The importance of melatonin in the regulation of metabolism, eating behavior, sleep, and the prospects for the use of melatonin drugs for obesity treatment

Melatonin is a special hormone that act as an internal synchronizer of circadian rhythms, the organism physiology and behavior to the environmental day and night and seasons of the year. The present urban society and the industrial production processes as organized should be considered, as both depend on the presence of indoor lights during the night and include the profuse use of electronic devices whose screens are rich in blue wavelength light. Light during the night delays the beginning of the secretory episode of melatonin and blunts its peak, causing chronic hypomelatoninemia. Hypomelatonemia, that causes deprivation of sleep and eating behavior disorders, along with low physical activity, can be the reason of the obesity, «non-infectious epidemic of the 21st century». According to this, the use of melatonin drugs for obesity treatment can be effective. Further prospective, controlled, randomized trials in this area are required to confirm this hypothesis

The study of the formation of relations of educational cooperation of younger schoolchildren

Introduction: the need to study the current state of relations of educational cooperation of younger students is determined by the increasing role of communicative universal educational activities in the development of modern society. However,  a number of studies it prove that often the life of a modern school does not provide any opportunities to use the potential resources of such an important component of the development of the student, as educational cooperation. Traditional school due to many restrictions does not always provide the possibility to build a student-centered relationship of educational cooperation in combination with a differentiated approach to younger students. Numerous studies often describe the interaction of students with adults and peers separately, that prevents making unified approaches to the child's socialization.The initial step towards solving this problem should be the complex study of the areas of interaction and diverse study of the formation of relations of educational cooperation of younger schoolchildrenMaterials and Methods: in article the diagnostic program-the complex made of the techniques giving the chance to get the idea of a modern state of development of the relations of educational cooperation in elementary school is declared. They were: a technique with the working title  “ the Carpet”, allowing to establish levels of development of skills of group interaction of younger schoolchildren in the lessons; “Sociometric research”, intended for identification of the social status of the child in children's group; “Self-esteem ladder”, designed to determine the adequacy of children's self-esteem in the sphere of business contacts of the child with classmates.Results: the results of the study of the formation of relations of educational cooperation among younger schoolchildren with peers in a specially created innovative conditions in the context of a given procedure of learning and initiated by the child communication. The idea of teachers about the most important for younger schoolchildren’s psychological conditions of development of relations of educational cooperation is revealed.Discussion and Conclusions: the study suggests that for the effective development of relations of educational cooperation with children it is necessary to create a special innovative learning environment, which provides a high motivational basis for younger students to achieve their goals, initiatives, independence, strengthen their social status in the group of peers, increase self-esteem.</jats:p

INVESTIGATION OF LABOR ACTIVITY MOTIVATION OF OF THE HIGHER EDUCATION TEACHER

Introduction: the need for study of the actual state of professional activity motivation of higher education teachers is determined by the growing social role of university teachers in the development of modern society. However, it is noted in some research papers that currently university teachers are in the most difficult position, which is caused by the decrease of social and public recognition of the value of the profession, the staff deficit, staff aging and turnover. As a special problem, the crisis of motivation and professional identity in the sphere of higher education stands out alongside with the significant complication of the work of teachers of modern higher education. In these conditions, the main task is to develop and implement fundamentally new, effective management policy aimed at attracting, retaining and motivating highly qualified scientific and pedagogical personnel. The starting point for solving this problem should be a diverse study of the motivation of the work of the modern teacher of the university.Materials and Methods: the article presents a set of methods that provide diverse assessment of the current state of motivation of teachers at the university: the questionnaire "Motivation of the professional activity" (K. Zamfir), a questionnaire for identifying factors that stimulate and impede the teaching, development and self-development of teachers (Shamov), a questionnaire to study the motivation of the professional activity of the university teacher (E.G. Gutsu)Results: the results of the pilot study of the motivation of the teachers at the university are presented. The presentation of teachers about the factors that stimulate and impede professional development, the subjective perception by teachers of the changes taking place in higher education is revealed.Discussion and Conclusions: the conducted study suggests that the management of the motivation of the work of teachers with the help of administrative resources does not always lead to the development of labor motivation of university teachers and raise the questions of the need to search for internal reserves for the development of the motivation of the higher education teachers

The state of the alveolar bone tissue depending on the vitality of the tooth pulp according to the saliva indicators of patients with moderate periodontitis

Aim. To evaluate the results of surgical treatment of patients with moderate chronic periodontitis with different dental pulp status by determining sRANKL, OPG and FGF-2 in mixed saliva and dynamic densitotomometry data.Materials and methods. Surgical treatment of 24 patients with moderate chronic periodontitis was performed. Three months before the operation, according to the indications, endodontic treatment of the examined teeth was performed in some patients. Depending on the status of the dental pulp, the patients were divided into two groups: I – patients with vital teeth, II – patients with teeth after endodontic treatment. Before and after surgery, all patients underwent clinical examination, enzyme immunoassay of saliva remodeling markers and optical densitotomometry of periodontal bone to compare the results of treatment. Results. The OHI-S index showed a significant decrease in the mean value by 12 months of observation in both groups, which was statistically significant. Higher indices of the PI index by the end of the observation period were detected in the area of depulpated teeth. An equivalent dynamics of a decrease in the value of periodontal attachment according to the CAL index was revealed in both groups after treatment. The saliva showed an equivalent decrease in sRANKL, an increase in OPG by the end of the observation period, statistically insignificant when compared between groups. FGF-2 remained undetected at any of the observation periods in all groups. Densitotomometry data indicated an increase in the density characteristics of periodontal bone by the end of observations with a stable dependence on lower values in the area of depulpated teeth. Conclusions. In the saliva of patients, the processes of periodontal bone resorption were found to be statistically equivalent in intensity, regardless of the status of the dental pulp. The absence of FGF-2 content in saliva until the end of the observation period should be considered as an indicator of periodontal healing of vital and depulpated teeth by the formation of fibrous connective tissue. Dynamic densitotomometry of alveolar bone tissue revealed statistically significantly lower density characteristics in the area of teeth with a condition after endodontic treatment. </jats:p

Human immunodeficiency virus influence bone tissue

The impact of human immunodeficiency virus (HIV) and antiretroviral therapy upon mineral metabolism and bone mineral density is being studied worldwide. Patients with HIV are a risk group for reduced bone mineral density as these diseases are more common in them than in healthy people. The report presents a review of the literature on the topic. The review consists of several parts, and each of them deals with the effect of HIV and antiretroviral therapy on bony tissue and osteoclastogenesis at different levels: molecular, cellular, tissue, hormonal and various extracellular protein levels. Due to modern diagnostics and treatment, the survival rate of patients with HIV infection has increased significantly. It has led to the problem of developing not only dysimmunity but also age-related diseases. When discussing the problem of bone formation and bone resorption in HIV, the multifactorial nature of these conditions must be considered to further prediction of secondary diseases development to adjust patient's management for hormonal and age-related changes, resource allocation, and educating health professionals in diagnosis and treatment. The review relies on the data from peer-reviewed medical journals, using a bibliographic search method and relevant internet resources, including PubMed.</jats:p

The importance of melatonin in the regulation of metabolism, eating behavior, sleep, and the prospects for the use of melatonin drugs for obesity treatment

Melatonin is a special hormone that act as an internal synchronizer of circadian rhythms, the organism physiology and behavior to the environmental day and night and seasons of the year. The present urban society and the industrial production processes as organized should be considered, as both depend on the presence of indoor lights during the night and include the profuse use of electronic devices whose screens are rich in blue wavelength light. Light during the night delays the beginning of the secretory episode of melatonin and blunts its peak, causing chronic hypomelatoninemia. Hypomelatonemia, that causes deprivation of sleep and eating behavior disorders, along with low physical activity, can be the reason of the obesity, «non-infectious epidemic of the 21st century». According to this, the use of melatonin drugs for obesity treatment can be effective. Further prospective, controlled, randomized trials in this area are required to confirm this hypothesis.</jats:p

Some New Opportunities in the Treatment of Patients with Atherosclerosis

According to our deep conviction, measures to prevent, detect and treat atherosclerosis should be largely reoriented to the preclinical period of the disease and include correction, including non-medication, of metabolic disorders, elimination of other avoidable endogenous and exogenous risk factors for atherosclerosis, and primarily hyperlipidemia.</jats:p