Waves and patterning in developmental biology: vertebrate segmentation and feather bud formation as case studies

In this article we will discuss the integration of developmental patterning mechanisms with waves of competency that control the ability of a homogeneous field of cells to react to pattern forming cues and generate spatially heterogeneous patterns. We base our discussion around two well known patterning events that take place in the early embryo: somitogenesis and feather bud formation. We outline mathematical models to describe each patterning mechanism, present the results of numerical simulations and discuss the validity of each model in relation to our example patterning processes

A mathematical investigation of a clock and wavefront model for somitogenesis

Abstract Somites are transient blocks of cells that form sequentially along the antero-posterior axis of vertebrate embryos. They give rise to the vertebrae, ribs and other associated features of the trunk. In this work we develop and analyse a mathematical formulation of a version of the Clock and Wavefront model for somite formation, where the clock controls when the boundaries of the somites form and the wavefront determines where they form. Our analysis indicates that this interaction between a segmentation clock and a wavefront can explain the periodic pattern of somites observed in normal embryos. We can also show that a simplification of the model provides a mechanism for predicting the anomalies resulting from perturbation of the wavefront

Formation of vertebral precursors: Past models and future predictions

Disruption of normal vertebral development results from abnormal formation and segmentation of the vertebral precursors, called somites. Somitogenesis, the sequential formation of a periodic pattern along the antero-posterior axis of vertebrate embryos, is one of the most obvious examples of the segmental patterning processes that take place during embryogenesis and also one of the major unresolved events in developmental biology. We review the most popular models of somite formation: Cooke and Zeeman's clock and wavefront model, Meinhardt's reaction-diffusion model and the cell cycle model of Stern and co-workers, and discuss the consistency of each in the light of recent experimental findings concerning FGF-8 signalling in the presomitic mesoderm (PSM). We present an extension of the cell cycle model to take account of this new experimental evidence, which shows the existence of a determination front whose position in the PSM is controlled by FGF-8 signalling, and which controls the ability of cells to become competent to segment. We conclude that it is, at this stage, perhaps erroneous to favour one of these models over the others

Formation of vertebral precursors: Past models and future predictions

Disruption of normal vertebral development results from abnormal formation and segmentation of the vertebral precursors, called somites. Somitogenesis, the sequential formation of a periodic pattern along the antero-posterior axis of vertebrate embryos, is one of the most obvious examples of the segmental patterning processes that take place during embryogenesis and also one of the major unresolved events in developmental biology. We review the most popular models of somite formation: Cooke and Zeeman's clock and wavefront model, Meinhardt's reaction-diffusion model and the cell cycle model of Stern and co-workers, and discuss the consistency of each in the light of recent experimental findings concerning FGF-8 signalling in the presomitic mesoderm (PSM). We present an extension of the cell cycle model to take account of this new experimental evidence, which shows the existence of a determination front whose position in the PSM is controlled by FGF-8 signalling, and which controls the ability of cells to become competent to segment. We conclude that it is, at this stage, perhaps erroneous to favour one of these models over the others

A mathematical basis for the clock and wavefront model for somitogenesis

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A mathematical formulation for the cell-cycle model in somitogenesis: analysis, parameter constraints and numerical solutions

In this work we present an analysis, supported by numerical simulations, of the formulation of the cell-cycle model for somitogenesis proposed in Collier et al.(J. Theor. Biol. 207 (2000), 305–316). The analysis indicates that by introducing appropriate parameter constraints on model parameters the cell-cycle mechanism can indeed give rise to the periodic pattern of somites observed in normal embryos. The analysis also provides a greater understanding of the signalling process controlling somite formation and allows us to understand which parameters influence somite length

Symmetries leading to inflation

We present here the general transformation that leaves unchanged the form of the field equations for perfect fluid Friedmann--Robertson--Walker and Bianchi V cosmologies. The symmetries found can be used as algorithms for generating new cosmological models from existing ones. A particular case of the general transformation is used to illustrate the crucial role played by the number of scalar fields in the occurrence of inflation. Related to this, we also study the existence and stability of Bianchi V power law solutions.Comment: 16 pages, uses RevTeX 4, to appear in Phys. Rev.

Stabilisation of an optical transition energy via nuclear Zeno dynamics in quantum dot-cavity systems

We investigate the effect of nuclear spins on the phase shift and polarisation rotation of photons scattered off a quantum dot-cavity system. We show that as the phase shift depends strongly on the resonance energy of an electronic transition in the quantum dot, it can provide a sensitive probe of the quantum state of nuclear spins that broaden this transition energy. By including the electron-nuclear spin coupling at a Hamiltonian level within an extended input-output formalism, we show how a photon scattering event acts as a nuclear spin measurement, which when rapidly applied leads to an inhibition of the nuclear spin dynamics via the quantum Zeno effect, and a corresponding stabilisation of the optical resonance. We show how such an effect manifests in the intensity autocorrelation $g^{(2)}(\tau)$ of scattered photons, whose long-time bunching behaviour changes from quadratic decay for low photon scattering rates (weak laser intensities), to ever slower exponential decay for increasing laser intensities as optical measurements impede the nuclear spin evolution.Comment: 8 pages, 3 figure

The Properties and Gaseous Environments of Powerful Classical Double Radio Galaxies

The properties of a sample of 31 very powerful classical double radio galaxies with redshifts between zero and 1.8 are studied. The source velocities, beam powers, ambient gas densities, total lifetimes, and total outflow energies are presented and discussed. The rate of growth of each side of each source were obtained using a spectral aging analysis. The beam power and ambient gas density were obtained by applying the strong shock jump conditions to the ends of each side of the source. The total outflow lifetime was obtained by applying the power-law relationship between the beam power and the total source lifetime derived elsewhere for sources of this type, and the total outflow energy was obtained by combining the beam power and the total source lifetime. Composite profiles were constructed by combining results obtained from each side of each source. The composite profiles indicate that the ambient gas density falls with distance from the central engine. The source velocities, beam powers, total lifetimes, and total energies seem to be independent of radio source size. This is consistent with the standard model in which each source grows at a roughly constant rate during which time the central engine puts out a roughly constant beam power. The fact that the total source lifetimes and energies are independent of radio source size indicates that the sources are being sampled at random times during their lifetimes.Comment: 7 pages, 5 figures, to appear in "Extragalactic Jets: Theory and Observation from Radio to Gamma Ray", eds. T. A. Rector and D. S. De Young, ASP conference series, Replaced version has minor textual correction