Ingestibility and Formulation Quality of Lansoprazole Orally Disintegrating Tablets

Objectives. We evaluated the ingestibility and formulation quality of one branded (formulation A) and five generic (formulations B, C, D, E, and F) lansoprazole orally disintegrating (OD) tablets. Methods. Ingestibility, including the oral disintegrating time, taste, mouth feeling, and palatability, was examined by sensory testing in healthy subjects. Formulation qualities, including salivary stability, gastric acid resistance, and intestinal dissolution behavior, were examined. Results and Discussion. The oral disintegration time of formulation F (52 s) was significantly longer than that of other formulations (32-37 s). More than 90% of subjects did not experience bitterness with formulations A, E, and F, whereas 50% of subjects felt rough and powdery sensations with formulations B, C, and D. More than 80% of subjects suggested that formulations A, E, and F had good palatability. Ingestibility was different between formulations. OD tablets consist of enteric granules containing lansoprazole, which is unstable in gastric acid. Enteric granules of each formulation were stable in artificial saliva and gastric juice. No differences were observed in dissolution behaviors among the formulations, indicating that the formulation quality of the formulations was almost equivalent. Conclusions. This study provides useful information for selecting branded or generic lansoprazole OD tablets for individualized treatments

Shubnikov-de-Haas oscillation and possible modification of effective mass in CeTe3 thin films

Magnetoresistance measurements have been performed in CeTe3 thin film devices in a temperature range from 2.1 to 20 K up to 8 T. A clear Shubnikov-de-Haas oscillation was observed in the whole temperature range. The temperature dependence of the oscillation amplitude was found to deviate from the Lifshitz-Kosevich formula below the magnetic transition temperature at T-N1 approximate to 3 K. This indicates a significant interplay between the magnetic ordering and the conduction electrons, which could lead to a modification of the effective cyclotron mass. By analyzing the temperature dependence of the oscillation amplitude, we have estimated the effective mass, quantum lifetime and quantum mobility of the material both in the paramagnetic and antiferromagnetic states

INSIG2 gene rs7566605 polymorphism is associated with severe obesity in Japanese

The single nucleotide polymorphism (SNP) rs7566605 in the upstream region of the insulin-induced gene 2 (INSIG2) is associated with the obesity phenotype in many Caucasian populations. In Japanese, this association with the obesity phenotype is not clear. To investigate the relationship between rs7566605 and obesity in Japanese, we genotyped rs7566605 from severely obese subjects [n = 908, body mass index (BMI) ≥ 30 kg/m2] and normal-weight control subjects (n = 1495, BMI < 25 kg/m2). A case–control association analysis revealed that rs7566605 was significantly associated with obesity in Japanese. The P value in the minor allele recessive mode was 0.00020, and the odds ratio (OR) adjusted for gender and age was 1.61 [95% confidential interval (CI) = 1.24–2.09]. Obesity-associated phenotypes, which included the level of BMI, plasma glucose, hemoglobin A1c, total cholesterol, triglycerides, high-density lipoprotein (HDL) cholesterol, and blood pressure, were not associated with the rs7566605 genotype. Thus, rs7566605 in the upstream region of the INSIG2 gene was found to be associated with obesity, i.e., severe obesity, in Japanese

Higher harmonic resistance oscillations in micro-bridge superconducting Nb ring

We studied resistance oscillations in two types of superconducting mesoscopic Nb rings. In a simple superconducting ring device, a resistance oscillation with a period of the quantized magnetic flux h/2e was clearly observed. On the other hand, in a micro-bridge ring device where two-narrow parts are embedded in parallel and work as superconductor-normal metal-superconductor junctions, higher harmonic resistance oscillations were obtained when the measurement current was well-tuned. We argue that such higher harmonic resistance oscillations can be detected even in the micro-bridge Nb superconducting ring device where the device size is much larger than the coherence length of Nb.Comment: 8 pages, 4 figure

Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin C-depleted SMP30/GNL knockout mice,

Keywords: Ascorbic acid Chemiluminescence Gluconolactonase Hydrogen-rich pure water Oxidative stress ROS Senescence marker protein-30 Superoxide Vitamin C a b s t r a c t Hydrogen is an established anti-oxidant that prevents acute oxidative stress. To clarify the mechanism of hydrogen&apos;s effect in the brain, we administered hydrogen-rich pure water (H 2 ) to senescence marker protein-30 (SMP30)/gluconolactonase (GNL) knockout (KO) mice, which cannot synthesize vitamin C (VC), also a well-known anti-oxidant. These KO mice were divided into three groups; recipients of H 2 , VC, or pure water (H 2 O), administered for 33 days. VC levels in H 2 and H 2 O groups were &lt;6% of those in the VC group. Subsequently, superoxide formation during hypoxia-reoxygenation treatment of brain slices from these groups was estimated by a real-time biography imaging system, which models living brain tissues, with Lucigenin used as chemiluminescence probe for superoxide. A significant 27.2% less superoxide formed in the H 2 group subjected to ischemia-reperfusion than in the H 2 O group. Thus hydrogenrich pure water acts as an anti-oxidant in the brain slices and prevents superoxide formation