18 research outputs found
Resisting the West: The Clinton Administration\u27s Promotion of Abortion at the 1994 Cairo Conference and the Strength of the Islamic Response
Resisting the West: The Clinton Administration\u27s Promotion of Abortion at the 1994 Cairo Conference and the Strength of the Islamic Response
HyBryteâ„¢ use in early-stage cutaneous T-cell lymphoma
Cutaneous T-cell lymphoma (CTCL) is a rare type of non-Hodgkin lymphoma of the skin, where at later stages skin-homing malignant T-cells affect lymph nodes, blood, and visceral organs. Even though early CTCL does not affect survival, it can progress to more advanced stages of disease and have a significant effect on the quality of life of patients. Although expectant management is a treatment consideration in early disease stages, most patients cycle through different skin-directed therapies throughout their lifetime. It can become a challenge to manage the serious and accumulating risk of side effects of these therapies, including various skin cancers and skin damage. Adverse effects from topical therapies limit their long-term utility. Thus, there is an unmet need for well-characterized therapies that have a rapid onset of action and minimal long-term/cumulative side effect profile. Most recently, the results of a Phase 3 study of topical HyBryteâ„¢ as a potential treatment for CTCL demonstrated its efficacy and safety profile. This article summarizes what is known about HyBryteâ„¢, focuses on its mechanism of action, and highlights its effectiveness, safety, and tolerability in the context of other current FDA-approved topical therapies for CTCL
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Panama and the Myth of Humanitarian Intervention in U.S. Foreign Policy: Neither Legal Nor Moral, Neither Just Nor Right [Article]
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