Metalloporphyrin intercalation in liposome membranes: ESR study

Liposomes characterized by membranes featuring diverse fluidity (liquid-crystalline and/or gel phase), prepared from egg yolk lecithin (EYL) and dipalmitoylphosphatidylcholine (DPPC), were doped with selected metalloporphyrins and the time-related structural and dynamic changes within the lipid double layer were investigated. Porphyrin complexes of Mg(II), Mn(III), Fe(III), Co(II), Ni(II), Cu(II), Zn(II), and the metal-free base were embedded into the particular liposome systems and tested for 350 h at 24°C using the electron spin resonance (ESR) spin probe technique. 5-DOXYL, 12-DOXYL, and 16-DOXYL stearic acid methyl ester spin labels were applied to explore the interior of the lipid bilayer. Only the 16-DOXYL spin probe detected evident structural changes inside the lipid system due to porphyrin intercalation. Fluidity of the lipid system and the type of the porphyrin complex introduced significantly affected the intermolecular interactions, which in certain cases may result in self-assembly of metalloporphyrin molecules within the liposome membrane, reflected in the presence of new lines in the relevant ESR spectra. The most pronounced time-related effects were demonstrated by the EYL liposomes (liquid-crystalline phase) when doped with Mg and Co porphyrins, whereas practically no spectral changes were revealed for the metal-free base and both the Ni and Zn dopants. ESR spectra of the porphyrin-doped gel phase of DPPC liposomes did not show any extra lines; however, they indicated the formation of a more rigid lipid medium. Electronic configuration of the porphyrin’s metal center appeared crucial to the degree of molecular reorganization within the phospholipid bilayer system

THE ATLAS EXPERIMENT ON-LINE MONITORING AND FILTERING AS AN EXAMPLE OF REAL-TIME APPLICATION

The ATLAS detector, recording LHC particles’ interactions, produces events with rate of40 MHz and size of 1.6 MB. The processes with new and interesting physics phenomena arevery rare, thus an efficient on-line filtering system (trigger) is necessary. The asynchronouspart of that system relays on few thousands of computing nodes running the filtering software.Applying refined filtering criteria results in increase of processing times what may lead tolack of processing resources installed on CERN site. We propose extension to this part ofthe system based on submission of the real-time filtering tasks into the Grid

Identification of the Thermal Conductivity Coefficient in the Heat Conduction Model with Fractional Derivative

Main goal of the paper is to present the algorithm serving to solve the heat conduction inverse problem. Authors consider the heat conduction equation with the Riemann-Liouville fractional derivative and with the second and third kind boundary conditions. This type of model with fractional derivative can be used for modelling the heat conduction in porous media. Authors deal with the heat conduction inverse problem, which, in this case, consists in identifying an unknown thermal conductivity coefficient. Measurements of temperature, in selected point of the region, are the input data for investigated inverse problem. Basing on this information, a functional describing the error of approximate solution is created. Minimizing of this functional is necessary to solve the inverse problem. In the presented approach the Ant Colony Optimization (ACO) algorithm is used for minimization

Performance aspects of data delivery using hierarchical storage management systems in the grid

Grid computing has recently gained in popularity. Grid applications can be very demanding of the data storage facilities in the Grid. The existing data grid services are often insufficient and additional optimization of the data access is necessary. This paper presents research concerning the optimization aspects of data management for Hierarchical Storage Management (HSM) systems in the Grid

Podstawowe własności macierzy pełnych

In this paper the, so called, full matrices are distinguished. A number of basic properties of such matrices are also presented. Moreover, few possible directions for further research are indicated.W artykule wyróżniono tzw. macierze pełne. Przedstawiono wiele podstawowych własności tych macierzy. Wskazano też kilka możliwych kierunków badań