COVID-19 outbreaks in a transmission control scenario: challenges posed by social and leisure activities, and for workers in vulnerable conditions, Spain, early summer 2020

Severe acute respiratory syndrome coronavirus 2 community-wide transmission declined in Spain by early May 2020, being replaced by outbreaks and sporadic cases. From mid-June to 2 August, excluding single household outbreaks, 673 outbreaks were notified nationally, 551 active (>6,200 cases) at the time. More than half of these outbreaks and cases coincided with: (i) social (family/friends’ gatherings or leisure venues) and (ii) occupational (mainly involving workers in vulnerable conditions) settings. Control measures were accordingly applied

Fotografía de la clase de séptimo curso de bachillerato de Carmen Martín Gaite en el Instituto Femenino Nacional de Enseñanza Media "Lucía de Medrano" de Salamanca.

José Martín, el padre de Carmen y Ana, siempre tuvo la intención de enviar a sus hijas a estudiar el bachillerato a Madrid al Instituto Escuela, pero el estallido de la Guerra Civil frustró sus planes y Carmen tuvo que estudiar en el Instituto Femenino Nacional de Enseñanza Media "Lucía de Medrano" de Salamanca, donde tendrá la suerte de estudiar literatura con los profesores Rafael Lapesa y Salvador Fernández Ramírez, futuros académicos de la Lengua y posibles impulsores de su futura profesión.Sumario: En el vuelto de la misma aparece en letra manuscrita: "Febrero 1943, 7ºCurso. Atención al "bulto vestido de negro capuz". De izquierda a derecha: 1ªfila: María Josefa Sánchez, Carmen Pelayo, Tere Gil, Isidora Borrego, Irene segura, Antonia Pelayo, Josefa Acosta. 2ªfila: Angelines Corrales, Yoli Bermejo, Ego, Carmen Portilla, Regina Blanco, Damiana Acosta, Carmen Fernández Viaña, Natalia Velázquez. 3ªfila: Teresa Sánchez Rodero, Visi Domínguez, Manolita Sánchez Bellido, Pilar Manjon, María Esteban. La cara del profesor está pintada.Metodología: Esta fotografía pertenece al Sobre número 2 de Carmen Martín Gaite. Hay una copia en ACMG,90,53. Hay un cambio con la otra copia en el nombre de una niña, en esta fotografía pone Luisa en el otro pone María Esteban Rodrigo

Fotografía de la clase de sexto curso de bachillerato de Carmen Martín Gaite en el Instituto Femenino Nacional de Enseñanza Media "Lucía de Medrano" de Salamanca.

José Martín, el padre de Carmen y Ana, siempre tuvo la intención de enviar a sus hijas a estudiar el bachillerato a Madrid al Instituto Escuela, pero el estallido de la Guerra Civil frustró sus planes y Carmen tuvo que estudiar en el Instituto Femenino Nacional de Enseñanza Media "Lucía de Medrano" de Salamanca, donde tendrá la suerte de estudiar literatura con los profesores Rafael Lapesa y Salvador Fernández Ramírez, futuros académicos de la Lengua y posibles impulsores de su futura profesión.Sumario: En el vuelto de la misma aparece en letra manuscrita: "6ºCurso- octubre 1941. De izquierda de derecha: Fila superior: Visi Domínguez, Angelines Corrales, Gloria Santos, Isabelita Rodrigo Larruscain, Rosa Martín, Fabiana Pascual, Manolita Sánchez Bellido, Isidora Borrego, Teresa Gil, Damiana Acosta, Cándida Guerra, Irene Segura. Fila del medio (arrodilladas): Carmen Pelayo, Sagrario Iglesias, Elida Salvador, Pilar Ramírez, Inés Morales, Josefa Acosta, María Esteban Rodrigo. Fila inferior: Sofía Bermejo, ¡¡menda!!, María Sánchez, María Gómez, Carmen Portilla, Teresa Sánchez Rodero, Mary Martin (alias rubia -pelos), Regina Blanco, Antolina Nieto Rosingana.Metodología: Esta fotografía pertenece al Álbum número 4 de Carmen Martín Gaite. Hay una copia en ACMG,90,5

Informe-memoria de la I.A.U. en el S.G. SS- 1 (Parque de Miraflores y Centro de Congresos de Córdoba). Segunda Fase

In this paper are exposed the results obtained from the archeological works carried out on the area of Miraflores' Park and Córdoba Congress Center of (2001-2003). Amoung all the archeological items found, structures from the emirate age identified as being part of the Saqunda suburb are remarkable. This work is focused on their description and analysis.En este trabajo presentamos los resultados obtenidos en la I.A.U. realizada en el Parque de Miraflores y en el Centro de Congresos de Córdoba (2001-2003). Entre los restos arqueológicos documentados destacan las estructuras de época emiral identificadas como parte del denominado arrabal de Saqunda, en cuya descripción y análisis nos centraremos

Specific Cellular and Humoral Response after the Third Dose of Anti-SARS-CoV-2 RNA Vaccine in Patients with Immune-Mediated Rheumatic Diseases on Immunosuppressive Therapy

Objective: Data on cellular and humoral immunogenicity after the third dose of anti-SARS-CoV-2 vaccines in patients with immune-mediated rheumatic diseases (IMRDs) are scarce. Herein, we evaluated the adaptive immune response in IMRD patients treated with different immunosuppressive therapies (conventional synthetic disease-modifying antirheumatic drugs [csDMARDs], biological disease-modifying antirheumatic drugs [bDMARDs], and targeted synthetic disease-modifying antirheumatic drugs [tsDMARDs]) after the booster of the anti-SARS-CoV-2 vaccine to determine whether any drug reduced the vaccine’s response. Methods: A single-center prospective study was conducted, including patients presenting with IMRD and healthy controls (HC). Specific anti-SARS-CoV-2 interferon-gamma (IFN-γ) production was evaluated between 8–12 weeks after the third dose of the SARS-CoV-2 vaccine. In addition, anti-Spike IgG antibody titers were also measured. Results: Samples were obtained from 79 IMRD patients (51 women, 28 men; mean age 57 ± 11.3 years old): 43 rheumatoid arthritis, 10 psoriatic arthritis, 14 ankylosing spondylitis, 10 undifferentiated spondyloarthritis, and 2 inflammatory bowel disease-associated spondyloarthritis (IBD-SpA). In total, 31 HC (mean age 50.9 ± 13.1 years old, 67.7% women) were included in the study. Post-vaccine results displayed positive T-cell immune responses in 68 out of 79 (86.1%) IMRD patients (82.3% of those without prior COVID-19). All HC and IMRDs patients had an antibody response against the SARS-CoV-2 receptor-binding domain; however, the HC response was significantly higher (median of 18,048 AU/mL) than in IMRDs patients (median of 6590.3 AU/mL, p < 0.001). MTX and leflunomide were associated with lower titers of IgG and IFN-γ responses. Among bDMARDs, adalimumab, etanercept, and guselkumab are associated with reduced cellular responses. Conclusion: Our preliminary data show that the majority of our IMRD patients develop cellular and humoral responses after the SARS-CoV-2 booster vaccination, emphasizing the relevance of vaccination in this group. However, the magnitude of specific responses was dependent on the immunosuppressive therapy administered. Specific vaccination protocols and personalized decisions about boosters are essential for these patients

The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies

International audienceSignificance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general population, we found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women. Autoantibodies against type I IFNs are strong and common predictors of life-threatening COVID-19. Testing for these autoantibodies should be considered in the general population

The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies

International audienceSignificance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general population, we found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women. Autoantibodies against type I IFNs are strong and common predictors of life-threatening COVID-19. Testing for these autoantibodies should be considered in the general population