Quantitative analysis of povidone-iodine thin films by X-ray photoelectron spectroscopy and their physicochemical properties

In this study, povidone-iodine (PVP-I) has been formulated as a topical spray to produce a thin film for the controlled release of I2. By means of experimental design, 27 formulations containing glycerol, ethanol, PEG 400, copovidone and HFA 134a as a propellant were prepared. The pH values of all formulations were in the range of 6–7. The viscosity was within the range of 11.9–85.9 mPas. The surface tensions were 20.3 to 24.6 mN m–1 and the contact angles were between 19.3 and 38.7. The assays for the iodine contents were within acceptable range (80–120 %). X-ray photoelectron spectroscopy analysis revealed the ionized form of iodine was much higher than the unionized form. The MIC and MBC values of the PVP-I sprays against Staphylococcus aureus, S. epidermidis and Pseudomonas aeruginosa were higher than that of commercial PVP-I solution. The cytotoxicity study confirmed that the PVP-I spray had lower toxic effects on keratinocytes and fibroblasts compared to the commercial PVP-I solution. The formulation containing 59 % ethanol, 18 % copovidone and 12 % PEG 400 showed good antibacterial activity

Development of a topical mupirocin spray for antibacterial and wound-healing applications

10.1080/03639045.2017.1339077Drug Development and Industrial Pharmacy43101715-172

Development of nanodispersion-based sildenafil metered-dose inhalers stabilized by poloxamer 188: a potential candidate for the treatment of pulmonary arterial hypertension

10.1080/10837450.2019.1650766Pharmaceutical Development and Technology24101218-122