Evolution of the Irminger Current anticyclones in the Labrador Sea from hydrographic data

Submitted in partial fulfillment of the requirements for the degree of Master of Science at the Massachusetts Institute of Technology and the Woods Hole Oceanographic Institution June 2006The continuous supply of heat and fresh water from the boundaries to the interior of the Labrador Sea plays an important role for the dynamics of the region and in particular, for the Labrador Sea Water formation. Thus, it is necessary to understand the factors governing the exchange of properties between the boundary and interior. A significant fraction of heat and fresh water, needed to balance the annual heat loss and to contribute to the seasonal freshening of the Labrador Sea, is thought to be provided by coherent long-lived anticyclonic eddies shed by the Irminger Current. The population, some properties, rates and direction of propagation of these anomalies are known but the evolution and the mechanism of their decay are still far from obvious. In this work I investigated their water mass properties and evolution under the strong wintertime forcing using hydrographic data from 1990-2004 and a 1-dimensional mixed layer model. There were 50 eddies found in the hydrographic data record, 48 of which were identified as anticyclones. Vertical structure of the eddies was investigated, leading to the categorization of all the anticyclones into three classes: 12 - with a fresh surface layer and no mixed layer, 18 - without a fresh layer and at least one mixed layer, and 18 with ambiguous vertical structure. Four eddies of the second group appeared to have cores extending to as deep as 1500 m vertically and an isopycnal displacement of 400-600 m. A number of eddies without a fresh water cap contained Labrador Sea Water from the previous year at mid-depths

The seasonal and interannual variability of the West Greenland Current system in the Labrador Sea

Submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at the Massachusetts Institute of Technology and the Woods Hole Oceanographic Institution June 2010The Labrador Sea, as one of a few places of deep water formation, plays an important role in the Meridional Overturning Circulation. While the interior of the Labrador Sea, where the deepest convection takes place, is known to experience variability on time scales ranging from days to decades, little is known about the variability of the other components of the Labrador Sea circulation - the boundary current system and the eddies that connect it with the interior. Using various types of in situ data combined with the surface flux and satellite altimetry data products, I studied the variability of both the boundary current system and the eddies on different time scales as well as their influence on the post-convective restratification of the Labrador Sea interior. The analysis presented in the thesis supports the result of the previous theoretical studies that argue that lateral fluxes, driven by the boundary current/interior gradients, play an important role in the post-convective restratification of the Labrador Sea. I found that both components of the boundary current, the surface West Greenland Current and the subsurface Irminger Current, have a strong seasonal cycle. In the spring both the West Greenland and Irminger Currents are colder and fresher than in the fall. However, the West Greenland Current is faster and thicker in the spring while the Irminger Current is the fastest and thickest in the fall. My analysis suggests that the observed seasonal changes in the velocity are primarily due to the baroclinic component of the current while the barotropic component remains nearly unchanged. The Subpolar Gyre, and the Labrador Sea in particular, have experienced a decline in the circulation accompanied by the warming of the water column over the last decades. I found that a similar trend is seen in the West Greenland Current system which slowed down from 1992 to 2004, primarily due to a decrease in the barotropic flow. At the same time, the subsurface Irminger Current has become warmer, saltier, and lighter, something that is also reflected in the properties of the eddies. Two years exhibited pronounced anomalies: in 1997 and 2003 the velocity, temperature and salinity of the Irminger Current abruptly increase with respect to the overall trend. Finally, I discuss the impacts of the boundary current changes on the lateral fluxes that are responsible for the restratification of the Labrador Sea and the properties of the interior.The financial support for my research came from the Academic Programs Office and from the NSF grants OCE-0424492 and OCE-0137023

Seasonal and interannual variability of the West Greenland Current System in the Labrador Sea in 1993–2008

Author Posting. © American Geophysical Union, 2015. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research: Oceans 120 (2015): 1318–1332, doi:10.1002/2014JC010386.The West Greenland Current System (WGCS) transports heat and freshwater into the Labrador Sea, influencing the formation of Labrador Sea Water, a key component of the Atlantic Meridional Overturning Circulation. Notwithstanding its importance, relatively little is known about the structure and transport of this current system and its seasonal and interannual variability. Here we use historical hydrographic data from 1992 to 2008, combined with AVISO satellite altimetry, to diagnose the mean properties as well as seasonal and interannual variability of the boundary current system. We find that while the surface, fresh, cold West Greenland Current is amplified in summer, the subsurface warm, salty Irminger Current has maximum transport in winter, when its waters are also warmer and saltier. Seasonal changes in the total transport are thus mostly due to changes in the baroclinic structure of the current. By contrast, we find a trend toward warmer/saltier waters and a slowdown of the WGCS, within the period studied. The latter is attributed to changes in the barotropic component of the current. Superimposed on this trend, warm and salty anomalies transit through the system in 1997 and 2003 and are associated with a rapid increase in the transport of the boundary current due to changes in the baroclinic component. The boundary current changes precede similar changes in the interior with a 1–2 year lag, indicating that anomalies advected into the region by the boundary current can play an important role in the modulation of convection in the Labrador Sea.T.R. and F.S. were supported by NSF OCE grants 0525929 and 0850416. A.B. was supported by NSF OCE grant 0623192.2015-08-2

Irminger Current Anticyclones in the Labrador Sea observed in the hydrographic record, 1990-2004

Author Posting. © Sears Foundation for Marine Research, 2009. This article is posted here by permission of Sears Foundation for Marine Research for personal use, not for redistribution. The definitive version was published in Journal of Marine Research 67 (2009): 361-384, doi:10.1357/002224009789954739.A significant fraction of the lateral heat transport into the Labrador Sea's interior, needed to balance the net heat loss to the atmosphere, is attributed to the Irminger Current Anticyclones. These mesoscale eddies advect warm, salty boundary current water, of subtropical origin, from the boundary current to the interior— but when or how they release their anomalous heat content has not been previously investigated. In this study, we discuss the seasonal and interannual evolution of these anticyclones as inferred from the analysis of hydrographic data from the Labrador Sea from 1990 to 2004. The 29 identified anticyclones fall into two categories, which we refer to as unconvected and convected. Unconvected anticyclones have properties that are close to those of the boundary current, including a fresh surface layer, and they are found near the boundaries and never observed in winter. Convected anticyclones, on the other hand, contain a mixed layer, lack a freshwater cap and are observed throughout the year. Using a one-dimensional mixing model, it is shown that the convected eddies are those Irminger Current Anticyclones that have been modified by the large winter buoyancy loss of the region. This provides evidence that such eddies can survive the strong winter buoyancy loss in the Labrador Sea and that their anomalous heat and salt content is not trivially mixed into the Sea's interior. Finally, we observe a clear trend in the eddies' properties toward warmer and saltier conditions after 1997 reflecting changes in the source waters and the reduced atmospheric forcing over the Labrador Sea.The work was funded by National Science Foundation grant number OCE-0525929

Evidence for low-temperature antiferromagnetic phase transition in Ising singlet magnet KTb(WO₄)₂

The magnetic susceptibility and magnetization measured along the b axis of a KTb(WO₄)₂ single crystal was investigated experimentally in the temperature range 70 mK–6 K and in magnetic fields up to 8 T. The results allow us to make conclusion that singlet magnet KTb(WO₄)₂ undergoes an antiferromagnetic phase transition Tc = 0.65 K

Bacterial Siderophores: Structure, Functions, and Role in the Pathogenesis of Infections

This review systematizes and analyzes the data published over the past decade, devoted to the study of low-molecular-weight high affinity iron chelators – siderophores. Siderophores, which are found in bacteria, fungi and mammals, are able to extract iron from insoluble inorganic compounds, and in the host organism – from complexes with proteins that perform the function of nonspecific protection of mammals from infections. The extracted iron is delivered to cells through surface protein receptors specific for each siderophore, as well as various protein transport systems that make up membranes. Siderophores play an important role in virulence in pathogenic bacteria, performing many functions in the host organism, in addition to providing microbes with iron and other biological metals. They participate in the storage of excess iron, toxic to cells, protect bacteria from reactive oxygen compounds, compete for iron with phagocytes, and have a harmful effect on host cells, acting as secreted bacterial toxin in some cases. Bacterial siderophores perform a signaling function and regulate both, their own synthesis and the synthesis of other virulence factors. Many pathogenic bacteria produce several siderophores that are active under different conditions, against various sources of iron in the host organism and at different stages of infectious process. The review presents the results of the experimental studies aimed at elucidating the structure and diverse functions of bacterial siderophores, the mechanisms of their biosynthesis and regulation of expression, as well as the role of these molecules in the physiology and virulence of pathogenic bacteria. Special emphasis is put on siderophores of bacteria causing particularly dangerous infections

The Role of the Yersiniachelin Siderophore in the Physiology of <i>Yersinia pestis</i>

Pathogenic bacteria use low-molecular-weight iron chelators – siderophores – to assimilate iron in the host body. Being recognized as virulence factors, these molecules, differing in structural and functional properties, are the subject of the most intensive research in medical microbiology. The present study is devoted to the investigation of yersiniachelin siderophore (Ych) found in the causative agent of plague, Yersinia pestis. The aim of the work was to clarify the role of Ych in the physiology of Y. pestis by comparing the properties of three strains of the plague microbe, differing in Ych production. Materials and methods. Three variants of Y. pestis EV76 strain were used in the experiments: parent strain Y. pestis EV76, its mutant that does not produce Ych due to deletion of three siderophore biosynthesis genes (analogues of ypo1530–1532 in Y. pestis CO92 strain) and a complemented mutant that was transformed by a recombinant pSC-A-5EV plasmid containing Ych biosynthesis genes cloned into the high-copy plasmid vector pSC-A-amp/kan. Comparative analysis of the three strains was carried out in terms of colony morphology, siderophore activity, growth rate, and sensitivity to hydrogen peroxide. Results and discussion. The comparison of these strains has revealed that the secretion of Ych by bacteria at 26 °С ensures the assimilation of iron. At 37 °С, Ych is not secreted into the medium and protects bacteria from the bactericidal action of reactive oxygen compounds. Thus, the study shows that yersiniachelin is able to stimulate the assimilation of iron by bacteria under iron-deficit conditions and has antioxidant properties

Circulating microRNAs in lung cancer: prospects for diagnosis, prognosis, and prediction of antitumor treatment efficacy

The review considers the main techniques to extract microRNA (miRNA) from various biological fluids (in particular, the serum and plasma), approaches to the analysis of miRNA concentration and composition, and methods to normalize the results in data analyses. Advantages and drawbacks of the methods are described. Special attention is given to circulating miRNAs, which can be used as markers for minimally invasive diagnosis, prediction of antitumor treatment efficacy, and disease prognosis in lung cancer. The review discusses the prospects and limitations that arise as the clinical significance is evaluated for miRNAs as potential tumor markers and a better understanding is gained for the roles various miRNAs play in the pathogenesis of lung cancer

Force Field Analysis and K. Lewin’s Change Model as leverages of “Lean University” principles in student environment

Background. Lean production technologies in medical institutions are deployed within the national program “Healthcare”. The vocational training of medical personnel in lean technologies have become a timely demand. Educational organisations are achieving this goal via including philosophy, the principles and techniques of lean production in curricula and involving students and residents in project activities.Objectives. Assessment of driving and restraining forces in the student community with respect to project activities within the “Lean University” concept initiative.Methods. The study unitised Force Field Analysis and the Kurt Lewin’s 3-stage Model of Change. The sample comprised students of Kuban State Medical University, Ministry of Health of the Russian Federation. An anonymous survey of students from two study cohorts (with and without experience in the “Lean University” activities) revealed the main driving and restraining factors shaping the students’ attitude towards the “Lean University” initiative.Results. A total of 1508 students were surveyed. The survey revealed the following major driving forces that motivate students’ project activities: the intention to solve a problem that affects students (60%, experienced cohort), the intention to gain new experience, knowledge and skills (40%, inexperienced cohort). The intention to benefit a university was the second motivating in both respondent cohorts (57 and 36%, respectively).The restraining factors for students to participate are: a lack of free time (over 60 respondents in each cohort), lack of understanding of the project’s matter (over 30% in each cohort), erroneous belief in the infeasibility of remote participation (no or seldom visits to the project’s office) (19% of respondents in inexperienced cohort).Conclusion. Guidelines have been formulated to encourage the student community to develop practical skills in lean technologies for improving the overall internal processes efficiency at a higher educational institution

Circulating DNA-markers in lung cancer: changes in retrotrasposons methylation status in response therapy and during the post-treatment follow-up

Malignant cell transformation is accompanied by two processes of DNA methylation changes