Concentration response curve of Peakrapid cells expressing T2R38 after stimulation with increasing DMSO (EC50 = 178 mM).

<p>Results are presented as the percentage of the response elicited by 0.1 mM of phenylthiocarbamide (PTC) used as a reference agonist. Controls correspond to mock transfected cells. Results are presented as mean ± SEM of 3 independent experiments.</p

DMSO is an agonist of T2R38 which questions the agonistic effect of N-butyryl-L-homoserine lactone (C4HSL) and N-3-oxo-dodecanoyl-L-homoserine lactone (C12HSL).

<p>The response of T2R38 to a stimulation by quorum sensing lactone and to the solvent dimethylsulfoxide (DMSO) was monitored using a Ca²⁺-based functional assay. Results are presented as the percentage of the response elicited by 0.1 mM of phenylthiocarbamide (PTC) used as a reference agonist. Dimethylsulfoxide (DMSO) activated T2R38. Controls correspond to mock transfected cells. Results are presented as mean ± SEM of 3 independent experiments. The false discovery rates (fdr) are indicated above the columns, * indicate a significant result (fdr < 0.05).</p