665 research outputs found
Recommended from our members
NBS monograph
From Abstract: "The results of an investigation of lightweight, precast cellular concrete planks are given. Fire tests were made of two floor and five roof specimens made up of these planks. Variables, included density of the cellular concrete, thickness and span of the planks, reinforcement, and cover for the latter.
Disseminated histiocytoses biomarkers beyond BRAFV600E: frequent expression of PD-L1.
The histiocytoses are rare tumors characterized by the primary accumulation and tissue infiltration of histiocytes and dendritic cells. Identification of the activating BRAFV600E mutation in Erdheim-Chester disease (ECD) and Langerhans cell histiocytosis (LCH) cases provided the basis for the treatment with BRAF and/or MEK inhibitors, but additional treatment options are needed. Twenty-four cases of neoplastic histiocytic diseases [11 extrapulmonary LCH, 4 ECD, 4 extranodal Rosai-Dorfman disease (RDD), 3 follicular dendritic cell sarcoma (FDCS), 1 histiocytic sarcoma (HS) and 1 blastic plasmacytoid dendritic cell neoplasm (BPDCN)] were analyzed using immunohistochemical and mutational analysis in search of biomarkers for targeted therapy. BRAF V600E mutations were detected in 4/11 LCH and 4/4 ECD cases. A pathogenic PTEN gene mutation and loss of PTEN protein expression were identified in the case of HS. Increased expression of PD-L1 (≥2+/≥5%) was seen in 3/4 ECD, 7/8 LCH, 3/3 FDCS and 1/1 HS, with overall 81% concordance between 2 antibodies used in the study (SP142 vs. MAB1561 clone). These results show for the first time significant expression of the PD-L1 immune checkpoint protein in these disorders, which may provide rationale for addition of immune check-point inhibitors in treatment of disseminated and/or refractory histiocytoses
Constrained modelling of instrumental radial velocity drift in precision Radial Velocity Spectrometers: Application to HPF
For precise measurement of the radial velocity change in a star, the precision of the wavelength solution is 4 orders more important than accuracy of the wavelength solution. Since the absolute wavelength solution model of a multi-order echelle spectrographs require a large number of parameters, it is better to track the change in wavelength solution over time instead of refitting the complete wavelength solution without any constrains. For stabilized spectrographs like The Habitable-Zone Planet Finder (HPF) and NEID, these changes in wavelength solution are significantly low order and can be modeled with only a few parameters. Table 1, shows an example of low order changes to dispersion solution we expect from various physical mechanisms in HPF or NEID
Evidence for He I 10830 \AA~ absorption during the transit of a warm Neptune around the M-dwarf GJ 3470 with the Habitable-zone Planet Finder
Understanding the dynamics and kinematics of out-flowing atmospheres of hot
and warm exoplanets is crucial to understanding the origins and evolutionary
history of the exoplanets near the evaporation desert. Recently, ground based
measurements of the meta-stable Helium atom's resonant absorption at 10830
\AA~has become a powerful probe of the base environment which is driving the
outflow of exoplanet atmospheres. We report evidence for the He I 10830 \AA~in
absorption (equivalent width \AA) in the exosphere of
a warm Neptune orbiting the M-dwarf GJ 3470, during three transits using the
Habitable Zone Planet Finder (HPF) near infrared spectrograph. This marks the
first reported evidence for He I 10830 \AA\, atmospheric absorption for a
planet orbiting an M-dwarf. Our detected absorption is broad and its
blueshifted wing extends to -36 km/sec, the largest reported in the literature
to date. We modelled the state of Helium atoms in the exosphere of GJ3470b
based on assumptions on the UV and X-ray flux of GJ 3470, and found our
measurement of flux-weighted column density of meta-stable state Helium
, derived from our transit
observations, to be consistent with model, within its uncertainties. The
methodology developed here will be useful to study and constrain the
atmospheric outflow models of other exoplanets like GJ 3470b which are near the
edge of the evaporation desert.Comment: Accepted in Ap
Solar Contamination in Extreme-precision Radial-velocity Measurements: Deleterious Effects and Prospects for Mitigation
Solar contamination, due to moonlight and atmospheric scattering of sunlight, can cause systematic errors in stellar radial velocity (RV) measurements that significantly detract from the ~10 cm s−1 sensitivity required for the detection and characterization of terrestrial exoplanets in or near habitable zones of Sun-like stars. The addition of low-level spectral contamination at variable effective velocity offsets introduces systematic noise when measuring velocities using classical mask-based or template-based cross-correlation techniques. Here we present simulations estimating the range of RV measurement error induced by uncorrected scattered sunlight contamination. We explore potential correction techniques, using both simultaneous spectrometer sky fibers and broadband imaging via coherent fiber imaging bundles, that could reliably reduce this source of error to below the photon-noise limit of typical stellar observations. We discuss the limitations of these simulations, the underlying assumptions, and mitigation mechanisms. We also present and discuss the components designed and built into the NEID (NN-EXPLORE Exoplanet Investigations with Doppler spectroscopy) precision RV instrument for the WIYN 3.5 m telescope, to serve as an ongoing resource for the community to explore and evaluate correction techniques. We emphasize that while "bright time" has been traditionally adequate for RV science, the goal of 10 cm s−1 precision on the most interesting exoplanetary systems may necessitate access to darker skies for these next-generation instruments
Impact of crosshatch patterns in H2RGs on high-precision radial velocity measurements: exploration of measurement and mitigation paths with the Habitable-Zone Planet Finder
Teledyne’s H2RG detector images suffer from crosshatch like patterns, which arise from subpixel quantum efficiency (QE) variation. We present our measurements of this subpixel QE variation in the Habitable-Zone Planet Finder’s H2RG detector. We present a simple model to estimate the impact of subpixel QE variations on the radial velocity and how a first-order correction can be implemented to correct for the artifact in the spectrum. We also present how the HPF’s future upgraded laser frequency comb will enable us to implement this correction
Bounding the mass of the graviton using gravitional-wave observations of inspiralling compact binaries
If gravitation is propagated by a massive field, then the velocity of
gravitational waves (gravitons) will depend upon their frequency and the
effective Newtonian potential will have a Yukawa form. In the case of
inspiralling compact binaries, gravitational waves emitted at low frequency
early in the inspiral will travel slightly slower than those emitted at high
frequency later, modifying the phase evolution of the observed inspiral
gravitational waveform, similar to that caused by post-Newtonian corrections to
quadrupole phasing. Matched filtering of the waveforms can bound such
frequency-dependent variations in propagation speed, and thereby bound the
graviton mass. The bound depends on the mass of the source and on noise
characteristics of the detector, but is independent of the distance to the
source, except for weak cosmological redshift effects. For observations of
stellar-mass compact inspiral using ground-based interferometers of the
LIGO/VIRGO type, the bound on the graviton Compton wavelength is of the order
of km, about double that from solar-system tests of Yukawa
modifications of Newtonian gravity. For observations of super-massive black
hole binary inspiral at cosmological distances using the proposed laser
interferometer space antenna (LISA), the bound can be as large as km. This is three orders of magnitude weaker than model-dependent
bounds from galactic cluster dynamics.Comment: 8 pages, RevTeX, submitted to Phys. Rev.
Persistent starspot signals on M dwarfs: multi-wavelength Doppler observations with the Habitable-zone Planet Finder and Keck/HIRES
Young, rapidly-rotating M dwarfs exhibit prominent starspots, which create
quasiperiodic signals in their photometric and Doppler spectroscopic
measurements. The periodic Doppler signals can mimic radial velocity (RV)
changes expected from orbiting exoplanets. Exoplanets can be distinguished from
activity-induced false positives by the chromaticity and long-term incoherence
of starspot signals, but these qualities are poorly constrained for
fully-convective M stars. Coherent photometric starspot signals on M dwarfs may
persist for hundreds of rotations, and the wavelength dependence of starspot RV
signals may not be consistent between stars due to differences in their
magnetic fields and active regions. We obtained precise multi-wavelength RVs of
four rapidly-rotating M dwarfs (AD Leo, G 227-22, GJ 1245B, GJ 3959) using the
near-infrared (NIR) Habitable-zone Planet Finder, and the optical Keck/HIRES
spectrometer. Our RVs are complemented by photometry from Kepler, TESS, and the
Las Cumbres Observatory (LCO) network of telescopes. We found that all four
stars exhibit large spot-induced Doppler signals at their rotation periods, and
investigated the longevity and optical-to-NIR chromaticity for these signals.
The phase curves remain coherent much longer than is typical for Sunlike stars.
Their chromaticity varies, and one star (GJ 3959) exhibits optical and NIR RV
modulation consistent in both phase and amplitude. In general, though, we find
that the NIR amplitudes are lower than their optical counterparts. We conclude
that starspot modulation for rapidly-rotating M stars frequently remains
coherent for hundreds of stellar rotations, and gives rise to Doppler signals
that, due to this coherence, may be mistaken for exoplanets.Comment: Accepted for publication in the Astrophysical Journa
- …