Late Archaic Cultures of the Middle Rio Grande Valley, New Mexico: A Study of the Process of Culture Change

The course of cultural development is examined in the late archaic cultures of the middle Rio Grande valley. New Mexico. Th1s course ls viewed as a process of culture change responding to the impetus from cultural and extra-cultural factors. Change in cultural patterns accessible through the archaeological record, including both economic and social patterns, is delineated; and an attempt is made to explicate this change 1n terms of cultural adaptation. Ecological change 1s recognized as a major factor influencing culture change at the archaic level of development. but other factors are considered. Results of an intensive archaeological survey and subsequent excavation of eight archaic sites, including Boca Negra Cave, on the mesa northwest of the city of Albuquerque are presented. Data from both excavated and unexcavated sites are used to define two newly discovered cultures. the Rio Rancho and Alameda Phases. local manifestations of Basketmaker II and early Basketmaker III cultures respectively. The development of lithic and ceramic techniques, dwelling construction, artifact assemblages, and artifact form and usage is traced through these cultures in detail. Archaeological data and analysis are supplemented by palynological, biological, botanical, and radiocarbon studies contributed by experts in these fields. Late archaic cultural development in the area is seen as resulting primarily from adaptation to oltlang1ng ecological conditions abetted by influxes of southern people and traits. In addition to the development of material traits, subsistence patterns, such as the decreasing importance of hunting and the increasing dependence on maize horticulture, are shown to be part of this adaptation. The apparent stability of social patterns, as indicated by residence group size and the level of group integration, contrasts markedly with the changing economic patterns. Only at the end of the archaic period, when the mesa was abandoned by the form native cultures for the nearby valley, again probably because of the strain placed on economic patterns by ecological change, did changes occur ln these social patterns

Mechanical Properties of Nonwoven Reinforced Thermoplastic Polyurethane Composites

Reinforcement of flexible fibre reinforced plastic (FRP) composites with standard textile fibres is a potential low cost solution to less critical loading applications. The mechanical behaviour of FRPs based on mechanically bonded nonwoven preforms composed of either low or high modulus fibres in a thermoplastic polyurethane (TPU) matrix were compared following compression moulding. Nonwoven preform fibre compositions were selected from lyocell, polyethylene terephthalate (PET), polyamide (PA) as well as para-aramid fibres (polyphenylene terephthalamide; PPTA). Reinforcement with standard fibres manifold improved the tensile modulus and strength of the reinforced composites and the relationship between fibre, fabric and composite’s mechanical properties was studied. The linear density of fibres and the punch density, a key process variable used to consolidate the nonwoven preform, were varied to study the influence on resulting FRP mechanical properties. In summary, increasing the strength and degree of consolidation of nonwoven preforms did not translate to an increase in the strength of resulting fibre reinforced TPU-composites. The TPU composite strength was mainly dependent upon constituent fibre stress-strain behaviour and fibre segment orientation distribution

Cost-effective manufacturing process for the development of automotive from energy efficient composite materials and sandwich structures

The advanced composite materials are increasingly being used in the automotives for their ultralight physical properties and super strong mechanical properties. This research examines the cost-effective single-step liquid resin infusion manufacturing process for developing all composite car body as the generally used sheet molding compound manufacturing process is highly capital intensive. Three different scaled down models of the Eco car were developed focusing on minimal weight and air drag coupled with aesthetics. Structural design and analysis was carried out using the Pro/E and Ansys tools. The Pro-E model was scaled up to generate computer-aided drafting drawings for tool development. Different stations were marked on the model and sliced virtually for development of pattern. Moreover, the mold was manufactured from carbon and glass/polyester composites for prototype manufacturing of the car body. This involved manual placement of desired number of carbon layers as preform on female side of the mold. The vacuum sucked the resin through a number of carefully selected entry ports which ensured effective resin distribution and impregnation. Polycarbonate wind shield was thermoformed in the convection oven according to streamlined geometry of car body and hinged. The car body was integrated with the compatible floor panels and accessories. The crumble zone shock absorber in the bumper was manufactured using successive layers of nomax honeycomb and polyvinyl chloride rigid foam to dampen the accidental shock. The car performed remarkably well in the Eco marathon race held at Malaysia, 35:97–104, 2014. POLYM. COMPOS., 2013. © 2013 Society of Plastics Engineer

Modelling electricity consumption in office buildings: an agent based approach

In this paper, we develop an agent-based model which integrates four important elements, i.e. organisational energy management policies/regulations, energy management technologies, electric appliances and equipment, and human behaviour, to simulate the electricity consumption in office buildings. Based on a case study, we use this model to test the effectiveness of different electricity management strategies, and solve practical office electricity consumption problems. This paper theoretically contributes to an integration of the four elements involved in the complex organisational issue of office electricity consumption, and practically contributes to an application of an agent-based approach for office building electricity consumption study

Genome-wide association study of survival from sepsis due to pneumonia: an observational cohort study

BACKGROUND: Sepsis continues to be a major cause of death, disability, and health-care expenditure worldwide. Despite evidence suggesting that host genetics can influence sepsis outcomes, no specific loci have yet been convincingly replicated. The aim of this study was to identify genetic variants that influence sepsis survival. METHODS: We did a genome-wide association study in three independent cohorts of white adult patients admitted to intensive care units with sepsis, severe sepsis, or septic shock (as defined by the International Consensus Criteria) due to pneumonia or intra-abdominal infection (cohorts 1-3, n=2534 patients). The primary outcome was 28 day survival. Results for the cohort of patients with sepsis due to pneumonia were combined in a meta-analysis of 1553 patients from all three cohorts, of whom 359 died within 28 days of admission to the intensive-care unit. The most significantly associated single nucleotide polymorphisms (SNPs) were genotyped in a further 538 white patients with sepsis due to pneumonia (cohort 4), of whom 106 died. FINDINGS: In the genome-wide meta-analysis of three independent pneumonia cohorts (cohorts 1-3), common variants in the FER gene were strongly associated with survival (p=9·7 × 10(-8)). Further genotyping of the top associated SNP (rs4957796) in the additional cohort (cohort 4) resulted in a combined p value of 5·6 × 10(-8) (odds ratio 0·56, 95% CI 0·45-0·69). In a time-to-event analysis, each allele reduced the mortality over 28 days by 44% (hazard ratio for death 0·56, 95% CI 0·45-0·69; likelihood ratio test p=3·4 × 10(-9), after adjustment for age and stratification by cohort). Mortality was 9·5% in patients carrying the CC genotype, 15·2% in those carrying the TC genotype, and 25·3% in those carrying the TT genotype. No significant genetic associations were identified when patients with sepsis due to pneumonia and intra-abdominal infection were combined. INTERPRETATION: We have identified common variants in the FER gene that associate with a reduced risk of death from sepsis due to pneumonia. The FER gene and associated molecular pathways are potential novel targets for therapy or prevention and candidates for the development of biomarkers for risk stratification. FUNDING: European Commission and the Wellcome Trust

MicroRNAs in skeletal muscle: their role and regulation in development, disease and function

Maintaining skeletal muscle function throughout the lifespan is a prerequisite for good health and independent living. For skeletal muscle to consistently function at optimal levels, the efficient activation of processes that regulate muscle development, growth, regeneration and metabolism is required. Numerous conditions including neuromuscular disorders, physical inactivity, chronic disease and ageing are associated with perturbations in skeletal muscle function. A loss or reduction in skeletal muscle function often leads to increased morbidity and mortality either directly, or indirectly, via the development of secondary diseases such as diabetes, obesity, cardiovascular and respiratory disease. Identifying mechanisms which influence the processes regulating skeletal muscle function is a key priority. The discovery of microRNAs (miRNAs) provides a new avenue that will extend our knowledge of factors controlling skeletal muscle function. miRNAs may also improve our understanding and application of current therapeutic approaches as well as enable the identification of new therapeutic strategies and targets aimed at maintaining and/or improving skeletal muscle health. This review brings together the latest developments in skeletal muscle miRNA biology and focuses on their role and regulation under physiological and patho-physiological conditions with an emphasis on: myogenesis, hypertrophy, atrophy and regeneration; exercise and nutrition; muscle disease, ageing, diabetes and obesity

Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine

[This corrects the article DOI: 10.1186/s13054-016-1208-6.]