The complex structure of HH 110 as revealed from Integral Field Spectroscopy

HH 110 is a rather peculiar Herbig-Haro object in Orion that originates due to the deflection of another jet (HH 270) by a dense molecular clump, instead of being directly ejected from a young stellar object. Here we present new results on the kinematics and physical conditions of HH 110 based on Integral Field Spectroscopy. The 3D spectral data cover the whole outflow extent (~4.5 arcmin, ~0.6 pc at a distance of 460 pc) in the spectral range 6500-7000 \AA. We built emission-line intensity maps of H$\alpha$, [NII] and [SII] and of their radial velocity channels. Furthermore, we analysed the spatial distribution of the excitation and electron density from [NII]/H$\alpha$, [SII]/H$\alpha$, and [SII] 6716/6731 integrated line-ratio maps, as well as their behaviour as a function of velocity, from line-ratio channel maps. Our results fully reproduce the morphology and kinematics obtained from previous imaging and long-slit data. In addition, the IFS data revealed, for the first time, the complex spatial distribution of the physical conditions (excitation and density) in the whole jet, and their behaviour as a function of the kinematics. The results here derived give further support to the more recent model simulations that involve deflection of a pulsed jet propagating in an inhomogeneous ambient medium. The IFS data give richer information than that provided by current model simulations or laboratory jet experiments. Hence, they could provide valuable clues to constrain the space parameters in future theoretical works.Comment: 12 pages, 15 figures Accepted in MNRA

Shock excitation of the knots of Hen 3-1475

We present new optical STIS HST spectroscopic observations of the jets of the proto-planetary nebula Hen 3-1475. The excitation conditions of the knots of Hen 3-1475 are derived from the observed optical spectra, confirming that the knots are shock excited. The shocked spectra are qualitatively reproduced by simple ``3/2''D bow shock models. We present a set of bow shock models devoted to planetary nebulae, and discuss the effects of the pre-ionization conditions, the bow shock velocity, the bow shock shape and the chemical abundances on the predicted spectra. To explore the reliability of the ``3/2''D bow shock models, we also compare the observed spectra of other three proto-planetary nebulae (M 1-92, M 2-56 and CRL 618) to the predicted spectra.Comment: 13 pages. A&A (in press

Time-dependent ejection velocity model for the outflow of Hen 3--1475

We present 2D axisymmetric and 3D numerical simulations of the proto-planetary nebula Hen 3-1475, which is characterized by a remarkably highly collimated optical jet, formed by a string of shock-excited knots along the axis of the nebula. It has recently been suggested that the kinematical and morphological properties of the Hen 3-1475 jet could be the result of an ejection variability of the central source (Riera et al. 2003). The observations suggest a periodic variability of the ejection velocity superimposed on a smoothly increasing ejection velocity ramp. From our numerical simulations, we have obtained intensity maps (for different optical emission lines) and position-velocity diagrams, in order to make a direct comparison with the HST observations of this object. Our numerical study allows us to conclude that a model of a precessing jet with a time-dependent ejection velocity, which is propagating into an ISM previously perturbed by an AGB wind, can succesfully explain both the morphological and the kinematical characteristics of this proto-planetary nebula.Comment: Astronomy and Astrophysics (accepted) (8 figures

Integral Field Spectroscopy of HH 262: The Spectral Atlas

HH 262 is a group of emitting knots displaying an "hour-glass" morphology in the Halpha and [SII] lines, located 3.5' to the northeast of the young stellar object L1551-IRS5, in Taurus. We present new results of the kinematics and physical conditions of HH 262 based on Integral Field Spectroscopy covering a field of 1.5'x3', which includes all the bright knots in HH 262. These data show complex kinematics and significant variations in physical conditions over the mapped region of HH 262 on a spatial scale of <3". A new result derived from the IFS data is the weakness of the [NII] emission (below detection limit in most of the mapped region of HH 262), including the brightest central knots. Our data reinforce the association of HH 262 with the redshifted lobe of the evolved molecular outflow L1551-IRS5. The interaction of this outflow with a younger one, powered by L1551 NE, around the position of HH 262 could give rise to the complex morphology and kinematics of HH 262.Comment: Accepted for publication in MNRA

Integral field spectroscopy of M1-67. A Wolf-Rayet nebula with LBVN appearance

This work aims to disentangle the morphological, kinematic, and chemical components of the nebula M1-67 to shed light on its process of formation around the central Wolf-Rayet (WR) star WR124. We have carried out integral field spectroscopy observations over two regions of M1-67, covering most of the nebula in the optical range. Maps of electron density, line ratios, and radial velocity were created to perform a detailed analysis of the two-dimensional structure. We studied the physical and chemical properties by means of integrated spectra selected over the whole nebula. Photoionization models were performed to confirm the empirical chemical results theoretically. In addition, we analysed infrared spectroscopic data and the MIPS 24micron image of M1-67 from Spitzer. We find that the ionized gas of M1-67 is condensed in knots aligned in a preferred axis along the NE-SW direction, like a bipolar structure. Both electron density and radial velocity decrease in this direction when moving away from the central star. From the derived electron temperature, Te~8200 K, we have estimated chemical abundances, obtaining that nitrogen appears strongly enriched and oxygen depleted. From the last two results, we infer that this bipolarity is the consequence of an ejection of an evolved stage of WR124 with material processed in the CNO cycle. The infrared study has revealed that the bipolar axis is composed of ionized gas with a low ionization degree that is well mixed with warm dust and of a spherical bubble surrounding the ejection at 24micron. Taking the evolution of a 60 Mo star and the temporal scale of the bipolar ejection into account, we propose that the observed gas was ejected during an eruption in the luminous blue variable. The star has entered the WR phase recently without apparent signs of interaction between WR-winds and interstellar material.Comment: Accepted for publication in section 6 of Astronomy and Astrophysics. The official date of acceptance is 15/03/2013. 17 pages, 14 figures and 8 table

Estimating Kidney Function in the Critically Ill Patients

Glomerular filtration rate (GFR) is an accepted measure for assessment of kidney function. For the critically ill patient, creatinine clearance is the method of reference for the estimation of the GFR, although this is often not measured but estimated by equations (i.e., Cockroft-Gault or MDRD) not well suited for the critically ill patient. Functional evaluation of the kidney rests in serum creatinine (Crs) that is subjected to multiple external factors, especially relevant overhydration and loss of muscle mass. The laboratory method used introduces variations in Crs, an important fact considering that small increases in Crs have serious repercussion on the prognosis of patients. Efforts directed to stratify the risk of acute kidney injury (AKI) have crystallized in the RIFLE or AKIN systems, based in sequential changes in Crs or urine flow. These systems have provided a common definition of AKI and, due to their sensitivity, have meant a considerable advantage for the clinical practice but, on the other side, have introduced an uncertainty in clinical research because of potentially overestimating AKI incidence. Another significant drawback is the unavoidable period of time needed before a patient is classified, and this is perhaps the problem to be overcome in the near future

Current HHT genetic overview in Spain and its phenotypic correlation: Data from RiHHTa registry

Background: Hereditary hemorrhagic telangiectasia (HHT) is a rare vascular disease with autosomal dominant inheritance. Disease-causing variants in endoglin (ENG) and activin A receptor type II-like 1 (ACVRL1) genes are detected in more than 90% of cases submitted to molecular diagnosis. Methods: We used data from the RiHHTa (Computerized Registry of Hereditary Hemorrhagic Telangiectasia) registry to describe genetic variants and to assess their genotype-phenotype correlation among HHT patients in Spain. Results: By May 2019, 215 patients were included in the RiHHTa registry with a mean age of 52.5 ± 16.5 years and 136 (63.3%) were women. Definitive HHT diagnosis defined by the Curaca&cedil;o criteria were met by 172 (80%) patients. Among 113 patients with genetic test, 77 (68.1%) showed a genetic variant in ACVRL1 and 36 (31.8%) in ENG gene. The identified genetic variants in ACVRL1 and ENG genes and their clinical significance are provided. ACVRL1 mutations were more frequently nonsense (50%) while ENG mutations were more frequently, frameshift (39.1%). ENG patients were significantly younger at diagnosis (36.9 vs 45.7 years) and had pulmonary arteriovenous malformations (AVMs) (71.4% vs 24.4%) and cerebral AVMs (17.6% vs 2%) more often than patients with ACVRL1 variants. Patients with ACVRL1 variants had a higher cardiac index (2.62 vs 3.46), higher levels of hepatic functional blood tests, and anemia (28.5% vs 56.7%) more often than ENG patients. Conclusions: ACVRL1 variants are more frequent than ENG in Spain. ACVRL1 patients developed symptomatic liver disease and anemia more often than ENG patients. Compared to ACVRL1, those with ENG variants are younger at diagnosis and show pulmonary and cerebral AVMs more frequently

Gender differences in Hereditary Hemorrhagic Telangiectasia severity

Background: Gender differences in organ involvement and clinical severity have been poorly described in hereditary hemorrhagic telangiectasia (HHT). The aim of this study was to describe differences in the severity of HHT manifestations according to gender. Methods: Severity was measured according to Epistaxis Severity Score (ESS), Simple Clinical Scoring Index for hepatic involvement, a general HHT-score, needing for invasive treatment (pulmonary or brain arteriovenous malformations -AVMs- embolization, liver transplantation or Young's surgery) or the presence of adverse outcomes (severe anemia, emergency department -ED- or hospital admissions and mortality). Results: One hundred forty-two (58.7%) women and 100 (41.3%) men were included with a mean age of 48.9 ± 16.6 and 49 ± 16.5 years, respectively. Women presented hepatic manifestations (7.1% vs 0%) and hepatic involvement (59.8% vs 47%), hepatic AVMs (28.2% vs 13%) and bile duct dilatation (4.9% vs 0%) at abdominal CT, and pulmonary AVMs at thoracic CT (35.2% vs 23%) more often than men. The Simple Clinical Scoring Index was higher in women (3.38 ± 1.2 vs 2.03 ± 1.2), and more men were considered at low risk of harboring clinically significant liver disease than women (61% vs 25.3%). These differences were mantained when considering HHT1 and HHT2 patients separetely. Duodenal telangiectasia were more frequent in men than women (21% vs 9.8%). Invasive treatments were more frequently needed in women (28.2% vs 16%) but men needed attention at the ED more often than women (48% vs 28.2%), with no differences in ESS, HHT-score, anemia hospital admissions or mortality. Conclusions: HHT women showed more severe hepatic involvement than men, also among HHT1 and HHT2 patients. Women had higher prevalence of pulmonary AVMs and needed invasive procedures more frequently, while men needed attention at the ED more often. These data might help physicians to individualize HHT patients follow-up

In situ architecture of neuronal α-Synuclein inclusions

The molecular architecture of α-Synuclein (α-Syn) inclusions, pathognomonic of various neurodegenerative disorders, remains unclear. α-Syn inclusions were long thought to consist mainly of α-Syn fibrils, but recent reports pointed to intracellular membranes as the major inclusion component. Here, we use cryo-electron tomography (cryo-ET) to image neuronal α-Syn inclusions in situ at molecular resolution. We show that inclusions seeded by α-Syn aggregates produced recombinantly or purified from patient brain consist of α-Syn fibrils crisscrossing a variety of cellular organelles. Using gold-labeled seeds, we find that aggregate seeding is predominantly mediated by small α-Syn fibrils, from which cytoplasmic fibrils grow unidirectionally. Detailed analysis of membrane interactions revealed that α-Syn fibrils do not contact membranes directly, and that α-Syn does not drive membrane clustering. Altogether, we conclusively demonstrate that neuronal α-Syn inclusions consist of α-Syn fibrils intermixed with membranous organelles, and illuminate the mechanism of aggregate seeding and cellular interaction

Investigation of conduction band structure, electron scattering mechanisms and phase transitions in indium selenide by means of transport measurements under pressure

In this work we report on Hall effect, resistivity and thermopower measurements in n-type indium selenide at room temperature under either hydrostatic and quasi-hydrostatic pressure. Up to 40 kbar (= 4 GPa), the decrease of carrier concentration as the pressure increases is explained through the existence of a subsidiary minimum in the conduction band. This minimum shifts towards lower energies under pressure, with a pressure coefficient of about -105 meV/GPa, and its related impurity level traps electrons as it reaches the band gap and approaches the Fermi level. The pressure value at which the electron trapping starts is shown to depend on the electron concentration at ambient pressure and the dimensionality of the electron gas. At low pressures the electron mobility increases under pressure for both 3D and 2D electrons, the increase rate being higher for 2D electrons, which is shown to be coherent with previous scattering mechanisms models. The phase transition from the semiconductor layered phase to the metallic sodium cloride phase is observed as a drop in resistivity around 105 kbar, but above 40 kbar a sharp nonreversible increase of the carrier concentration is observed, which is attributed to the formation of donor defects as precursors of the phase transition.Comment: 18 pages, Latex, 10 postscript figure