Formal total synthesis of (±)-conduramine E utilising the Bryce-Smith-Gilbert photoamination reaction

Utilising a Bryce-Smith-Gilbert photoamination of benzene as a key step, a synthesis of ()-conduramine E was carried out. A highly regioselective dihydroxylation of a cyclic diene was effected utilising Sharpless AD-mix-b

Candidates for asteroid dust trails

The contribution of different sources to the circumsolar dust cloud (known as the zodiacal cloud) can be deduced from diagnostic observations. We used the Spitzer Space Telescope to observe the diffuse thermal emission of the zodiacal cloud near the ecliptic. Several structures were identified in these observations, including previously known asteroid dust bands, which are thought to have been produced by recent asteroid collisions, and cometary trails. Interestingly, two of the detected dust trails, denoted t1 and t2 here, cannot be linked to any known comet. Trails t1 and t2 represent a much larger integrated brightness than all known cometary trails combined and may therefore be major contributors to the circumsolar dust cloud. We used our Spitzer observations to determine the orbits of these trails and were able to link them to two ("orphan" or type II) trails that were discovered by the Infrared Astronomical Satellite (IRAS) in 1983. The orbits of trails t1 and t2 that we determined by combining the Spitzer and IRAS data have semimajor axes, eccentricities, and inclinations like those of the main-belt asteroids. We therefore propose that trails t1 and t2 were produced by very recent (<~100 kyr old) collisional breakups of small, <~10 km diameter main-belt asteroids

Raising Cash Under Duress And The Role Of Cash Value Life Insurance: An Educational Example

Consumers face hard choices when they need cash quickly. Hard choices can lead to emotional or economically unsound decisions. Traditional classroom discussions of raising funds to pay for expenses usually focus on generating income, borrowing, or the sale of real and financial assets, if hardship is discussed at all. However, many families have additional “non-traditional” sources of cash. This article examines the use of life insurance surrenders and policy loans as a source of funds for both routine funding needs as well as a source of emergency financing. The article concludes with a review of the economic considerations of life insurance for Insurance and Financial Planning educators and students

Mycobacterium and the coat of many lipids

Pathogenic Mycobacterium reside inside vacuoles in their host macrophages. These vacuoles fail to fuse with lysosomes yet interact with early endosomes. Glycoconjugates released by the intracellular bacilli traffic through the host cell and are released through exocytosis. These molecules represent both antigens for immune recognition and modulators of immune function. The molecules play key roles in the induction and maintenance of the granuloma, a tissue response that limits bacterial spread yet ensures persistence of the infection