Geographic body size variation in ectotherms: effects of seasonality on an anuran from the southern temperate forest

Indexación: Web of Science; Scopus.Background: Body size variation has played a central role in biogeographical research, however, most studies have aimed to describe trends rather than search for underlying mechanisms. In order to provide a more comprehensive understanding of the causes of intra-specific body size variation in ectotherms, we evaluated eight hypotheses proposed in the literature to account for geographical body size variation using the Darwin's frog (Rhinoderma darwinii), an anuran species widely distributed in the temperate forests of South America. Each of the evaluated hypotheses predicted a specific relationship between body size and environmental variables. The level of support for each of these hypotheses was assessed using an information-theoretic approach and based on data from 1015 adult frogs obtained from 14 sites across the entire distributional range of the species. Results: There was strong evidence favouring a single model comprising temperature seasonality as the predictor variable. Larger body sizes were found in areas of greater seasonality, giving support to the "starvation resistance" hypothesis. Considering the known role of temperature on ectothermic metabolism, however, we formulated a new, non-exclusive hypothesis, termed "hibernation hypothesis": greater seasonality is expected to drive larger body size, since metabolic rate is reduced further and longer during colder, longer winters, leading to decreased energy depletion during hibernation, improved survival and increased longevity (and hence growth). Supporting this, a higher post-hibernation body condition in animals from areas of greater seasonality was found. Conclusions: Despite largely recognized effects of temperature on metabolic rate in ectotherms, its importance in determining body size in a gradient of seasonality has been largely overlooked so far. Based on our results, we present and discuss an alternative mechanism, the "hibernation hypothesis", underlying geographical body size variation, which can be helpful to improve our understanding of biogeographical patterns in ectotherms.https://frontiersinzoology.biomedcentral.com/articles/10.1186/s12983-015-0132-

Imperfect Imitation Can Enhance Cooperation

The promotion of cooperation on spatial lattices is an important issue in evolutionary game theory. This effect clearly depends on the update rule: it diminishes with stochastic imitative rules whereas it increases with unconditional imitation. To study the transition between both regimes, we propose a new evolutionary rule, which stochastically combines unconditional imitation with another imitative rule. We find that, surprinsingly, in many social dilemmas this rule yields higher cooperative levels than any of the two original ones. This nontrivial effect occurs because the basic rules induce a separation of timescales in the microscopic processes at cluster interfaces. The result is robust in the space of 2x2 symmetric games, on regular lattices and on scale-free networks.Comment: 4 pages, 4 figure

On the discrete Peyrard-Bishop model of DNA: stationary solutions and stability

As a first step in the search of an analytical study of mechanical denaturation of DNA in terms of the sequence, we study stable, stationary solutions in the discrete, finite and homogeneous Peyrard-Bishop DNA model. We find and classify all the stationary solutions of the model, as well as analytic approximations of them, both in the continuum and in the discrete limits. Our results explain the structure of the solutions reported by Theodorakopoulos {\em et al.} [Phys. Rev. Lett. {\bf 93}, 258101 (2004)] and provide a way to proceed to the analysis of the generalized version of the model incorporating the genetic information.Comment: 15 pages, 12 figure

Conservation laws in Skyrme-type models

The zero curvature representation of Zakharov and Shabat has been generalized recently to higher dimensions and has been used to construct non-linear field theories which either are integrable or contain integrable submodels. The Skyrme model, for instance, contains an integrable subsector with infinitely many conserved currents, and the simplest Skyrmion with baryon number one belongs to this subsector. Here we use a related method, based on the geometry of target space, to construct a whole class of theories which are either integrable or contain integrable subsectors (where integrability means the existence of infinitely many conservation laws). These models have three-dimensional target space, like the Skyrme model, and their infinitely many conserved currents turn out to be Noether currents of the volume-preserving diffeomorphisms on target space. Specifically for the Skyrme model, we find both a weak and a strong integrability condition, where the conserved currents form a subset of the algebra of volume-preserving diffeomorphisms in both cases, but this subset is a subalgebra only for the weak integrable submodel.Comment: Latex file, 22 pages. Two (insignificant) errors in Eqs. 104-106 correcte

Na/K pump regulation of cardiac repolarization: Insights from a systems biology approach

The sodium-potassium pump is widely recognized as the principal mechanism for active ion transport across the cellular membrane of cardiac tissue, being responsible for the creation and maintenance of the transarcolemmal sodium and potassium gradients, crucial for cardiac cell electrophysiology. Importantly, sodium-potassium pump activity is impaired in a number of major diseased conditions, including ischemia and heart failure. However, its subtle ways of action on cardiac electrophysiology, both directly through its electrogenic nature and indirectly via the regulation of cell homeostasis, make it hard to predict the electrophysiological consequences of reduced sodium-potassium pump activity in cardiac repolarization. In this review, we discuss how recent studies adopting the Systems Biology approach, through the integration of experimental and modeling methodologies, have identified the sodium-potassium pump as one of the most\ud important ionic mechanisms in regulating key properties of cardiac repolarization and its rate-dependence, from subcellular to whole organ levels. These include the role of the pump in the biphasic modulation of cellular repolarization and refractoriness, the rate control of intracellular sodium and calcium dynamics and therefore of the adaptation of repolarization to changes in heart rate, as well as its importance in regulating pro-arrhythmic substrates through modulation of dispersion of repolarization and restitution. Theoretical findings are consistent across a variety of cell types and species including human, and widely in agreement with experimental findings. The novel insights and hypotheses on the role of the pump in cardiac electrophysiology obtained through this integrative approach could eventually lead to novel therapeutic and diagnostic strategies

Estabilidad postural estática: análisis en tiempo y frecuencia a través del desarrollo de una herramienta de software

Posture allows a subject to perform in the environment where they develop in order to act, maintaining an erect position where, using their muscles, they oppose external forces such as gravity. Certain characteristics of a posture indicate the presence of some disorder in a subject, hence the interest in its study. The analysis of postural control in relation to the stability in the standing posture is carried out using balance studies, such as stabilometry; This instrumental evaluation makes it possible to objectively assess postural balance through the study of the center of pressure (CoP) in both the time and frequency domain. There is software, usually accompanied by hardware, that calculates CoP parameters, but provides temporal or frequency data, and they are also expensive. The objective of this article is to show the development of a software tool that calculates the relevant parameters for the study of stability, carried out in a free programming language (Python), easy to use, highly useful, free, and will be delivered to personnel in the field doctor for your employment.La postura permite a un sujeto desempeñarse en el medio donde se desenvuelve manteniendo una posición erecta donde, haciendo uso de la musculatura, se opone a fuerzas exteriores como la gravedad. Características determinadas de una postura indican la presencia de algún desorden en un sujeto, de allí el interés en su estudio. El análisis del control postural en relación con la estabilidad en postura de bipedestación se realiza empleando estudios de equilibrio, tal como la estabilometría; esta evaluación instrumental permite valorar objetivamente el equilibrio postural a través del estudio del centro de presión (CoP) tanto en el dominio del tiempo como de la frecuencia. Existe software, por lo general acompañados de hardware, que calculan parámetros del CoP, pero entregan datos temporales o frecuenciales, además son costosos. El objetivo de este artículo es mostrar el desarrollo de una herramienta de software que calcula los parámetros relevantes para el estudio de la estabilidad, realizada en un lenguaje de programación libre (Python), de fácil uso, gran utilidad, gratis y será entregada a personal del ámbito médico para su empleo