NOVEL ANTICOAGULANTS BEYOND HEPARIN AND WARFARIN

Objective: The objective of the study is to know about newer anticoagulant drugs.Method: The Vitamin K adversaries are the single type of oral anticoagulant in the pharmaceutical, and which is endorsed for long-haul utilize.What is more, the Vitamin K adversaries are exceedingly successful, so it is utilized to avert, and treatment of most thrombotic infections in patients,the noteworthy interpatient and intrapatient are additionally fluctuation in measurement response, and the thin restorative medication record andthe more quantities of medication and dietary communications related with these specialists have lead clinicians, patients, and examiners to scanfor different operators. The three new orally controlled anticoagulants are apixaban, dabigatran, and rivaroxaban, which are in the late periods ofprogression and a couple of others they are basically entering (or traveling through), the earlier times of examinations. Those most recent anticoagulantdrugs are being contemplated just for the avoidance and furthermore the treatment of venous for the thromboembolism, and the treatment of intensecoronary conduit disorders, and furthermore the counteractive action of stroke in patients influenced by atrial fibrillation.Results: The pharmacological action of the three new orally controlled anticoagulants is apixaban, dabigatran, and rivaroxaban completely reviewedand compared with warfarin.Conclusion: We are compared the newer anticoagulant with warfarin and discussed about advantages of newer anticoagulants

Heterocyclic dithiocarbazate iron chelators: Fe coordination chemistry and biological activity

The iron coordination and biological chemistry of a series of heterocyclic dithiocarbazate Schiff base ligands is reported with regard to their activity as Fe chelators for the treatment of Fe overload and also cancer. The ligands are analogous to tridentate heterocyclic hydrazone and thiosemicarbazone chelators we have studied previously which bear NNO and NNS donor sets. The dithiocarbazate Schiff base ligands in this work also are NNS chelators and form stable low spin ferric and ferrous complexes and both have been isolated. In addition an unusual hydroxylated ligand derivative has been identified via an Fe-induced oxidation reaction. X-ray crystallographic and spectroscopic characterisation of these complexes has been carried out and also the electrochemical properties have been investigated. All Fe complexes exhibit totally reversible Fe couples in mixed aqueous solvents at potentials higher than found in analogous thiosemicarbazone Fe complexes. The ability of the dithiocarbazate Schiff base ligands to mobilise Fe from cells and also to prevent Fe uptake from transferrin was examined and all ligands were effective in chelating intracellular Fe relative to known controls such as the clinically important Fe chelator desferrioxamine. The Schiff base ligands derived from 2-pyridinecarbaldehyde were non-toxic to SK-N-MC neuroepithelioma (cancer) cells but those derived from the ketones 2-acetylpyridine and di-2-pyridyl ketone exhibited significant antiproliferative activity