Non-Ergodic Behaviour of the k-Body Embedded Gaussian Random Ensembles for Bosons

We investigate the shape of the spectrum and the spectral fluctuations of the $k$-body Embedded Gaussian Ensemble for Bosons in the dense limit, where the number of Bosons $m \to \infty$ while both $k$, the rank of the interaction, and $l$, the number of single-particle states, are kept fixed. We show that the relative fluctuations of the low spectral moments do not vanish in this limit, proving that the ensemble is non-ergodic. Numerical simulations yield spectra which display a strong tendency towards picket-fence type. The wave functions also deviate from canonical random-matrix behaviourComment: 7 pages, 5 figures, uses epl.cls (included

Clinical Profile of Eprosartan: A Different Angiotensin II Receptor Blocker

Rationale. The goal of antihypertensive treatment is to reduce risk of cardiovascular morbidity and mortality. Apart from blood pressure lowering per se, also reducing the activities of the renin-angiotensin system and sympathetic nervous system appears to be important. Angiotensin II receptor blocker drugs (ARBs) have provided a useful class of anti-hypertensive drugs. Eprosartan is a relatively new ARB which is chemically distinct (non-biphenyl, non-tetrazole) from all other ARBs (biphenyl tetrazoles). An analysis has been made on available experimental and clinical data on eprosartan which not only is an effective and well tolerated antihypertensive agent, but also lowers the activities of the renin-angiotensin system and sympathetic nervous system. Experimental and pharmacokinetic studies on eprosartan have shown differences with the other ARBs. The distinct properties of this non-biphenyl, non-tetrazole ARB might be relevant in the effort to reduce cardiovascular risk, also beyond its blood pressure lowering capacity

A Fast Converging Fractionally Spaced Equaliser

We present subband adaptive structures that can counteract the slow convergence which is imposed on the feed-forward part of a fractionally spaced equaliser by the spectral dynamics of the oversampled channel output. While the prewhitening of the subband approach is therefore beneficial to the feed-forward part, additionally operating the feedback part in subbands results in a more balanced and faster convergence, which is demonstrated in simulations

A Performance Comparison of Fullband and Different Subband Equalisers

We present two different fractionally spaced (FS) equalisers based on subband methods, with the aim of reducing the computational complexity and increasing the convergence rate of a standard fullband FS equaliser. This is achieved by operating in decimated subbands at a considerably lower update rate and by exploiting the prewhitening effect that a filter bank has on the considerable spectral dynamics of a signal received through a severely distorting channel. The two presented subband structures differ in their level of realising the feedforward and feedback part of the equaliser in the subband domain, with distinct impacts on the updating. Simulation results pinpoint the faster convergence at lower cost for the proposed subband equalisers

The Impact of Medicare's Prospective Payment System on Psychiatric Patients Treated in Scatterbeds

Medicare's Prospective Payment System (PPS) for hospitals was phased-in during the 1884 Federal Fiscal Year. While many providers of psychiatric inpatient care were exempted from PPS patients treated in general hospital beds outside of psychiatric units (scatterbeds) were not. This allows for an initial assessment of the impact of PPS on psychiatric patients. We use a single equation model of hospital length of stay to estimate the impact of PPS. We allow for the possibility of both anticipating behavior and slow adjustment to the new payment scheme. The results indicate a substantial response to PPS over the first year of implementation. The estimated response includes sizable anticipatory and slow adjustment components. The findings suggest that policy discussions may be weighted too heavily in the direction of concern over hospital financial status given the ability of hospitals to change their behavior.

Neutron optical beam splitter from holographically structured nanoparticle-polymer composites

We report a breakthrough in the search for versatile diffractive elements for cold neutrons. Nanoparticles are spatially arranged by holographical means in a photopolymer. These grating structures show remarkably efficient diffraction of cold neutrons up to about 50% for effective thicknesses of only 200 micron. They open up a profound perspective for next generation neutron-optical devices with the capability to tune or modulate the neutron diffraction efficiency.Comment: 4 pages, 2 figure

Two-step thermochemical solar-to-fuel efficiency computation of strontium and chromium doped lanthanum manganite perovskite oxides using CALPHAD

Reducing greenhouse gas emissions and profiting on novel synthetic fuels to store and buffer energy from renewable sources (such as solar or wind) is a prime strategy to encounter the global energy challenge. Here, two-step thermochemical fuel production is an energy technology utilizing intermittent solar power to convert water and carbon dioxide into syngas, a renewable fuel that can be stored easily and mitigate CO2 emissions. Success of the technology relies on the discovery of materials with a high thermochemical solar-to-fuel efficiency. Perovskites have attracted much attention recently due to impressive fuel productivity[1, 2]. Although a high fuel productivity shows the feasibility of a material, it does not imply that it is the optimum and most efficient material as it depends largely on the operation of the solar-to-fuel reactor [3, 4]. Literature on thermochemical solar-to-fuel efficiency of perovskites is limited and none of the existing studies measures the thermodynamic properties in the entire temperature range relevant for solar-to-fuel production, namely 1000-1800K. In this work, we use oxygen nonstoichiometry from CALPHAD data libraries on A-site doped La1-xSrxMnO3-δ and B-site doped perovskite La0.6Sr0.4Mn1-yCryO3-δ in a relevant temperature range of 1073-1873K to determine the solar thermochemical efficiency. The oxygen nonstoichiometry and thermodynamic properties extracted from CALPHAD libraries are compared to earlier studies of La1-xSrxMnO3-δ for thermochemical fuel production. We discuss diffferences between the earlier extrapolated models and the CALPHAD descriptions on the presented material examples. Specifically, we show thermochemical equilibrium models of fuel productivity supplemented by validations with experimental results on La1-xSrxMnO3-δ in literature. We make predictions on the most efficient material in the composition space La1-xSrxMn1-yCryO3-δ for different conditions. It is shown that the amount of experimental work can be reduced substantially by using the CALPHAD approach and further making predictions for multi-component systems that would be practically unattainable without this method. The solar-to-fuel field will benefit directly from additional thermodynamic data on perovskites in the relevant temperature range. Further, we provide guidelines in terms of key CALPHAD experiments that enables a mapping of the thermodynamic properties of a wide compositional space of perovskites to find materials with a high thermochemical efficiency. 1. McDaniel, A.H., et al., Sr-and Mn-doped LaAlO3−δ for solar thermochemical H2 and CO production. Energy & Environmental Science, 2013. 6(8): p. 2424-2428. 2. Bork, A.H., et al., Perovskite La0.6Sr 0.4Cr1− xCoxO3−δ solid solutions for solar-thermochemical fuel production: strategies to lower the operation temperature. Journal of Materials Chemistry A, 2015. 3(30): p. 15546-15557. 3. Scheffe, J.R., D. Weibel, and A. Steinfeld, Lanthanum–Strontium–Manganese Perovskites as Redox Materials for Solar Thermochemical Splitting of H2O and CO2. Energy & Fuels, 2013. 27(8): p. 4250-4257. 4. Yang, C.-K., et al., Thermodynamic and kinetic assessments of strontium-doped lanthanum manganite perovskites for two-step thermochemical water splitting. Journal of Materials Chemistry A, 2014. 2(33): p. 13612-13623

Das FH-defiziente Nierenzellkarzinom erweitert das Spektrum der papillären Tumoren in der Niere

Fumarate hydratase (FH)-deficient renal cell carcinoma (RCC) is a distinct entity, which shows a biallelic inactivation of the FH gene that consequently leads to FH protein expression and function loss, respectively. This alteration leads to an accumulation of the oncometabolite fumarate in the citrate cycle and various disorders of the cell balance and DNA processing. FH-deficient RCC often shows a morphologically overlapping spectrum with papillary renal cell carcinoma (type 2), whereby a typical mixture of growth patterns including tubulo-cystic, cribriform, and/or solid differentiation can be observed. A characteristic but non-specific morphological feature is prominent eosinophilic, virus-inclusion body-like nucleoli with perinucleolar halos. Tumoral immunohistochemical loss of FH expression supports the diagnosis but may be preserved in rare cases. Most FH-deficient RCCs show very aggressive biological behavior and are often metastasized at the time of diagnosis. The initial description encompassed RCC in association with the hereditary leiomyomatosis and renal cell carcinoma (HLRCC) syndrome, which also includes cutaneous and uterine leiomyomas. However, current data also show an increasing proportion of sporadic cases, so that a distinction (hereditary vs. sporadic) seems appropriate. So far, few but promising data on effective systemic therapeutic options have been reported. In summary, precise diagnosis is of great importance due to the frequent aggressive biological behavior, potential need to deviate from the therapeutic standard, and the possible indicator of a hereditary disease