Modified Conditional Restricted Boltzmann Machines for Query Recommendation in Digital Archives

Digital archives (DAs) usually store diverse expert-level materials. Nowadays, access to DAs is increasing for non-expert users, However, they might have difficulties formulating appropriate search queries to find the necessary information. In response to this problem, we propose a query log-based query recommendation algorithm that provides expert knowledge to non-expert users, thus supporting their information seeking in DAs. The use case considered is one where after users enter some general queries, they will be recommended semantically similar expert-level queries in the query logs. The proposed modified conditional restricted Boltzmann machines (M-CRBMs) are capable of utilizing the rich metadata in DAs, thereby alleviating the sparsity problem that conventional restricted Boltzmann machines (RBMs) will face. Additionally, compared with other CRBM models, we drop a large number of model weights. In the experiments, the M-CRBMs outperform the conventional RBMs when using appropriate metadata, and we find that the recommendation results are relevant to the metadata fields that are used in M-CRBMs. Through experiments on the Europeana dataset, we also demonstrate the versatility and scalability of our proposed model

Effect of twist angle in spiral-type Ru/CeO2 catalysts on CO2 auto-methanation performance

This study aims to clarify the effect of twist angle in the spiral-type catalyst on CO2 auto-methanation (AM) performance. The spiral-type catalysts with different twist angles of 360°, 540°, 720°, and 1080° were constructed and investigated for their methanation properties. By increasing the twist angle, high methanation performance was obtained at the lower temperature range. Furthermore, as a result of the calculation of heat transfer coefficient (U) and Nusselt number (Nu) on the spiral-type catalysts based on their catalytic properties, the U and Nu were enhanced with an increment of twist angles, which would produce a high methanation performance of the spiral-type catalyst. A double-tube reactor with a spiral-type catalyst was constructed to improve catalytic performance in order to avoid loss of generated heat to the outside of the reactor. This system exhibited an excellent AM performance with CO2 conversion of about 66% and methane selectivity of 100% at a severe feed rate of 1600 mL/min due to efficient utilization of heat energy generated from H2 combustion and CO2 methanation

Effect of twist angle in spiral-type Ru/CeO2 catalysts on CO2 auto-methanation performance

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Elevated Plasma Soluble PD-L1 Levels in Out-of-Hospital Cardiac Arrest Patients

Background: A deregulated immune system has been implicated in the pathogenesis of post-cardiac arrest syndrome (PCAS). A soluble form of programmed cell death-1 (PD-1) ligand (sPD-L1) has been found at increased levels in cancer and sustained inflammation, thereby deregulating immune functions. Here, we aim to study the possible involvement of sPD-L1 in PCAS. Methods: Thirty out-of-hospital cardiac arrest (OHCA) patients consecutively admitted to the ER of Mie University Hospital were prospectively enrolled. Plasma concentrations of sPD-L1 were measured by an enzyme-linked immunosorbent assay in blood samples of all 30 OHCA patients obtained during cardiopulmonary resuscitation (CPR). In 13 patients who achieved return-of-spontaneous-circulation (ROSC), sPD-L1 levels were also measured daily in the ICU. Results: The plasma concentrations of sPD-L1 in OHCA were significantly increased; in fact, to levels as high as those observed in sepsis. sPD-L1 levels during CPR correlated with reduced peripheral lymphocyte counts and increased C-reactive protein levels. Of 13 ROSC patients, 7 cases survived in the ICU for more than 4 days. A longitudinal analysis of sPD-L1 levels in the 7 ROSC cases revealed that sPD-L1 levels occurred in parallel with organ failure. Conclusions: This study suggests that ischemia- reperfusion during CPR may aberrantly activate immune and endothelial cells to release sPD-L1 into circulation, which may play a role in the pathogenesis of immune exhaustion and organ failures associated with PCAS

The Lectin-Like Domain of Thrombomodulin Inhibits β1 Integrin-Dependent Binding of Human Breast Cancer-Derived Cell Lines to Fibronectin

Thrombomodulin is a molecule with anti-coagulant and anti-inflammatory properties. Recently, thrombomodulin was reported to be able to bind extracellular matrix proteins, such as fibronectin and collagen; however, whether thrombomodulin regulates the binding of human breast cancer-derived cell lines to the extracellular matrix remains unknown. To investigate this, we created an extracellular domain of thrombomodulin, TMD123-Fc, or domain deletion TM-Fc proteins (TM domain 12-Fc, TM domain 23-Fc) and examined their bindings to fibronectin in vitro by ELISA. The lectin-like domain of thrombomodulin was found to be essential for the binding of the extracellular domain of thrombomodulin to fibronectin. Using a V-well cell adhesion assay or flow cytometry analysis with fluorescent beads, we found that both TMD123-Fc and TMD12-Fc inhibited the binding between β1 integrin of human breast cancer-derived cell lines and fibronectin. Furthermore, TMD123-Fc and TMD12-Fc inhibited the binding of activated integrins to fibronectin under shear stress in the presence of Ca2+ and Mg2+ but not under strong integrin-activation conditions in the presence of Mg2+ without Ca2+. This suggests that thrombomodulin Fc fusion protein administered exogenously at a relatively early stage of inflammation may be applied to the development of new therapies that inhibit the binding of β1 integrin of breast cancer cell lines to fibronectin

Incidence and factor analysis for the heat-related illness on the Tokyo 2020 Olympic and Paralympic Games

Introduction Among the 43 venues of Tokyo 2020 Olympic Games (OG) and 33 venues of Paralympic Games (PG) were held, the heat island effect was highly expected to cause heat-related illnesses in the outdoor venues with maximum temperatures exceeding 35°C. However, the actual number of heat-related illness cases during the competition was lower than that was initially expected, and it was unclear under what conditions or environment-related heat illnesses occurred among athletes.Object To clarify the cause and factors contributing to the occurrence of heat-related illness among athletes participating in the Tokyo 2020 Olympic and Paralympic Games.Method This retrospective descriptive study included 15 820 athletes from 206 countries. From 21 July 2021 to 8 August 2021 for the Olympics, and from 24 August 2021 to 5 September 2021 for the Paralympics. The number of heat-related illness cases at each venue, the incidence rate for each event, gender, home continent, as well as the type of competition, environmental factors (such as venue, time, location and wet-bulb globe temperature (WBGT)), treatment factor and the type of competition were analysed.Results More number of heat-related illnesses among athletes occurred at the OG (n=110, 76.3%) than at the PG (n=36, 23.7%). A total of 100 cases (100%) at the OG and 31 cases (86.1%) at the PG occurred at the outdoors venues. In the OG, a total of 50 cases (57.9%) occurred during the competition of marathon running and race walking at Sapporo Odori Park. Six of those, were diagnosed with exertional heat illness and treated with cold water immersion (CWI) at OG and one case at PG. Another 20 cases occurred in athletics (track and field) competitions at Tokyo National Olympic Stadium. In total, 10 cases (10.0%) were diagnosed with severe heat illness in the OG and 3 cases (8.3%) in the PG. Ten cases were transferred to outside medical facilities for further treatment, but no case has been hospitalised due to severe condition. In the factor analysis, venue zone, outdoor game, high WBGT (<28°C) and endurance sports have been found to have a higher risk of moderate and severe heat-related illness (p<0.05). The incidence rate and severity could be attenuated by proper heat-related illness treatment (CWI, ice towel, cold IV transfusion and oral hydration) reduced the severity of the illness, providing summer hot environment sports.Conclusion The Tokyo 2020 Olympic and Paralympic summer games were held. Contrary to expectations, we calculated that about 1 in 100 Olympic athletes suffered heat-related illness. We believe this was due to the risk reduction of heat-related illness, such as adequate prevention and proper treatment. Our experience in avoiding heat-related illness will provide valuable data for future Olympic summer Games

松浦史料博物館所蔵近世演劇関係書目録

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