Retos de ser mujer trans en Colombia: aspectos asociados a sus condiciones de vida

Colombia es un país cisnormativo en el cual durante los últimos años ha cobrado relevancia las discusiones y acciones en pro del bienestar y la salud de las mujeres trans. De esta manera, en el presente artículo presentamos los retos de las mujeres trans asociados a sus condiciones de vida a partir de una revisión bibliográfica en Colombia de la literatura publicada entre 2010 y 2020. Los hallazgos dan cuenta de escasos estudios sobre las mujeres trans, así como las cualidades y procesos cotidianos de reproducción social que interfieren en el goce y protección de sus derechos asociados a las situaciones de estigma, discriminación y violencias que enfrentan por su identidad de género no hegemónica. Esto impacta negativamente en sus condiciones de vida, su salud y bienestar, y perpetúa las inequidades e injusticias que tienen que enfrentar y han enfrentado de manera estructural e histórica

A qué sabe el norte?

Libro que compila saberes de las recetas ancestrales y sabores tradicionales de la gastronomía Nortesantandereana, recopila 3 rutas de turismo gastronómico que conjuga 30 municipios de norte de santander y más de 300 tipos de sopas, platos fuertes y postres.Book that compiles knowledge of ancestral recipes and traditional flavors of gastronomy Nortesantandereana, compiles 3 routes of gastronomic tourism that brings together 30 municipalities of northern Santander and more than 300 types of soups, main dishes and desserts.Ruta del durazno y el agua -- Ruta del oro negro -- Ruta del río y la gran convención -- Las mujeres de la independencia -- Honrando a nuestros portadores del saber -- A qué sabe el norte-recetarioPrimera ediciónna230 página

Medio ambiente, sociedad, ética, auditoría y educación: reflexiones desde la disciplina contable.

Los servicios y desarrollos tecnológicos en todos los sectores económicos, al igual que la actualidad social, educativa, ambiental y agropecuaria en el mundo, constituyen oportunidades para que los contadores públicos se alejen de los procesos netamente manuales, y se acerquen al desarrollo de actividades que agreguen mayor valor a las unidades económicas en las cuales se desempeñan profesionalmente; en consecuencia, la academia recibe en la misma dimensión retos importantes que conllevan revisar y actualizar constantemente los contenidos, medios y escenarios educativos, a través de los cuales se cumple con la misión de formar contadores públicos idóneos para la sociedad. El programa de Contaduría Pública de la Corporación Universitaria Minuto de Dios – UNIMINUTO, UVD, consiente de la responsabilidad que tiene al ser uno de los programas con mayor número de estudiantes actualmente en Colombia, ha cimentado a lo largo de sus primeros ocho años bases adecuadas y orientadas a constituir una comunidad académica reconocida por sus aportes alternativos a la profesión y a la industria contable en general. El libro Medio ambiente, sociedad, ética, auditoría y educación en su segunda versión es una muestra de cómo el III Encuentro Nacional y II Internacional de Investigación Contable UNIMINUTO UVD, llevado a cabo en Bogotá en Octubre del 2018, se convirtió en un espacio extraordinario en el que se reunieron representantes de los veintiún lugares de oferta del programa de Contaduría Pública UNIMINUTO UVD, para compartir los avances de los proyectos que se tejen diariamente en diferentes lugares del territorio nacional, y que hacen parte integral de las cuatro sublíneas de investigación que se desarrollan al interior del programa y que se visualizan claramente lo largo del presente libro

Medio ambiente, sociedad, ética, auditoría y educación: reflexiones desde la disciplina contable.

Los servicios y desarrollos tecnológicos en todos los sectores económicos, al igual que la actualidad social, educativa, ambiental y agropecuaria en el mundo, constituyen oportunidades para que los contadores públicos se alejen de los procesos netamente manuales, y se acerquen al desarrollo de actividades que agreguen mayor valor a las unidades económicas en las cuales se desempeñan profesionalmente; en consecuencia, la academia recibe en la misma dimensión retos importantes que conllevan revisar y actualizar constantemente los contenidos, medios y escenarios educativos, a través de los cuales se cumple con la misión de formar contadores públicos idóneos para la sociedad. El programa de Contaduría Pública de la Corporación Universitaria Minuto de Dios – UNIMINUTO, UVD, consiente de la responsabilidad que tiene al ser uno de los programas con mayor número de estudiantes actualmente en Colombia, ha cimentado a lo largo de sus primeros ocho años bases adecuadas y orientadas a constituir una comunidad académica reconocida por sus aportes alternativos a la profesión y a la industria contable en general. El libro Medio ambiente, sociedad, ética, auditoría y educación en su segunda versión es una muestra de cómo el III Encuentro Nacional y II Internacional de Investigación Contable UNIMINUTO UVD, llevado a cabo en Bogotá en Octubre del 2018, se convirtió en un espacio extraordinario en el que se reunieron representantes de los veintiún lugares de oferta del programa de Contaduría Pública UNIMINUTO UVD, para compartir los avances de los proyectos que se tejen diariamente en diferentes lugares del territorio nacional, y que hacen parte integral de las cuatro sublíneas de investigación que se desarrollan al interior del programa y que se visualizan claramente lo largo del presente libro

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Minimal information for studies of extracellular vesicles 2018 (MISEV2018):a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles (“MISEV”) guidelines for the field in 2014. We now update these “MISEV2014” guidelines based on evolution of the collective knowledge in the last four years. An important point to consider is that ascribing a specific function to EVs in general, or to subtypes of EVs, requires reporting of specific information beyond mere description of function in a crude, potentially contaminated, and heterogeneous preparation. For example, claims that exosomes are endowed with exquisite and specific activities remain difficult to support experimentally, given our still limited knowledge of their specific molecular machineries of biogenesis and release, as compared with other biophysically similar EVs. The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities. Finally, a checklist is provided with summaries of key points

Repositioning of the global epicentre of non-optimal cholesterol

High blood cholesterol is typically considered a feature of wealthy western countries(1,2). However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world(3) and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which have different effects on human health(4,5). However, the trends of HDL and non-HDL cholesterol levels over time have not been previously reported in a global analysis. Here we pooled 1,127 population-based studies that measured blood lipids in 102.6 million individuals aged 18 years and older to estimate trends from 1980 to 2018 in mean total, non-HDL and HDL cholesterol levels for 200 countries. Globally, there was little change in total or non-HDL cholesterol from 1980 to 2018. This was a net effect of increases in low- and middle-income countries, especially in east and southeast Asia, and decreases in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe. As a result, countries with the highest level of non-HDL cholesterol-which is a marker of cardiovascular riskchanged from those in western Europe such as Belgium, Finland, Greenland, Iceland, Norway, Sweden, Switzerland and Malta in 1980 to those in Asia and the Pacific, such as Tokelau, Malaysia, The Philippines and Thailand. In 2017, high non-HDL cholesterol was responsible for an estimated 3.9 million (95% credible interval 3.7 million-4.2 million) worldwide deaths, half of which occurred in east, southeast and south Asia. The global repositioning of lipid-related risk, with non-optimal cholesterol shifting from a distinct feature of high-income countries in northwestern Europe, north America and Australasia to one that affects countries in east and southeast Asia and Oceania should motivate the use of population-based policies and personal interventions to improve nutrition and enhance access to treatment throughout the world.Peer reviewe

Contributions of mean and shape of blood pressure distribution to worldwide trends and variations in raised blood pressure: A pooled analysis of 1018 population-based measurement studies with 88.6 million participants

© The Author(s) 2018. Background: Change in the prevalence of raised blood pressure could be due to both shifts in the entire distribution of blood pressure (representing the combined effects of public health interventions and secular trends) and changes in its high-blood-pressure tail (representing successful clinical interventions to control blood pressure in the hypertensive population). Our aim was to quantify the contributions of these two phenomena to the worldwide trends in the prevalence of raised blood pressure. Methods: We pooled 1018 population-based studies with blood pressure measurements on 88.6 million participants from 1985 to 2016. We first calculated mean systolic blood pressure (SBP), mean diastolic blood pressure (DBP) and prevalence of raised blood pressure by sex and 10-year age group from 20-29 years to 70-79 years in each study, taking into account complex survey design and survey sample weights, where relevant. We used a linear mixed effect model to quantify the association between (probittransformed) prevalence of raised blood pressure and age-group- and sex-specific mean blood pressure. We calculated the contributions of change in mean SBP and DBP, and of change in the prevalence-mean association, to the change in prevalence of raised blood pressure. Results: In 2005-16, at the same level of population mean SBP and DBP, men and women in South Asia and in Central Asia, the Middle East and North Africa would have the highest prevalence of raised blood pressure, and men and women in the highincome Asia Pacific and high-income Western regions would have the lowest. In most region-sex-age groups where the prevalence of raised blood pressure declined, one half or more of the decline was due to the decline in mean blood pressure. Where prevalence of raised blood pressure has increased, the change was entirely driven by increasing mean blood pressure, offset partly by the change in the prevalence-mean association. Conclusions: Change in mean blood pressure is the main driver of the worldwide change in the prevalence of raised blood pressure, but change in the high-blood-pressure tail of the distribution has also contributed to the change in prevalence, especially in older age groups

Anales del III Congreso Internacional de Vivienda y Ciudad "Debate en torno a la nueva agenda urbana"

Acta de congresoEl III Congreso Internacional de Vivienda y Ciudad “Debates en torno a la NUEVa Agenda Urbana”, ha sido una apuesta de alto compromiso por acercar los debates centrales y urgentes que tensionan el pleno ejercicio del derecho a la ciudad. Para ello las instituciones organizadoras (INVIHAB –Instituto de Investigación de Vivienda y Hábitat y MGyDH-Maestría en Gestión y Desarrollo Habitacional-1), hemos convidado un espacio que se concretó con potencia en un debate transdisciplinario. Convocó a intelectuales de prestigio internacional, investigadores, académicos y gestores estatales, y en una metodología de innovación articuló las voces académicas con las de las organizaciones sociales y/o barriales en el Foro de las Organizaciones Sociales que tuvo su espacio propio para dar voz a quienes están trabajando en los desafíos para garantizar los derechos a la vivienda y los bienes urbanos en nuestras ciudades del Siglo XXI