902 research outputs found
Are Sunscreen a New Environmental Risk Associated with Coastal Tourism?
The world coastal-zone population and coastal tourism are expected to grow during this century. Associated with that, there will be an increase in the use of sunscreens and cosmetics with UV-filters in their formulation, which will make coastal regions worldwide susceptible to the impact of these cosmetics. Recent investigations indicate that organic and inorganic UV-filters, as well as many other components that are constituents of the sunscreens, reach the marine environment - directly as a consequence of water recreational activities and/or indirectly from wastewater treatment plants (WWTP) effluents. Toxicity of organic and inorganic UV filters has been demonstrated in aquatic organism. UV-filters inhibit growth in marine phytoplankton and tend to bioaccumulate in the food webs. These findings together with coastal tourism data records highlight the potential risk that the increasing use of these cosmetics would have in coastal marine areas. Nevertheless, future investigations into distribution, residence time, aging, partitioning and speciation of their main components and by-products in the water column, persistence, accumulation and toxicity in the trophic chain, are needed to understand the magnitude and real impact of these emerging pollutants in the marine system. © 2015 Elsevier Ltd.D.S.-Q. was supported by the JAE-predoc program of the Spanish National Research Council (CSIC)Peer Reviewe
Disociación escafo-semilunar asociada a fractura de escafoides carpiano: a propósito de un caso
Según el mecanismo clásico de producción de inestabilidad perilunar progresiva, la fractura de
escafoides y la disociación escafo-semilunar completa no podrían producirse de forma conjunta; sin embargo,
hay varios casos documentados. Debido a su baja frecuencia de diagnóstico, es escasa la literatura publicada al
respecto del manejo y resultados de estas lesiones de forma conjunta. Presentamos un caso de asociación de una
fractura de escafoides y disociación escafo-semilunar tratado mediante osteosíntesis percutánea, artroscopia y
reanclaje abierto ligamentoso, con buenos resultados. Describimos su evolución clínica y radiológica, así como
una revisión de la bibliografíaAccording to the generally accepted pathomechanisms of carpal instability, a scaphoid fracture
and a scapholunate dissociation should not occur together. Several cases are published in the literature even there
is no much written about this topic, its treatment and outcome. These concurrent injuries are herefore likely underdiagnosed.
We present a case with scaphoid fracture and a scapholunate dissociation in association, successfully.
We describe the clinical, radiological outcome as well as the important literature about this topi
Identification of differential proteins in liver cells upon depletion of prohibitin
Comunicaciones a congreso
Adaptation and validation of the Yildirim & Correia nomophobia scale in Spanish students of ‘Compulsory Secondary Education’
Aunque no se trata de un fenómeno reciente, la Nomofobia (No Mobile Phone Phobia) entendida como una adicción comportamental que implica un alto temor a quedarse sin teléfono móvil, está siendo objeto de investigación desde diferentes disciplinas dada las importantes consecuencias que se están observando entre la población más joven. Sin embargo, son pocos los instrumentos capaces de medir esta adicción no reconocida como tal por el DSM-V. En el presente trabajo se ha llevado a cabo el proceso de adaptación y validación de la escala de medición de la Nomofobia de Yildirim y Correia. Para ello se procedió a una adaptación lingüística y cultural de la misma, seguida de una revisión por parte de expertos en la materia. La decisión del grupo de expertos supuso una modificación de la redacción y la inclusión de un nuevo ítem. La escala resultante se aplicó a una muestra de 372 estudiantes de Educación Secundaria Obligatoria, en institutos públicos de la provincia de Alicante. Los resultados permitieron la validación de la escala objeto de este estudio.Although is not a recent phenomenon, Nomophobia (No Mobile Phone Phobia), understood as a behavioral addiction that implies a high fear of being left without a mobile phone, is being researched from different disciplines given the important consequences that are being observed between the younger population. However, there are few instruments to measure this addiction not recognized by the DSM-V. In the present work the process of adaptation and validation of the measurement scale of the Nomophobia of Yildirim and Correia has been carried out. A linguistic and cultural adaptation of the scale was carried out, followed by a review by the experts in the field. The group of experts proposed a modification of the wording and the inclusion of a new item. The final scale was applied to a sample of 372 students of Compulsory Secondary Education, in public institutes of the Province of Alicante. The results allowed the validation of the Yildirim and Correia scale
Data on interleukin (IL)-2- and IL-15-dependent changes in IL-2Rβ and IL-2Rγ complexes
We provide detailed datasets from our analysis of the proteins that associate with IL-2Rbeta and IL-2Rgamma in T-cells stimulated with IL-2 or IL-15 compared with resting T-cells, as identified by SILAC-based quantitative proteomics. We also include quantitative data regarding site-specific phosphorylation events observed both in IL-2Rbeta and IL-2Rgamma. Moreover, we provide results demonstrating the specific protein recruitment capacity of four of those site-specific phosphorylations. The proteomics and phosphoproteomics data described in this article is associated with a research article entitled "Characterization of receptor-associated protein complex assembly in Interleukin (IL)-2- and IL-15-activated T-lymphocytes" (Osinalde et al., 2016 [1]). The mass spectrometry data have been deposited to the ProteomeEXchange Constorium with the identifier PXD002386
Molecular implications of prohibitin-1 deficiency in liver homeostasis
Comunicaciones a congreso
Contribution of MS-Based Proteomics to the Understanding of Herpes Simplex Virus Type 1 Interaction with Host Cells
Like other DNA viruses, herpes simplex virus type 1 (HSV-1) replicates and proliferates in host cells continuously modulating the host molecular environment. Following a sophisticated temporal expression pattern, HSV-1 encodes at least 89 multifunctional proteins that interplay with and modify the host cell proteome. During the last decade, advances in mass spectrometry applications coupled to the development of proteomic separation methods have allowed to partially monitor the impact of HSV-1 infection in human cells. In this review, we discuss the current use of different proteome fractionation strategies to define HSV-1 targets in two major application areas: (i) viral-protein interactomics to decipher viral-protein interactions in host cells and (ii) differential quantitative proteomics to analyze the virally induced changes in the cellular proteome. Moreover, we will also discuss the potential application of high-throughput proteomic approaches to study global proteome dynamics and also post-translational modifications in HSV-1-infected cells that will greatly improve our molecular knowledge of HSV-1 infection
Interactions Between Blackcurrant Polyphenols and Food Macronutrients in Model Systems: In Vitro Digestion Studies
[EN] Blackcurrant pomace, rich in fiber and polyphenols, can be used as added-value ingredientfor food formulation. However, the bounding of polyphenols to pomace and the interactions thattake place with food nutrients modify polyphenol bioaccessibility. This work studied the interactionsbetween polyphenols and the main macronutrients in foods, and the changes that occurred duringin vitrodigestion, using model systems. Model systems were formulated with (i) water, (ii) wheatstarch, (iii) olive oil, (iv) whey protein, and (v) a model combining all the ingredients. Polyphenolswere added from two sources: as pomace and as a polyphenolic pomace extract. Interactions betweenpolyphenols and macronutrients were studied using light microscopy; total phenolic content (TPC)and antioxidant capacity (AC) were determined before and after thein vitrodigestion process.Lastly, the bioaccessibility of the samples was calculated. Polyphenols incorporated into the modelsystems as pomace increased their bioaccessibility if compared to polyphenols added as extract.For single-nutrient model systems formulated with pomace, the bioaccessibility was higher thanwhen the system contained all the nutrients. Of all the components studied, the greatest effect onbioaccessibility was observed for proteins.This research was funded by Instituto Nacional de Investigación y Tecnología Agraria y
Alimentaria (INIA-Spain) through the BERRYPOM. Adding value to processing waste: innovative
ways to incorporate fibers from berry pomace in baked and extruded cereal-based foods project
included in the ERA-NET-SUSFOOD program.Diez-Sánchez, E.; Quiles Chuliá, MD.; Hernando Hernando, MI. (2021). Interactions Between Blackcurrant Polyphenols and Food Macronutrients in Model Systems: In Vitro Digestion Studies. Foods. 10(4):1-14. https://doi.org/10.3390/foods10040847S11410
Distribution and transport of dissolved trace metals in the Gulf of Cádiz, Spain
Trabajo presentado en el XVIII Seminario Ibérico de Química Marina, celebrado en Alicante (España) de 20 al 22 de julio de 2016.The Gulf of Cadiz plays a key role in the exchange of biogeochemical fluxes between the Mediterranean Sea and the Atlantic Ocean through the Strait of Gibraltar. Oceanographers have carried out many investigations in the Gulf of Cádiz on water mass circulation and mass balance of nutrients and carbon. However, despite its importance in the global ocean functioning, studies on trace metals in the Gulf of Cádiz and Strait of Gibraltar waters are very scarce. Here we show the concentrations of dissolved trace metal composition (i.e. Ag, Cd, Co, Cu, Fe, Mo, Ni, Pb and Zn) in the Gulf of Cádiz and Mediterranean Sea surface waters as obtained from 5 oceanographic campaigns. Our results indicate that the Gulf of Cádiz surface water mass is receiving large amounts of trace metals transported by the different rivers that flow into the Gulf of Cádiz. Thus, dissolved trace metals in these waters were highly variable with the highest ranges measured for Co (0.06 – 3.1 nM), Fe (0.6 – 392 nM) and Pb (0.04 – 512 nM).This work was financed by the MICCIN grants MEGOCA (CTM2014-59244-C3-3-R).N
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