Pilot study to explain runout distances of debris flow and immature debris flow considering depositing rate

In Japan, many debris flows and sediment-laden floods cause serious damage to human life and property. Effective measures require high-accuracy reproduction and prediction of runout distance (bed variation reach) via numerical simulations. One possible method to increase the accuracy of numerical simulation results involves reviewing the methods used to evaluate depositing rate for flows that contain many different sizes of sediments. This study performed experiments using an artificial channel and high-speed cameras to identify parameters that govern depositing rate. The channel implemented exhibited a change in slope point; thus, the slope of the upper reach differed from the slope of the lower reach. The experiments showed that the equation representing depositing rate is closely related to flow velocity. Additionally, the equation of depositing rate can be determined if other parameters are consistently considered

The Effect of Medical Cooperation in the CKD Patients: 10-Year Multicenter Cohort Study

Introduction: While chronic kidney disease (CKD) is one of the most important contributors to mortality from non-communicable diseases, the number of nephrologists is limited worldwide. Medical cooperation is a system of cooperation between primary care physicians and nephrological institutions, consisting of nephrologists and multidisciplinary care teams. Although it has been reported that multidisciplinary care teams contribute to the prevention of worsening renal functions and cardiovascular events, there are few studies on the effect of a medical cooperation system. Methods: We aimed to evaluate the effect of medical cooperation on all-cause mortality and renal prognosis in patients with CKD. One hundred and sixty-eight patients who visited the one hundred and sixty-three clinics and seven general hospitals of Okayama city were recruited between December 2009 and September 2016, and one hundred twenty-three patients were classified into a medical cooperation group. The outcome was defined as the incidence of all-cause mortality, or renal composite outcome (end-stage renal disease or 50% eGFR decline). We evaluated the effects on renal composite outcome and pre-ESRD mortality while incorporating the competing risk for the alternate outcome into a Fine-Gray subdistribution hazard model. Results: The medical cooperation group had more patients with glomerulonephritis (35.0% vs. 2.2%) and less nephrosclerosis (35.0% vs. 64.5%) than the primary care group. Throughout the follow-up period of 5.59 +/- 2.78 years, 23 participants (13.7%) died, 41 participants (24.4%) reached 50% decline in eGFR, and 37 participants (22.0%) developed end-stage renal disease (ESRD). All-cause mortality was significantly reduced by medical cooperation (sHR 0.297, 95% CI 0.105-0.835, p = 0.021). However, there was a significant association between medical cooperation and CKD progression (sHR 3.069, 95% CI 1.225-7.687, p = 0.017). Conclusion: We evaluated mortality and ESRD using a CKD cohort with a long-term observation period and concluded that medical cooperation might be expected to influence the quality of medical care in the patients with CKD

Pilot study to explain runout distances of debris flow and immature debris flow considering depositing rate

In Japan, many debris flows and sediment-laden floods cause serious damage to human life and property. Effective measures require high-accuracy reproduction and prediction of runout distance (bed variation reach) via numerical simulations. One possible method to increase the accuracy of numerical simulation results involves reviewing the methods used to evaluate depositing rate for flows that contain many different sizes of sediments. This study performed experiments using an artificial channel and high-speed cameras to identify parameters that govern depositing rate. The channel implemented exhibited a change in slope point; thus, the slope of the upper reach differed from the slope of the lower reach. The experiments showed that the equation representing depositing rate is closely related to flow velocity. Additionally, the equation of depositing rate can be determined if other parameters are consistently considered

Investigation of dose-rate effects and cell-cycle distribution under protracted exposure to ionizing radiation for various dose-rates

AbstractDuring exposure to ionizing radiation, sub-lethal damage repair (SLDR) competes with DNA damage induction in cultured cells. By virtue of SLDR, cell survival increases with decrease of dose-rate, so-called dose-rate effects (DREs). Here, we focused on a wide dose-rate range and investigated the change of cell-cycle distribution during X-ray protracted exposure and dose-response curves via hybrid analysis with a combination of in vitro experiments and mathematical modelling. In the course of flow-cytometric cell-cycle analysis and clonogenic assays, we found the following responses in CHO-K1 cells: (1) The fraction of cells in S phase gradually increases during 6 h exposure at 3.0 Gy/h, which leads to radio-resistance. (2) Slight cell accumulation in S and G2/M phases is observed after exposure at 6.0 Gy/h for more than 10 hours. This suggests that an increase of SLDR rate for cells in S phase during irradiation may be a reproducible factor to describe changes in the dose-response curve at dose-rates of 3.0 and 6.0 Gy/h. By re-evaluating cell survival for various dose-rates of 0.186–60.0 Gy/h considering experimental-based DNA content and SLDR, it is suggested that the change of S phase fraction during irradiation modulates the dose-response curve and is possibly responsible for some inverse DREs.</jats:p

A Case of Epidermolysis Bullosa Acquisita Associated with Laryngeal Stenosis

ArticleACTA DERMATO-VENEREOLOGICA.92(1):93-94(2012)journal articl

Proximity Gettering Design of Hydrocarbon–Molecular–Ion–Implanted Silicon Wafers Using Dark Current Spectroscopy for CMOS Image Sensors

We developed silicon epitaxial wafers with high gettering capability by using hydrocarbon&#8722;molecular&#8722;ion implantation. These wafers also have the effect of hydrogen passivation on process-induced defects and a barrier to out-diffusion of oxygen of the Czochralski silicon (CZ) substrate bulk during Complementary metal-oxide-semiconductor (CMOS) device fabrication processes. We evaluated the electrical device performance of CMOS image sensor fabricated on this type of wafer by using dark current spectroscopy. We found fewer white spot defects compared with those of intrinsic gettering (IG) silicon wafers. We believe that these hydrocarbon&#8722;molecular&#8722;ion&#8722;implanted silicon epitaxial wafers will improve the device performance of CMOS image sensors