332 research outputs found

    Observation of topologically protected helical edge modes in Kagome elastic plates

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    The investigation of topologically protected waves in classical media has opened unique opportunities to achieve exotic properties like one-way phonon transport, protection from backscattering and immunity to imperfections. Contrary to acoustic and electromagnetic domains, their observation in elastic solids has so far been elusive due to the presence of both shear and longitudinal modes and their modal conversion at interfaces and free surfaces. Here we report the experimental observation of topologically protected helical edge waves in elastic media. The considered structure consists of an elastic plate patterned according to a Kagome architecture with an accidental degeneracy of two Dirac cones induced by drilling through holes. The careful breaking of symmetries couples the corresponding elastic modes which effectively emulates spin orbital coupling in the quantum spin Hall effect. The results shed light on the topological properties of the proposed plate waveguide and opens avenues for the practical realization of compact, passive and cost-effective elastic topological waveguides

    Role of protein kinase CK2 in antitumor drug resistance

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    IMECE2003-41552 VIBRATION AND SOUND RADIATION OF SANDWICH BEAMS WITH HONEYCOMB TRUSS CORE

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    ABSTRACT The vibrations of and the sound radiation from sandwich beams with truss core are here analyzed. The structure of the core is composed of a sequence of identical unit cells repeating along the beam length and across the core thickness. Each cell is composed of beam elements assembled to form a frame structure. Layouts with honeycomb patterns arranged through the thickness of the core are considered. This design represents an alternative with respect to the traditional application of honeycombs in sandwich construction. The proposed configuration provides sandwich beams with interesting structural as well as acoustic characteristics. A spectral finite element model is developed to evaluate the structural and the acoustic behavior of the considered class of sandwich beams. The spectral model can be easily coupled with a Fourier Transform based analysis of the sound radiated by the fluidloaded structure. The model predicts the performance of beams with various core configurations. The comparison is carried out in terms of vibration and sound radiation in an unbounded acoustic half-plane. Hexagonal and re-entrant honeycomb configurations are considered to study the effects of core geometry on structural response and acoustic radiation

    Elasto-static micropolar behavior of a chiral auxetic lattice

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    Auxetic materials expand when stretched, and shrink when compressed. This is the result of a negative Poisson's ratio ν. Isotropic configurations with ν≈−1 have been designed and are expected to provide increased shear stiffness G. This assumes that Young's modulus and ν can be engineered independently. In this article, a micropolar-continuum model is employed to describe the behavior of a representative auxetic structural network, the chiral lattice, in an attempt to remove the indeterminacy in its constitutive law resulting from ν=−1. While this indeterminacy is successfully removed, it is found that the shear modulus is an independent parameter and, for certain configurations, it is equal to that of the triangular lattice. This is remarkable as the chiral lattice is subject to bending deformation of its internal members, and thus is more compliant than the triangular lattice which is stretch dominated. The derived micropolar model also indicates that this unique lattice has the highest characteristic length scale lc of all known lattice topologies, as well as a negative first Lamé constant without violating bounds required for thermodynamic stability. We also find that hexagonal arrangements of deformable rings have a coupling number N=1. This is the first lattice reported in the literature for which couple-stress or Mindlin theory is necessary rather than being adopted a priori

    Validation of Two Nonlinear System Identification Techniques Using an Experimental Testbed

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    The identification of a nonlinear system is performed using experimental data and two different techniques, i.e. a method based on the Wavelet transform and the Restoring Force Surface method. Both techniques exploit the system free response and result in the estimation of linear and nonlinear physical parameters

    pLG72 modulates intracellular D-serine levels through its interaction with D-amino acid oxidase - Effect on schizophrenia susceptibility

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    Human genes coding for pLG72 and d-amino acid oxidase have recently been linked to the onset of schizophrenia. pLG72 was proposed as an activator of the human FAD-containing flavoprotein d-amino acid oxidase (hDAAO). In the brain this oxidizes d-serine, a potent activator of N-methyl-d-aspartate receptor. We have investigated the mechanistic regulation of hDAAO by pLG72. Immunohistochemical analyses revealed that hDAAO and pLG72 are both expressed in astrocytes of the human cortex, where they most likely interact, considering their partial overlapping subcellular distribution and their coimmunoprecipitation. We demonstrated that the specific in vitro interaction of the two proteins yields a complex composed of 2 hDAAO homodimers and 2 pLG72 molecules. Binding of pLG72 did not affect the kinetic properties and FAD binding ability of hDAAO; instead, a time-dependent loss of hDAAO activity in the presence of an excess of pLG72 was found. The binding affects the tertiary structure of hDAAO, altering the amount of the active form. We finally demonstrated that overexpression of hDAAO in glioblastoma cells decreases the levels of d-serine, an effect that is null when pLG72 is coexpressed. These data indicate that pLG72 acts as a negative effector of hDAAO. Therefore, a decrease in the synaptic concentration of d-serine as the result of an anomalous increase in hDAAO activity related to hypoexpression of pLG72 may represent a molecular mechanism by which hDAAO and pLG72 are involved in schizophrenia susceptibility

    Generalized continuum model for the analysis of nonlinear vibrations of taut strings with microstructure

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    Classical continuum models are unable to capture the response of a microstructured solid when the scale effect is relevant. In vibration analysis, this limitation appears when the solid undergoes vibrations of wavelength that approaches the characteristic length of the microstructure. A discrete model may be formulated to account for this effect, but this comes at the expenses of high computational costs. For example, scale effects are relevant in strings employed in sensing applications which often rely on information gathered in the nonlinear dynamic regime. In this work, we study the dynamic behavior of a taut string modeled as a lattice of particles linked to first neighbors by linear springs. We develop an inertia-gradient generalized continuum model of the chain, which undergoes nonlinear vibrations. Unlike the corresponding classical continuum model, enrichment of the kinetic energy density with the characteristic length of the microstructure permits the model to capture short-wavelength vibrations. Comparison of the response predicted by the continuum models highlights that the generalized model provides better estimations of the dynamic response of the considered microstructured string in the nonlinear regime and at short wavelengths.Program during academic year 2017-18. This work was supported by the Ministerio de Economía y Competitividad de España (grant numbers DPI2014-57989-P and BES-2015-073720).Publicad
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