39 research outputs found
On the thickness of the double layer in ionic liquids
In this study, we examined the thickness of the electrical double layer (EDL)
in ionic liquids using density functional theory (DFT) calculations and
molecular dynamics (MD) simulations. We focused on the BF4- anion adsorption
from 1-ethyl-3-methylimidazolium tetrafluoroborate (EMImBF4) ionic liquid on
the Au(111) surface. At both DFT and MD levels, we evaluated the
capacitance-potential dependence for the Helmholtz model of the interface.
Using MD simulations, we also explored a more realistic, multilayer EDL model
accounting for the ion layering. Concurrent analysis of the DFT and MD results
provides a ground for thinking whether the electrical double layer in ionic
liquids is one- or multi-ionic-layer thick
The modENCODE Data Coordination Center: lessons in harvesting comprehensive experimental details.
The model organism Encyclopedia of DNA Elements (modENCODE) project is a National Human Genome Research Institute (NHGRI) initiative designed to characterize the genomes of Drosophila melanogaster and Caenorhabditis elegans. A Data Coordination Center (DCC) was created to collect, store and catalog modENCODE data. An effective DCC must gather, organize and provide all primary, interpreted and analyzed data, and ensure the community is supplied with the knowledge of the experimental conditions, protocols and verification checks used to generate each primary data set. We present here the design principles of the modENCODE DCC, and describe the ramifications of collecting thorough and deep metadata for describing experiments, including the use of a wiki for capturing protocol and reagent information, and the BIR-TAB specification for linking biological samples to experimental results. modENCODE data can be found at http://www.modencode.org
A clinical example of the discrepancy between the diagnoses of the prehospital and hospital stages in acute gastroenteritis and ectopic pregnancy
The aim of the study - to observe and describe a clinical case of a discrepancy between the diagnoses of the prehospital and hospital stages in acute gastroenteritis and ectopic pregnancy.Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ - Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΠ΅ ΠΈ ΠΎΠΏΠΈΡΠ°Π½ΠΈΠ΅ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠ»ΡΡΠ°Ρ ΡΠ°ΡΡ
ΠΎΠΆΠ΄Π΅Π½ΠΈΡ Π΄ΠΈΠ°Π³Π½ΠΎΠ·ΠΎΠ² Π΄ΠΎΠ³ΠΎΡΠΏΠΈΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΈ Π³ΠΎΡΠΏΠΈΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΡΠ°ΠΏΠΎΠ² ΠΏΡΠΈ ΠΎΡΡΡΠΎΠΌ Π³Π°ΡΡΡΠΎΡΠ½ΡΠ΅ΡΠΈΡΠ΅ ΠΈ Π²Π½Π΅ΠΌΠ°ΡΠΎΡΠ½ΠΎΠΈΜ Π±Π΅ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΡΡΠΈ
modMine: flexible access to modENCODE data.
In an effort to comprehensively characterize the functional elements within the genomes of the important model organisms Drosophila melanogaster and Caenorhabditis elegans, the NHGRI model organism Encyclopaedia of DNA Elements (modENCODE) consortium has generated an enormous library of genomic data along with detailed, structured information on all aspects of the experiments. The modMine database (http://intermine.modencode.org) described here has been built by the modENCODE Data Coordination Center to allow the broader research community to (i) search for and download data sets of interest among the thousands generated by modENCODE; (ii) access the data in an integrated form together with non-modENCODE data sets; and (iii) facilitate fine-grained analysis of the above data. The sophisticated search features are possible because of the collection of extensive experimental metadata by the consortium. Interfaces are provided to allow both biologists and bioinformaticians to exploit these rich modENCODE data sets now available via modMine
Respiratory diseases in children: assessment of the stage of emergency medical care
The aim of the study to analyze the frequency and structure of respiratory system diseases in children, the clinical picture at the stage of emergency medical care.Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ β ΠΏΡΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°ΡΡ ΡΠ°ΡΡΠΎΡΡ, ΡΡΡΡΠΊΡΡΡΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΈΜ Π΄ΡΡ
Π°ΡΠ΅Π»ΡΠ½ΠΎΠΈΜ ΡΠΈΡΡΠ΅ΠΌΡ Ρ Π΄Π΅ΡΠ΅ΠΈΜ, ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΡ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΈΜ ΠΊΠ°ΡΡΠΈΠ½Ρ Π½Π° ΡΡΠ°ΠΏΠ΅ ΡΠΊΠΎΡΠΎΠΈΜ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠΎΠΈΜ ΠΏΠΎΠΌΠΎΡΠΈ
Transcriptome analyses of the Giardia lamblia life cycle
Author Posting. Β© The Author(s), 2010. This is the author's version of the work. It is posted here by permission of Elsevier B.V. for personal use, not for redistribution. The definitive version was published in Molecular and Biochemical Parasitology 174 (2010): 62-65, doi:10.1016/j.molbiopara.2010.05.010.We quantified mRNA abundance from 10 stages in the Giardia lamblia life cycle in vitro using
Serial Analysis of Gene Expression (SAGE). 163 abundant transcripts were expressed
constitutively. 71 transcripts were upregulated specifically during excystation and 42 during
encystation. Nonetheless, the transcriptomes of cysts and trophozoites showed major
differences. SAGE detected co-expressed clusters of 284 transcripts differentially expressed in
cysts and excyzoites and 287 transcripts in vegetative trophozoites and encysting cells. All
clusters included known genes and pathways as well as proteins unique to Giardia or
diplomonads. SAGE analysis of the Giardia life cycle identified a number of kinases,
phosphatases, and DNA replication proteins involved in excystation and encystation, which
could be important for examining the roles of cell signaling in giardial differentiation. Overall,
these data pave the way for directed gene discovery and a better understanding of the biology
of Giardia lamblia.BJD, DSR, and FDG were supported by NIH grants AI42488, GM61896, DK35108, and
AI051687. DP and SGS were supported by grants from the Swedish Natural Science Research
Council, the Swedish Medical Research Council, and the Karolinska Institutet. AGM, SRB,
SPP, and MJC were supported by NIH grant AI51089 and by the Marine Biological Laboratoryβs
Program in Global Infectious Diseases, funded by the Ellison Medical Foundation
Features of providing medical care to patients with acute cerebrovascular accident at the prehospital stage
The purpose of the study is to analyze the features of the diagnosis of patients with acute cerebrovascular accident at the prehospital stage, affecting their routing, taking into account the use of neurological scales.Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ β ΠΏΡΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°ΡΡ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΠΎΡΡΡΡΠΌ Π½Π°ΡΡΡΠ΅Π½ΠΈΠ΅ΠΌ ΠΌΠΎΠ·Π³ΠΎΠ²ΠΎΠ³ΠΎ ΠΊΡΠΎΠ²ΠΎΠΎΠ±ΡΠ°ΡΠ΅Π½ΠΈΡ (ΠΠΠΠ) Π½Π° Π΄ΠΎΠ³ΠΎΡΠΏΠΈΡΠ°Π»ΡΠ½ΠΎΠΌ ΡΡΠ°ΠΏΠ΅, Π²Π»ΠΈΡΡΡΠ΅ΠΉ Π½Π° ΠΈΡ
ΠΌΠ°ΡΡΡΡΡΠΈΠ·Π°ΡΠΈΡ Ρ ΡΡΠ΅ΡΠΎΠΌ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ Π½Π΅Π²ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠΊΠ°Π»
The clinical, epidemiological and laboratory characteristics of acute viral hepatitis Π‘ whith users of introvenous drugs
Viral hepatitis Π‘ remains a global problem of modern health care. It accounts for up to 20% of acute hepatitis, 70% of chronic hepatitis, 40% of liver cirrhosis in the terminal stage, from 15-20 to 60-70% of cases of hepatocellular carcinoma. The virus of hepatitis Π‘ has the highest horiogen potential. The aggravating factors have the significantly influence on the pathogenesis and clinical manifestations of HCV - infection, such as: alcoholism, drug addiction, medicinal liver disease, HBV/HCV mixed-infection. The patients with HCV, using drugs, have a shorter incubation period, more pronounced cytolytic and cholestatic syndromes, which affects on the clinical course and prognosis. This dictates the necessity to study the flow characteristics of HCV in drug users.ΠΠΈΡΡΡΠ½ΡΠΉ Π³Π΅ΠΏΠ°ΡΠΈΡ Π‘ (ΠΠΠ‘) ΠΏΡΠΎΠ΄ΠΎΠ»ΠΆΠ°Π΅Ρ ΠΎΡΡΠ°Π²Π°ΡΡΡΡ Π³Π»ΠΎΠ±Π°Π»ΡΠ½ΠΎΠΉ ΠΏΡΠΎΠ±Π»Π΅ΠΌΠΎΠΉ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠ³ΠΎ Π·Π΄ΡΠ°Π²ΠΎΠΎΡ
ΡΠ°Π½Π΅Π½ΠΈΡ. ΠΠ° Π΅Π³ΠΎ Π΄ΠΎΠ»Ρ ΠΏΡΠΈΡ
ΠΎΠ΄ΠΈΡΡΡ Π΄ΠΎ 20 % ΠΎΡΡΡΡΡ
Π³Π΅ΠΏΠ°ΡΠΈΡΠΎΠ², 70% Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
Π³Π΅ΠΏΠ°ΡΠΈΡΠΎΠ², 40% ΡΠΈΡΡΠΎΠ·ΠΎΠ² ΠΏΠ΅ΡΠ΅Π½ΠΈ Π² ΡΠ΅ΡΠΌΠΈΠ½Π°Π»ΡΠ½ΠΎΠΉ ΡΡΠ°Π΄ΠΈΠΈ, ΠΎΡ 15-20 Π΄ΠΎ 60-70 % ΡΠ»ΡΡΠ°Π΅Π² Π³Π΅ΠΏΠ°ΡΠΎΡΠ΅Π»Π»ΡΠ»ΡΡΠ½ΠΎΠΉ ΠΊΠ°ΡΡΠΈΠ½ΠΎΠΌΡ. ΠΠΈΡΡΡ Π³Π΅ΠΏΠ°ΡΠΈΡΠ° Π‘ ΠΎΠ±Π»Π°Π΄Π°Π΅Ρ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ Π²ΡΡΠΎΠΊΠΈΠΌ Ρ
ΡΠΎΠ½ΠΈΠΎΠ³Π΅Π½Π½ΡΠΌ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΠΎΠΌ. ΠΠ° ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅Π· ΠΈ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΏΡΠΎΡΠ²Π»Π΅Π½ΠΈΡΡ
HCV-ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΈ ΡΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠ΅ Π²Π»ΠΈΡΠ½ΠΈΠ΅ ΠΎΠΊΠ°Π·ΡΠ²Π°ΡΡ ΠΎΡΡΠ³ΠΎΡΠ°ΡΡΠΈΠ΅ ΡΠ°ΠΊΡΠΎΡΡ: Π°Π»ΠΊΠΎΠ³ΠΎΠ»ΠΈΠ·ΠΌ, Π½Π°ΡΠΊΠΎΠΌΠ°Π½ΠΈΡ, Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΠΎΠ΅ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΠ΅ ΠΏΠ΅ΡΠ΅Π½ΠΈ, HBV/HCV ΠΌΠΈΠΊΡΡ-ΠΈΠ½ΡΠ΅ΠΊΡΠΈΡ. Π£ Π±ΠΎΠ»ΡΠ½ΡΡ
ΠΠΠ‘, ΡΠΏΠΎΡΡΠ΅Π±Π»ΡΡΡΠΈΡ
Π½Π°ΡΠΊΠΎΡΠΈΠΊΠΈ, ΠΎΡΠΌΠ΅ΡΠ°Π΅ΡΡΡ Π±ΠΎΠ»Π΅Π΅ ΠΊΠΎΡΠΎΡΠΊΠΈΠΉ ΠΈΠ½ΠΊΡΠ±Π°ΡΠΈΠΎΠ½Π½ΡΠΉ ΠΏΠ΅ΡΠΈΠΎΠ΄, Π±ΠΎΠ»Π΅Π΅ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΡΠ΅ ΡΠΈΡΠΎΠ»ΠΈΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΈ Ρ
ΠΎΠ»Π΅ΡΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΠΈΠ½Π΄ΡΠΎΠΌΡ, ΡΡΠΎ ΠΎΠΊΠ°Π·ΡΠ²Π°Π΅Ρ Π²Π»ΠΈΡΠ½ΠΈΠ΅ Π½ΠΈ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ ΠΈ ΠΏΡΠΎΠ³Π½ΠΎΠ· Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ. ΠΡΠΎ Π΄ΠΈΠΊΡΡΠ΅Ρ Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠΎΡΡΡ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠ΅ΠΉ ΡΠ΅ΡΠ΅Π½ΠΈΡ ΠΠΠ‘ Ρ Π½Π°ΡΠΊΠΎΠΏΠΎΡΡΠ΅Π±ΠΈΡΠ΅Π»Π΅ΠΉ
Analysis of patients with acute coronary syndrome without ST segment elevation at the prehospital stage
The aim of the study to analyze the clinical, anamnestic, objective parameters of patients with STEMI at the prehospital stage and the tactics of their management.Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ β ΠΏΡΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°ΡΡ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠ΅, Π°Π½Π°ΠΌΠ½Π΅ΡΡΠΈΡΠ΅ΡΠΊΠΈΠ΅, ΠΎΠ±ΡΠ΅ΠΊΡΠΈΠ²Π½ΡΠ΅ ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΡ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΠΠΠ‘ΠΠST Π½Π° Π΄ΠΎΠ³ΠΎΡΠΏΠΈΡΠ°Π»ΡΠ½ΠΎΠΌ ΡΡΠ°ΠΏΠ΅ ΠΈ ΡΠ°ΠΊΡΠΈΠΊΡ ΠΈΡ
Π²Π΅Π΄Π΅Π½ΠΈΡ