Analyzing the Reduced Required BS Density due to CoMP in Cellular Networks

In this paper we investigate the benefit of base station (BS) cooperation in the uplink of coordinated multi-point (CoMP) networks. Our figure of merit is the required BS density required to meet a chosen rate coverage. Our model assumes a 2-D network of BSs on a regular hexagonal lattice in which path loss, lognormal shadowing and Rayleigh fading affect the signal received from users. Accurate closed-form expressions are first presented for the sum-rate coverage probability and ergodic sum-rate at each point of the cooperation region. Then, for a chosen quality of user rate, the required density of BS is derived based on the minimum value of rate coverage probability in the cooperation region. The approach guarantees that the achievable rate in the entire coverage region is above a target rate with chosen probability. The formulation allows comparison between different orders of BS cooperation, quantifying the reduced required BS density from higher orders of cooperation.Comment: Accepted for presentation in IEEE Globecom Conf., to be held in Atlanta, USA, Dec. 2013. arXiv admin note: text overlap with arXiv:1302.159

Dermatomyositis revealing breast cancer: report of a case

Dermatomyositis (DM) is a rare connective corresponding to an inflammatory disease of skeletal muscles. Paraneoplastic origin must always be sought, primarily gynecological tumor in women, but the investigations are often made difficult by the fact that a primary tumor is often not detectable at the time of the cutaneous manifestations. This approach includes in addition to the monitoring report at regular intervals of 6 to 12 months for two years after diagnosis. We report a case of Dermatomyositis revealing breast cancer

Tumeurs rares de l’ovaire: à propos d’une série de 11 cas de tumeurs non épithéliales malignes de l’ovaire

Les tumeurs non épithéliales malignes de l'ovaire représentent environ 20% des cancers de l'ovaire. L'objectif de notre travail est de dresser lesparticularités diagnostiques cliniques et d'imagerie de ces tumeurs. Nous avons procédé à une étude rétrospective portant sur 11 cas de tumeursnon épithéliales de l'ovaire. Ces tumeurs ont été colligées au service de gynécologie et obstétrique I du CHU Hassan II de Fès sur une période de 4 ans, entre janvier 2009 et décembre 2012. Les tumeurs germinales représentant 54% (6 patientes) des cas alors que les tumeurs du cordonsexuel ont été représentées par 4 cas de tumeurs de granulosa de type adulte et nous avons colligés un cas de lymphome ovarien primitif. Lasymptomatologie clinique était dominée par la distension abdominale associée souvent à des douleurs abdominopelviennes chroniques. La tailletumorale moyenne était de 175 mm avec un aspect solido-kystique dans 54% des cas. Le dosage des marqueurs tumoraux (hormone chorioniquegonadotrope, lactate déshydrogénase, CA 125, alpha-foetoprotéine) a été réalisé chez toutes les patientes. La découverte d'une masse annexiellesuspecte chez une jeune femme doit, outre une tumeur frontière ou un cancer épithélial de l'ovaire, évoquer une tumeur non épithéliale, a fortiorisi cette masse est volumineuse, si elle est associée à des signes d'hyperestrogénie ou d'androgénie

Carcinome métaplasique du sein avec différenciation osseuse extensive: À propos d’un cas

Le carcinome métaplasique du sein est une entité rare et bien individualisé par l'OMS. Il représente moins de 1 % des cancers invasifs du sein et constitue un groupe tumoral hétérogène soit purement épithélial soit à doublecontingent épithélial et mésenchymateuse. Le carcinome métaplasique avec différenciation osseuse extensive est très rare. Il représente 0.2% des carcinomes du sein. Nous rapportant un cas exceptionnel d'un carcinome métaplasique du sein avec différenciation osseuse extensive chez une patiente de 53 ans. A travers ce cas et une revue de la littérature, les caractéristiques anatomo-cliniques, radiologique, thérapeutiques et évolutives seront discutées

Sheehan's Syndrome A Case Report and Literature Review

Post-partum pituitary necrosis (Sheehan's syndrome) is a rare complication of post-partum hemorrhage. The diagnosis can be erratic and often delayed. In this case report of Sheehan's syndrome in the post-partum period, the signs were characterized by agalactia, severe hypoglycemia, and low serum levels of thyroid hormones, cortico-adrenal hormones, and gonadotrophin (FSH, LH). The hypophyseal magnetic resonance imaging confirmed the diagnosis of hypopituitarism secondary to pituitary necrosis

Role of condensates in modulating DNA repair pathways and its implication for chemoresistance

For cells, it is important to repair DNA damage, such as double-strand and single-strand DNA breaks, because unrepaired DNA can compromise genetic integrity, potentially leading to cell death or cancer. Cells have multiple DNA damage repair pathways that have been the subject of detailed genetic, biochemical, and structural studies. Recently, the scientific community has started to gain evidence that the repair of DNA double-strand breaks may occur within biomolecular condensates and that condensates may also contribute to DNA damage through concentrating genotoxic agents used to treat various cancers. Here, we summarize key features of biomolecular condensates and note where they have been implicated in the repair of DNA double-strand breaks. We also describe evidence suggesting that condensates may be involved in the repair of other types of DNA damage, including single-strand DNA breaks, nucleotide modifications (e.g., mismatch and oxidized bases), and bulky lesions, among others. Finally, we discuss old and new mysteries that could now be addressed considering the properties of condensates, including chemoresistance mechanisms

Assessment of Toxicological Effect of Organophosphate, Malathion, on Matrix Metalloproteinase-1 and Matrix Metalloproteinase-2 in 3rd Instar Larvae of Drosophila melanogaster

Matrix metalloproteinase (MMP) is a type of protease that degrades and removes the extracellular matrix of the cell. Only matrix metalloproteinase-1 (MMP-1) and matrix metalloproteinase-2 (MMP-2) are found in Drosophila, playing different roles in the fruit fly. Malathion is a lethal insecticide which mostly affects the neurological system of Drosophila. Hence, the objective of the study was to evaluate the toxicological effect of the organophosphate ‒ Malathion ‒ on MMP-1 and MMP-2 in 3rd instar larvae of Drosophila melanogaster using appropriate techniques. A total of 80 third instar larvae of Drosophila melanogaster were taken for our experiment (40 larvae for MMP-1 and 40 larvae for MMP-2). For each assessment with 40 larvae, 20 larvae were treated with LC50 dose of Malathion and 20 larvae were taken as control sample. Casein and gelatin zymography were run at room temperature to detect MMP-1 and MMP-2 expression in both control and treated larvae sample. Expressions of both matrix metalloproteinases in treated larvae changed substantially. The level of MMP-1 increased from 35.38% to 64.62%. MMP-2 level also rose from 38.37% to 61.63%. Our result implies that an LC50 dose of Malathion may activate oxidative stress and upregulate MMP-1 and MMP-2 levels in 3rd instar larvae of Drosophila. The deleterious outcome of Malathion could be seen in other non-target organisms, including pollinators and humans. Hence, the use of such compounds should be checked to minimize the risk of insecticide toxicity