Unusual iridoid glycosides in Veronica sects. Hebe and Labiatoides

In a chemosystematic investigation of three Southern hemisphere species of Veronica, namely the Australian V. derwentiana Andrews and V. perfoliata R.Br. (formerly Derwentia species), and the New Zealand V. catarractae G. Forster (formerly a species of Parahebe), the water-soluble constituents were isolated and identified by spectroscopic methods. Apart from other iridoid glucosides common to the genus, three unusual substituted benzoyl esters of aucubin (derwentiosides A-C) were obtained from V. derwentiana and a chlorinated iridoid glycoside (catarractoside) from V. catarractae in addition to other iridoids common to the genus. The chemical profile of V. perfoliata is similar to that of Northern hemisphere species of Veronica because of the presence of characteristic 6-O-catalpol esters. The profile of V. derwentiana is unique, since 6-O-esters of aucubin rather than of catalpol dominate, however, the acyl groups are the same as those present in catalpol esters found in some other Veronica sections. V. catarractae also contains one of the catalpol esters characteristic of Veronica, but in addition three 6-O-rhamnopyranosyl substituted iridoid glycosides, one of which is 6-O-rhamnopyranosylcatalpol. Esters of the latter compound are previously only known from the more derived species in recent phylogenetic trees of sect. Hebe to which V. catarractae now also belongs, but as a more basal member

Selvfølgelige forventninger: – Fontænehusene som psykosocial rehabiliteringsmodel

Selvfølgelige forventninger – Fontænehusene som psykosocial rehabiliteringsmodel er den afsluttende rapport fra et forskningsprojekt omkring Fontænehusene – eller klub-husene som de oftest kaldes. I Danmark er der i dag ni klubhuse geografisk fordelt i Jylland, på Sjælland og Bornholm. De udgør dagligt eller jævnligt et aktivitetstilbud for samlet op mod tre hundrede voksne psykiatribrugere og unge med psykosociale vanskeligheder.Medlemmer med et aldersspænd fra først i 20’erne til op i 60’erne og med psykiske vanskeligheder varierende fra yngre med behov for et midlertidigt sted at finde sig selv på den fortsatte vej mod uddannelse eller ordinært lønarbejde, til ældre med en lang psykiatrisk karriere bag sig og med deltagelse i klubhusets aktiviteter som en meningsfuld dagligdag, så langt øjet rækker frem.Fontænehusene i Danmark kan ses et af de mere utraditionelle bud på en psyko-social rehabiliteringsmodel, der gør sig bemærket i kraft af fokus på at skabe stabile og strukturerede rammer og sociale fællesskaber, hvor borgere med diagnosticerede sindslidelser eller massive psykiske vanskeligheder har muligheder for ’at komme sig’ ud fra empowerment inspirerede livsmestringsstrategier frem for individuelt tilrettelagte terapeutiske behandlingsforløb

A new phenylethanoid triglycoside in Veronica beccabunga L

Jensen SR, Opitz S, Gotfredsen CH. A new phenylethanoid triglycoside in Veronica beccabunga L. Biochemical Systematics and Ecology. 2011;39(3):193-197.Besides the expected iridoid glucosides aucubin and catalpol as well as three known esters of the latter, Veronica beccabunga (brooklime) was shown to contain five carboxylated iridoid glucosides, namely gardoside, mussaenosidic acid, 8-epiloganic acid, arborescosidic acid and alpinoside. In addition to these compounds, the plant contained salidroside and a previously unknown caffeoyl phenylethanoid glycoside (CPG) which we have named chionoside J. The structure was elucidated mainly by 1D and 2D NMR spectroscopy to be 2 ''-(beta-glucopyranosyl)-plantamajoside. The distribution of plantamajoside and its derivatives as well as that of carbocyclic iridoids with an 8,9-double bond is briefly discussed, and it is noted that such compounds are mainly confined to the tribe Veroniceae of the Plantaginaceae. (C) 2011 Elsevier Ltd. All rights reserved