OF LOCAL LABOR MARKET ADJUSTMENTS

The purpose of this report is to estimate short-and long-run labor market adjustments associated with employment change for South Carolina counties. An appreciation of the source of employees for new jobs enables community leaders to better select the appropriate level of industrial incentives and to better plan for changes in demand for public goods and services. We provide an overview of the components of a local labor force and the implications of component change on local income and expenditures for public goods and services. Then we present the results of the Clemson University Community Policy Analysis (CPAN) Model for county labor markets. This model estimates the allocation of new jobs in a county among the components of a county's labor force. Third, we summarize the concepts of "job chains" and "leakages" and discuss the relationship between these concepts and community-level impacts. Finally, we conclude with a discussion of how insights into labor market adjustments may be used to improve public policy in community planning and industrial development.Labor and Human Capital,