Sketching the Pharisees

This paper explores the Pharisees and their place in Palestinian society, particularly during the first century. Recent scholarly reconstructions are reviewed and compared to the evidence found in the works of Josephus, the New Testament, and rabbinic literature. This paper examines the Pharisees through the eyes of each source and attempts to use each viewpoint to develop a picture of the Pharisaic movement. The evidence proves too ambiguous to clarify the fine details of the movement, and it resists placing them at the top of the Jewish social or religious system. It does, however, suggest that the Pharisees represent a recognizable, well-known, and even celebrated expression of mainline Judaism, and it is possible that the movement\u27s positive reputation offered members special opportunities which lead to a measure of influence in society. This conclusion is useful as a basis for multiple reconstructions, including some of the scholarly reconstructions reviewed in the paper

Sketching the Pharisees

This paper explores the Pharisees and their place in Palestinian society, particularly during the first century. Recent scholarly reconstructions are reviewed and compared to the evidence found in the works of Josephus, the New Testament, and rabbinic literature. This paper examines the Pharisees through the eyes of each source and attempts to use each viewpoint to develop a picture of the Pharisaic movement. The evidence proves too ambiguous to clarify the fine details of the movement, and it resists placing them at the top of the Jewish social or religious system. It does, however, suggest that the Pharisees represent a recognizable, well-known, and even celebrated expression of mainline Judaism, and it is possible that the movement\u27s positive reputation offered members special opportunities which lead to a measure of influence in society. This conclusion is useful as a basis for multiple reconstructions, including some of the scholarly reconstructions reviewed in the paper

NIRS Measurements with Elite Speed Skaters: Comparison Between the Ice Rink and the Laboratory

Wearable, wireless near-infrared (NIR) spectrometers were used to compare changes in on-ice short-track skating race simulations over 1,500 m with a 3-min cycle ergometry test at constant power output (400 W). The subjects were six male elite short-track speed skaters. Both protocols elicited a rapid desaturation (∆TSI%) in the muscle during early stages (initial 20 s); however, asymmetry between right and left legs was seen in ΔTSI% for the skating protocol, but not for cycling. Individual differences between skaters were present in both protocols. Notably, one individual who showed a relatively small TSI% change (-10.7%, group mean = -26.1%) showed a similarly small change during the cycling protocol (-5.8%, group mean = -14.3%). We conclude that NIRS-detected leg asymmetry is due to the specific demands of short-track speed skating. However, heterogeneity between individuals is not specific to the mode of exercise. Whether this is a result of genuine differences in physiology or a reflection of differences in the optical properties of the leg remains to be determined

Analysis of Gap Gene Regulation in a 3D Organism-Scale Model of the Drosophila melanogaster Embryo

The axial bodyplan of Drosophila melanogaster is determined during a process called morphogenesis. Shortly after fertilization, maternal bicoid mRNA is translated into Bicoid (Bcd). This protein establishes a spatially graded morphogen distribution along the anterior-posterior (AP) axis of the embryo. Bcd initiates AP axis determination by triggering expression of gap genes that subsequently regulate each other's expression to form a precisely controlled spatial distribution of gene products. Reaction-diffusion models of gap gene expression on a 1D domain have previously been used to infer complex genetic regulatory network (GRN) interactions by optimizing model parameters with respect to 1D gap gene expression data. Here we construct a finite element reaction-diffusion model with a realistic 3D geometry fit to full 3D gap gene expression data. Though gap gene products exhibit dorsal-ventral asymmetries, we discover that previously inferred gap GRNs yield qualitatively correct AP distributions on the 3D domain only when DV-symmetric initial conditions are employed. Model patterning loses qualitative agreement with experimental data when we incorporate a realistic DV-asymmetric distribution of Bcd. Further, we find that geometry alone is insufficient to account for DV-asymmetries in the final gap gene distribution. Additional GRN optimization confirms that the 3D model remains sensitive to GRN parameter perturbations. Finally, we find that incorporation of 3D data in simulation and optimization does not constrain the search space or improve optimization results

Complication prevalence following use of tutoplast-derived human acellular dermal matrix in prosthetic breast reconstruction: A retrospective review of 203 patients

SummaryUse of human acellular dermal matrix (ADM) during prosthetic breast reconstruction has increased. Several ADM products are available produced by differing manufacturing techniques. It is not known if outcomes vary with different products. This study reports the complication prevalence following use of a tutoplast-derived ADM (T-ADM) in prosthetic breast reconstruction. We performed a retrospective chart review of 203 patients (mean follow-up times 12.2 months) who underwent mastectomy and immediate prosthetic breast reconstruction utilizing T-ADM, recording demographic data, surgical indications and complication (infection, seroma, hematoma, wound healing exceeding three weeks and reconstruction failure). During a four-year period, 348 breast reconstructions were performed Complications occurred in 16.4% of reconstructed breasts. Infection occurred in 6.6% of breast reconstructions (3.7% – major infection, requiring intravenous antibiotics and 2.9% minor infection, requiring oral antibiotics only). Seromas occurred in 3.4% and reconstruction failure occurred in 0.6% of breast reconstructions. Analysis suggested that complication prevalence was significantly higher in patients with a BMI >30 (p = 0.03). The complication profile following T-ADM use is this series is comparable to that reported for with other ADM products. T-ADM appears to be a safe and acceptable option for use in ADM-assisted breast reconstruction

Relation between high-sensitivity C-reactive protein and cardiovascular and renal markers in a middle-income country in the African region.

BACKGROUND: High-sensitivity C-reactive protein (hs-CRP) is associated with several cardiovascular risk factors (CVRF) and with renal function markers. However, these associations have not been examined in populations in the African region. We analyzed the distribution of hs-CRP and the relationship with a broad set of CVRF, renal markers and carotid intima-media thickness (IMT), in the Seychelles (African region). METHODS: We conducted a survey in the population aged 25-64years (n=1255, participation rate: 80.2%). Analyses were restricted to persons of predominantly African descent (n=1011). RESULTS: Mean and median hs-CRP serum concentrations (mg/l) were 3.1 (SD 7.6) and 1.4 (IQR 0.7-2.9) in men and 4.5 (SD 6.7) and 2.2 (IQR 1.0-5.4) in women (p<0.001 for difference between men and women). hs-CRP was significantly associated with several conventional CVRF, and particularly strongly with markers of adiposity. With regards to renal markers, hs-CRP was strongly associated with cystatin C and with microalbuminuria but not with creatinine. hs-CRP was not associated with IMT. CONCLUSIONS: Serum concentration of hs-CRP was significantly associated with sex, several CVRF and selected renal function markers, which extends similar findings in Europe and in North America to a population in the African region. These findings can contribute to guide recommendations for the use of hs-CRP in clinical practice in the region

Primary care interventions and current service innovations in modifying long-term outcomes after stroke: a protocol for a scoping review.

INTRODUCTION: Interventions delivered by primary and/or community care have the potential to reach the majority of stroke survivors and carers and offer ongoing support. However, an integrative account emerging from the reviews of interventions addressing specific long-term outcomes after stroke is lacking. The aims of the proposed scoping review are to provide an overview of: (1) primary care and community healthcare interventions by generalist healthcare professionals to stroke survivors and/or their informal carers to address long-term outcomes after stroke, (2) the scope and characteristics of interventions which were successful in addressing long-term outcomes, and (3) developments in current clinical practice. METHODS AND ANALYSIS: Studies that focused on adult community dwelling stroke survivors and informal carers were included. Academic electronic databases will be searched to identify reviews of randomised controlled trials (RCTs) and controlled trials, trials from the past 5 years; reviews of observational studies. Practice exemplars from grey literature will be identified through advanced Google search. Reports, guidelines and other documents of major health organisations, clinical professional bodies, and stroke charities in the UK and internationally will be included. Two reviewers will independently screen titles, abstracts and full texts for inclusion of published literature. One reviewer will screen search results from the grey literature and identify relevant documents for inclusion. Data synthesis will include analysis of the number, type of studies, year and country of publication, a summary of intervention components/service or practice, outcomes addressed, main results (an indicator of effectiveness) and a description of included interventions. ETHICS AND DISSEMINATION: The review will help identify components of care and care pathways for primary care services for stroke. By comparing the results with stroke survivors' and carers' needs identified in the literature, the review will highlight potential gaps in research and practice relevant to long-term care after stroke.The work on the protocol is the part of the programme of research ‘Developing primary care services for stroke survivors’ funded by the National Institute for Health Research (NIHR)'s Programme Grants for Applied Research Programme (grant reference number PTC-RP-PG-0213-20001).This is the final version of the article. It first appeared from BMJ Publishing Group via https://doi.org/10.1136/bmjopen-2016-01284

Stroke survivors' and informal caregivers' experiences of primary care and community healthcare services - A systematic review and meta-ethnography.

OBJECTIVE: To describe and explain stroke survivors and informal caregivers' experiences of primary care and community healthcare services. To offer potential solutions for how negative experiences could be addressed by healthcare services. DESIGN: Systematic review and meta-ethnography. DATA SOURCES: Medline, CINAHL, Embase and PsycINFO databases (literature searched until May 2015, published studies ranged from 1996 to 2015). ELIGIBILITY CRITERIA: Primary qualitative studies focused on adult community-dwelling stroke survivors' and/or informal caregivers' experiences of primary care and/or community healthcare services. DATA SYNTHESIS: A set of common second order constructs (original authors' interpretations of participants' experiences) were identified across the studies and used to develop a novel integrative account of the data (third order constructs). Study quality was assessed using the Critical Appraisal Skills Programme checklist. Relevance was assessed using Dixon-Woods' criteria. RESULTS: 51 studies (including 168 stroke survivors and 328 caregivers) were synthesised. We developed three inter-dependent third order constructs: (1) marginalisation of stroke survivors and caregivers by healthcare services, (2) passivity versus proactivity in the relationship between health services and the patient/caregiver dyad, and (3) fluidity of stroke related needs for both patient and caregiver. Issues of continuity of care, limitations in access to services and inadequate information provision drove perceptions of marginalisation and passivity of services for both patients and caregivers. Fluidity was apparent through changing information needs and psychological adaptation to living with long-term consequences of stroke. LIMITATIONS: Potential limitations of qualitative research such as limited generalisability and inability to provide firm answers are offset by the consistency of the findings across a range of countries and healthcare systems. CONCLUSIONS: Stroke survivors and caregivers feel abandoned because they have become marginalised by services and they do not have the knowledge or skills to re-engage. This can be addressed by: (1) increasing stroke specific health literacy by targeted and timely information provision, and (2) improving continuity of care between specialist and generalist services. SYSTEMATIC REVIEW REGISTRATION NUMBER: PROSPERO 2015:CRD42015026602

Everything you always wanted to know about dictionaries (but were afraid to ask): A Massive Open Online Course

© Lexicography in Global Contexts. We have created a Massive Open Online Course (MOOC) about dictionaries and dictionary-making, to be hosted by FutureLearn. This paper discusses the design and development of this course, which is pitched at high school and undergraduate level participants as well as language enthusiasts around the world. The MOOC will answer questions such as: how dictionaries are made and how this process has changed over time; what goes into a dictionary and who decides; and what kinds of language evidence underpin the information which dictionaries provide. Participants will be encouraged to compare the quantity and quality of information in different types of dictionary, and will investigate corpus-based and computational lexicographic methods. It will also consider dictionary users' attitudes and common misconceptions, taking into account the requirements and habits of English language learners as well as fluent speakers. By the end of the course, participants will know about some of the latest trends in lexicographic research, the roles of language technology, corpora and crowdsourcing in the dictionary compilation process, the range of possible dictionary entry components, lexicographical choices and computational methods surrounding the selection and ordering of word meanings, and the content and wording of definitions

Humour in Nietzsche's style

Nietzsche's writing style is designed to elicit affective responses in his readers. Humour is one of the most common means by which he attempts to engage his readers' affects. In this article, I explain how and why Nietzsche uses humour to achieve his philosophical ends. The article has three parts. In part 1, I reject interpretations of Nietzsche's humour on which he engages in self‐parody in order to mitigate the charge of decadence or dogmatism by undermining his own philosophical authority. In part 2, I look at how Nietzsche uses humour and laughter as a critical tool in his polemic against traditional morality. I argue that one important way in which Nietzsche uses humour is as a vehicle for enhancing the effectiveness of his ad hominem arguments. In part 3, I show how Nietzsche exploits humour's social dimension in order to find and cultivate what he sees as the right kinds of readers for his works