AMAZÔNIA E A CARREIRA DAS ÍNDIAS: navegação para o norte da América portuguesa na época da Monarquia Hispânica

The old State of Maranhão and Pará Grão, now equivalent to the current states of the Brazilian Amazon, did not belong to the shipping lanes to the State of Brazil. Throughout the first half of the seventeenth century the Portuguese who inhabited that region raised participate in the Carrera de Indias leveraging the ease of navigation to the Viceroyalty of Peru and the Caribbean. This article aims to analyze the reaction of the Portuguese border areas for the integration of Portugal in the Spanish Monarchy (1580-1640). For this work, we use sources on the various proposals of Portuguese participation in the breadcrumb Spanish-Peruvian different files found today in Portugal, Brazil and Spain.El antiguo Estado de Maranhão y Grão Pará, hoy equivalente a los actuales estados de la Amazonia brasileña, no pertenecía a las rutas de navegación hacia el Estado de Brasil. Durante la primera mitad del siglo XVII los portugueses que habitaban esa región se plantearon participar en la Carrera de Indias aprovechando la facilidad de navegación hacia el Virreinato del Perú y el Caribe. Este artículo tiene como objetivo analizar la reacción de los portugueses de las zonas de frontera respecto a la integración de Portugal en la Monarquía Hispánica (1580-1640). Para este trabajo, utilizamos fuentes sobre las diversas propuestas de participación portuguesa en la ruta de navegación hispano-peruana encontradas hoy en diferentes archivos portugueses, brasileños y españoles. [pt] O antigo Estado do Maranhão e Grão-Pará, hoje equivalente aos atuais estados da Amazônia brasileira, não pertencia às rotas de navegação para o Estado do Brasil. Durante a primeira metade do século XVII, os portugueses que habitavam essa região planejaram participar da Carreira das Índias aproveitando a facilidade de navegação até o Vice-Reinado do Peru e para o Caribe. Este artigo tem como objetivo analisar a reação dos portugueses das zonas de fronteira com relação à integração de Portugal à Monarquia Hispânica (1580- 1640). Para este trabalho foram utilizadas fontes sobre as diversas propostas de participação portuguesa na rota de navegação hispano-peruana, disponíveis hoje em diferentes arquivos portugueses, brasileiros e espanhóis

Sustainability appraisal: Jack of all trades, master of none?

Sustainable development is a commonly quoted goal for decision making and supports a large number of other discourses. Sustainability appraisal has a stated goal of supporting decision making for sustainable development. We suggest that the inherent flexibility of sustainability appraisal facilitates outcomes that often do not adhere to the three goals enshrined in most definitions of sustainable development: economic growth, environmental protection and enhancement, and the wellbeing of the human population. Current practice is for sustainable development to be disenfranchised through the interpretation of sustainability, whereby the best alternative is good enough even when unsustainable. Practitioners must carefully and transparently review the frameworks applied during sustainability appraisal to ensure that outcomes will meet the three goals, rather than focusing on a discourse that emphasises one or more goals at the expense of the other(s)

Neural modulation of directed forgetting by valence and arousal: an event-related potential study

Intentional forgetting benefits memory by removing no longer needed information and promoting processing of more relevant materials. This study sought to understand how the behavioural and neurophysiological representation of intentional forgetting would be impacted by emotion. We took a novel approach by examining the unique contribution of both valence and arousal on emotional directed forgetting. Participants completed an item directed forgetting task for positive, negative, and neutral words at high and lower levels of arousal while brain activity was recorded using electroencephalography (EEG). Behaviourally, recognition of to-be-remembered (TBR) and to-be-forgotten (TBF) items varied as a function of valence and arousal with reduced directed forgetting for high arousing negative and neutral words. In the brain, patterns of frontal and posterior activation in response to TBF and TBR cues respectively replicated prior EEG evidence to support involvement of inhibitory and selective rehearsal mechanisms in item directed forgetting. Interestingly, emotion only impacted cue-related posterior activity, which varied depending on specific interactions between valence and arousal. Together, results suggest that the brain handles valence and arousal differently and highlights the importance of considering in a collective manner the multidimensional nature of emotion in experimentation

A national facility for biological cryo-electron microscopy

Three-dimensional electron microscopy is an enormously powerful tool for structural biologists. It is now able to provide an understanding of the molecular machinery of cells, disease processes and the actions of pathogenic organisms from atomic detail through to the cellular context. However, cutting-edge research in this field requires very substantial resources for equipment, infrastructure and expertise. Here, a brief overview is provided of the plans for a UK national three-dimensional electron-microscopy facility for integrated structural biology to enable internationally leading research on the machinery of life. State-of-the-art equipment operated with expert support will be provided, optimized for both atomic-level single-particle analysis of purified macromolecules and complexes and for tomography of cell sections. The access to and organization of the facility will be modelled on the highly successful macromolecular crystallography (MX) synchrotron beamlines, and will be embedded at the Diamond Light Source, facilitating the development of user-friendly workflows providing near-real-time experimental feedback

Quantitative imaging of concentrated suspensions under flow

We review recent advances in imaging the flow of concentrated suspensions, focussing on the use of confocal microscopy to obtain time-resolved information on the single-particle level in these systems. After motivating the need for quantitative (confocal) imaging in suspension rheology, we briefly describe the particles, sample environments, microscopy tools and analysis algorithms needed to perform this kind of experiments. The second part of the review focusses on microscopic aspects of the flow of concentrated model hard-sphere-like suspensions, and the relation to non-linear rheological phenomena such as yielding, shear localization, wall slip and shear-induced ordering. Both Brownian and non-Brownian systems will be described. We show how quantitative imaging can improve our understanding of the connection between microscopic dynamics and bulk flow.Comment: Review on imaging hard-sphere suspensions, incl summary of methodology. Submitted for special volume 'High Solid Dispersions' ed. M. Cloitre, Vol. xx of 'Advances and Polymer Science' (Springer, Berlin, 2009); 22 pages, 16 fig

Integrated ecological monitoring in Wales: the Glastir Monitoring and Evaluation Programme field survey

The Glastir Monitoring and Evaluation Programme (GMEP) ran from 2013 until 2016 and was probably the most comprehensive programme of ecological study ever undertaken at a national scale in Wales. The programme aimed to (1) set up an evaluation of the environmental effects of the Glastir agri-environment scheme and (2) quantify environmental status and trends across the wider countryside of Wales. The focus was on outcomes for climate change mitigation, biodiversity, soil and water quality, woodland expansion, and cultural landscapes. As such, GMEP included a large field-survey component, collecting data on a range of elements including vegetation, land cover and use, soils, freshwaters, birds, and insect pollinators from up to three-hundred 1 km survey squares throughout Wales. The field survey capitalised upon the UK Centre for Ecology & Hydrology (UKCEH) Countryside Survey of Great Britain, which has provided an extensive set of repeated, standardised ecological measurements since 1978. The design of both GMEP and the UKCEH Countryside Survey involved stratified-random sampling of squares from a 1 km grid, ensuring proportional representation from land classes with distinct climate, geology and physical geography. Data were collected from different land cover types and landscape features by trained professional surveyors, following standardised and published protocols. Thus, GMEP was designed so that surveys could be repeated at regular intervals to monitor the Welsh environment, including the impacts of agri-environment interventions. One such repeat survey is scheduled for 2021 under the Environment and Rural Affairs Monitoring & Modelling Programme (ERAMMP). Data from GMEP have been used to address many applied policy questions, but there is major potential for further analyses. The precise locations of data collection are not publicly available, largely for reasons of landowner confidentiality. However, the wide variety of available datasets can be (1) analysed at coarse spatial resolutions and (2) linked to each other based on square-level and plot-level identifiers, allowing exploration of relationships, trade-offs and synergies. This paper describes the key sets of raw data arising from the field survey at co-located sites (2013 to 2016). Data from each of these survey elements are available with the following digital object identifiers (DOIs): Landscape features (Maskell et al., 2020a–c), https://doi.org/10.5285/82c63533-529e-47b9-8e78-51b27028cc7f, https://doi.org/10.5285/9f8d9cc6-b552-4c8b-af09-e92743cdd3de, https://doi.org/10.5285/f481c6bf-5774-4df8-8776-c4d7bf059d40; Vegetation plots (Smart et al., 2020), https://doi.org/10.5285/71d3619c-4439-4c9e-84dc-3ca873d7f5cc; Topsoil physico-chemical properties (Robinson et al., 2019), https://doi.org/10.5285/0fa51dc6-1537-4ad6-9d06-e476c137ed09; Topsoil meso-fauna (Keith et al., 2019), https://doi.org/10.5285/1c5cf317-2f03-4fef-b060-9eccbb4d9c21; Topsoil particle size distribution (Lebron et al., 2020), https://doi.org/10.5285/d6c3cc3c-a7b7-48b2-9e61-d07454639656; Headwater stream quality metrics (Scarlett et al., 2020a), https://doi.org/10.5285/e305fa80-3d38-4576-beef-f6546fad5d45; Pond quality metrics (Scarlett et al., 2020b), https://doi.org/10.5285/687b38d3-2278-41a0-9317-2c7595d6b882; Insect pollinator and flower data (Botham et al., 2020), https://doi.org/10.5285/3c8f4e46-bf6c-4ea1-9340-571fede26ee8; and Bird counts (Siriwardena et al., 2020), https://doi.org/10.5285/31da0a94-62be-47b3-b76e-4bdef3037360

The Australasian Resuscitation In Sepsis Evaluation : fluids or vasopressors in emergency department sepsis (ARISE FLUIDS), a multi-centre observational study describing current practice in Australia and New Zealand

Objectives: To describe haemodynamic resuscitation practices in ED patients with suspected sepsis and hypotension. Methods: This was a prospective, multicentre, observational study conducted in 70 hospitals in Australia and New Zealand between September 2018 and January 2019. Consecutive adults presenting to the ED during a 30-day period at each site, with suspected sepsis and hypotension (systolic blood pressure <100 mmHg) despite at least 1000 mL fluid resuscitation, were eligible. Data included baseline demographics, clinical and laboratory variables and intravenous fluid volume administered, vasopressor administration at baseline and 6- and 24-h post-enrolment, time to antimicrobial administration, intensive care admission, organ support and in-hospital mortality. Results: A total of 4477 patients were screened and 591 were included with a mean (standard deviation) age of 62 (19) years, Acute Physiology and Chronic Health Evaluation II score 15.2 (6.6) and a median (interquartile range) systolic blood pressure of 94 mmHg (87–100). Median time to first intravenous antimicrobials was 77 min (42–148). A vasopressor infusion was commenced within 24 h in 177 (30.2%) patients, with noradrenaline the most frequently used (n = 138, 78%). A median of 2000 mL (1500–3000) of intravenous fluids was administered prior to commencing vasopressors. The total volume of fluid administered from pre-enrolment to 24 h was 4200 mL (3000–5661), with a range from 1000 to 12 200 mL. Two hundred and eighteen patients (37.1%) were admitted to an intensive care unit. Overall in-hospital mortality was 6.2% (95% confidence interval 4.4–8.5%). Conclusion: Current resuscitation practice in patients with sepsis and hypotension varies widely and occupies the spectrum between a restricted volume/earlier vasopressor and liberal fluid/later vasopressor strategy

On Spanish Dvandva and its restrictions

As noted by Bauer, real dvandva compounds –that is, coordinative compounds that properly express the aggregation of two different entities, not the intersection of properties in one entity– are extremely rare in English or Spanish. This article explores the empirical domain of dvandva compounding in Spanish, and notes that they are productive when not used as heads within their phrases. We propose that the explanation for this is that Spanish can only productively build dvandva compounds using flat structures without internal hierarchy. This causes the compound to look externally for a head noun that defines the interpretation of the relation established between the two members of the dvandva. The proposal also explains why proper names is preferred in dvandva compounding, given that they do not denote properties

Hospitais: espaços de cura e lugares de memória da saúde

O presente artigo pretende analisar o Hospital Gaffrée e Guinle, construído na década de 1920, na cidade do Rio de Janeiro, em um processo de tomada de controle, pela administração pública, da gestão da assistência hospitalar na capital federal. Esse hospital representa o encontro da filantropia com um projeto de saúde pública posto em prática no Distrito Federal à mesma época. A instituição sintetiza também o desenvolvimento da medicina e sua tradução na arquitetura hospitalar, bem como a efervescência intelectual do período, mais especificamente das idéias nacionalistas, interpretadas tanto na escolha do estilo arquitetônico - o neocolonial - quanto na questão da salvação da raça através do combate e controle da sífilis.This paper analyzes the Gaffrée & Guinle Hospital, built in Rio de Janeiro during the 1920s as the result of a process whereby the government took over the management of hospital care in the federal capital. The hospital is the point of convergence between philanthropy and a public healthcare project implemented in the Federal District at that time. It also synthesizes the development of medicine and how the latter translates into hospital architecture, as well as the intellectual effervescence at the time, more specifically the nationalist ideas which can be identified both in the choice of architectural style - namely the neocolonial - and in the theme of salvation of a race through the combat and control of syphilis