Triterpenoids and Sterols from the Leaves and Twigs of Melia azedarach

Two new triterpenoids (1 and 2) and a new sterol (3), together with six known constituents (4–9), were isolated from the leaves and twigs of Melia azedarach. Their chemical structures were elucidated on the basis of spectroscopic analysis. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13659-014-0019-1) contains supplementary material, which is available to authorized users

Effect of binocular visual function training on the reconstruction of binocular visual function in postoperative patients with intermittent exotropia

AIM: To explore the effect of binocular visual function training on the reconstruction of binocular visual function and maintaining the stable eye position in postoperative patients with intermittent exotropia. METHODS: A total of 142 patients with intermittent exotropia underwent strabismus surgery in our hospital from January 2010 to December 2015 were enrolled. These patients were divided into two groups according to whether had binocular visual function training after surgery. The treatment group was used the DV-100 system to train the three-level visual function after surgery. For the control group, no intervention was performed after the operation. Respectively analysis the differences of binocular visual function and eye position in the two groups of patients before and 1mo after surgery, 3mo after surgery, 6mo after surgery, and 1a after surgery. RESULTS: The rate of the positive eye position in the treatment group was higher than the control group in the 6mo and 1a after surgery, and statistically significant difference was found(PCONCLUSION: The binocular visual function may have a certain degree of recovery in the patients with intermittent exotropia after surgery to obtain positive eye position. Through the postoperative visual perception learning and binocular visual function training, the binocular visual function can be better and faster recovered and reconstructed so as to obtain stereoscopic vision. It can better stabilize the eye position and help to reduce the rate of the patient's eye position fallback after surgery

Aged Biochar for the Remediation of Heavy Metal Contaminated Soil: Analysis through an Experimental Case the Physicochemical Property Changes of Field Aging Biochar and Its Effects on the Immobilization Mechanism for Heavy Metal

Heavy metal inducing contamination soil has become a serious concern. Contaminated soil can cause physiochemical and biochemical changes into soil and the plants. Thus, the plant growth and the yield were affected. In additionally, that ultimately leads to the problem of food security and human health. In recent years, many kinds of ways were used for the remediation of heavy metal contaminated soil, such as isolation, phytoremediation, immobilization, extraction, and soil washing. As a new carbon-rich material, biochar has been applied to the remediation of heavy metal pollution in soil. As biochar is rich with porous structure, high cation exchange capacity, pH value, and surface function, it has become an adsorbent for soil heavy metal remediation. While, with time, the capacity of biochar to immobilize the heavy metals may be modified as the sorption sites may get occupied with native soil organic matter or competing contaminant, etc. And that the physicochemical properties of biochar changed significantly during field aging. Thus, to clarify the mechanism of field-aged biochar for the remediation of heavy metal contaminated soil, we analysis, through an experimental case, the physicochemical property changes of field-aged biochar and its effects on the immobilization mechanism for heavy metal

Up-regulation of the expression of cocaine and amphetamine-regulated transcript peptide by electroacupuncture in the arcuate nucleus of diet-induced obese rats

Abstract It was reported that acupuncture or electro-acupuncture (EA) is effective in reducing the body weight for obese patients, although the mechanisms remain obscure. In a previous study, we have found that rats fed with high-fat (HIF) diet developed diet-induced obesity (DIO) with a concomitant decrease in the hypothalamic content of the cocaine and amphetamine-regulated transcript (CART) peptide, a peptide with anorexiogenic effect. To assess the central effect of EA on DIO rat, we revealed that EA up-regulated the expression of CART peptide in the arcuate nucleus (ARC) of the DIO rats. After feeding with HIF diet for 14 weeks, the DIO rats received EA stimulation three times per week for 4 weeks. The expression of CART peptide in ARC was measured using immunohistochemistry. The plasma ACTH was measured with ELISA. EA caused a reduction of both body weight and energy intake in DIO rats and increased the expression of CART peptide in ARC. The plasma ACTH was increased in response to restraint stress, but EA produced no further increase in ACTH levels. The results suggest that EA can up-regulate the expression of CART peptide to approach normal level, resulting in an inhibition of food intake and a reduction of body weight in DIO rats. © 2005 Elsevier Ireland Ltd. All rights reserved. Keywords: Electroacupuncture; CART; Body weight; Diet-induced obesity; Arcuate nucleus In humans and animals, a chronic high-fat (HIF) diet without a compensatory increase in energy expenditure leads to the progressive development of obesity E-mail addresses: [email protected], [email protected] (J.-S. Han). 1 Present address: Department of Surgery, Tianjin No. 3 Central Hospital, Tianjin 300170, China. tiveness of acupuncture, and even today, it is not generally regarded as scientifically acceptable. The problem has always been the difficulty to explain the mechanisms behind the effects of acupuncture, and to demonstrate its effects in controlled clinical trials As in much of human obese cases, the rat model of dietinduced obesity (DIO) appears to follow a polygenic mode in inheritance. Hypothalamic neuropeptides play an important role in regulating energy balanc

Hydrogen Sulfide Alleviates Postharvest Senescence of Grape by Modulating the Antioxidant Defenses

Hydrogen sulfide (H2S) has been identified as an important gaseous signal in plants. Here, we investigated the mechanism of H2S in alleviating postharvest senescence and rotting of Kyoho grape. Exogenous application of H2S released from 1.0 mM NaHS remarkably decreased the rotting and threshing rate of grape berries. H2S application also prevented the weight loss in grape clusters and inhibited the decreases in firmness, soluble solids, and titratable acidity in grape pulp during postharvest storage. The data of chlorophyll and carotenoid content suggested the role of H2S in preventing chlorophyll breakdown and carotenoid accumulation in both grape rachis and pulp. In comparison to water control, exogenous H2S application maintained significantly higher levels of ascorbic acid and flavonoid and total phenolics and reducing sugar and soluble protein in grape pulp. Meanwhile, H2S significantly reduced the accumulation of malondialdehyde (MDA), hydrogen peroxide (H2O2), and superoxide anion (O2∙-) in grape pulp. Further investigations showed that H2S enhanced the activities of antioxidant enzymes ascorbate peroxidase (APX) and catalase (CAT) and decreased those of lipoxygenase (LOX) in both grape peels and pulp. In all, we provided strong evidence that H2S effectively alleviated postharvest senescence and rotting of Kyoho grape by modulating antioxidant enzymes and attenuating lipid peroxidation

Clinical characteristics and risk factors in patients with SARS-CoV-2 Omicron variant infection complicated with cardiovascular diseases

ObjectiveTo investigate the clinical characteristics and risk factors of patients with SARS-CoV-2 Omicron variant infection complicated with cardiovascular diseases.MethodsA retrospective analysis of general clinical data was conducted on patients with SARS-CoV-2 omicron infection complicated with hypertension, coronary heart disease, and heart failure admitted to one hospital in Guangdong Province from December 1, 2022, to February 28, 2023. Clinical symptoms, laboratory tests, imaging examinations, treatment, and clinical outcomes were collected. Multivariate logistic regression analysis was used to analyze the risk factors for mortality in patients with SARS-CoV-2 Omicron variant infection complicated with cardiovascular diseases. ROC curves were drawn to evaluate the predictive value of CRP, D-dimer, and CK-MB in predicting the risk of death.ResultsA total of 364 confirmed cases were included, divided into the asymptomatic group, mild to moderate group, and severe to critically ill group based on the symptoms of COVID-19. There were 216 males (59.34%) and 148 females (40.66%), with a median age of 75 years. The differences between the three groups in terms of sex and age were statistically significant (p < 0.05). The top three underlying diseases were hypertension (288 cases, 79.12%), coronary heart disease (100 cases, 27.47%), and diabetes (84 cases, 23.08%). The differences in unvaccinated and triple-vaccinated patients among the three groups were statistically significant (p < 0.05). The common respiratory symptoms were cough in 237 cases (65.11%) and sputum production in 199 cases (54.67%). In terms of laboratory tests, there were statistically significant differences in neutrophils, lymphocytes, red blood cells, C-reactive protein, D-dimer, aspartate aminotransferase, and creatinine among the three groups (p < 0.05). In imaging examinations, there were statistically significant differences among the three groups in terms of unilateral pulmonary inflammation, bilateral pulmonary inflammation, and bilateral pleural effusion (p < 0.05). There were statistically significant differences among the three groups in terms of antibiotic treatment, steroid treatment, oxygen therapy, nasal cannula oxygen inhalation therapy, non-invasive ventilation, and tracheal intubation ventilation (p < 0.05). Regarding clinical outcomes, there were statistically significant differences among the three groups in terms of mortality (p < 0.05). Multivariate logistic regression analysis showed that CRP (OR = 1.012, 95% CI = 1.004–1.019) and D-dimer (OR = 1.117, 95% CI = 1.021–1.224) were independent risk factors for patient mortality. The predictive value of CRP, D-dimer, and CK-MB for the risk of death was assessed. D-dimer had the highest sensitivity (95.8%) in predicting patient mortality risk, while CRP had the highest specificity (84.4%).ConclusionFor patients with COVID-19 and concomitant cardiovascular diseases without contraindications, early administration of COVID-19 vaccines and booster shots can effectively reduce the mortality rate of severe cases. Monitoring biomarkers such as CRP, D-dimer, and CK-MB and promptly providing appropriate care can help mitigate the risk of mortality in patients