Dark Matter, Sparticle Spectroscopy and Muon (g−2)(g-2) in SU(4)c×SU(2)L×SU(2)RSU(4)_c \times SU(2)_L \times SU(2)_R

We explore the sparticle mass spectra including LSP dark matter within the framework of supersymmetric $SU(4)_c \times SU(2)_L \times SU(2)_R$ (422) models, taking into account the constraints from extensive LHC and cold dark matter searches. The soft supersymmetry-breaking parameters at $M_{GUT}$ can be non-universal, but consistent with the 422 symmetry. We identify a variety of coannihilation scenarios compatible with LSP dark matter, and study the implications for future supersymmetry searches and the ongoing muon g-2 experiment.Comment: 21 pages, 8 fig

The B1 shock in the L1157 outflow as seen at high spatial resolution

We present high spatial resolution (750 AU at 250 pc) maps of the B1 shock in the blue lobe of the L1157 outflow in four lines: CS (3-2), CH3OH (3_K-2_K), HC3N (16-15) and p-H2CO (2_02-3_01). The combined analysis of the morphology and spectral profiles has shown that the highest velocity gas is confined in a few compact (~ 5 arcsec) bullets while the lowest velocity gas traces the wall of the gas cavity excavated by the shock expansion. A large velocity gradient model applied to the CS (3-2) and (2-1) lines provides an upper limit of 10^6 cm^-3 to the averaged gas density in B1 and a range of 5x10^3< n(H2)< 5x10^5 cm^-3 for the density of the high velocity bullets. The origin of the bullets is still uncertain: they could be the result of local instabilities produced by the interaction of the jet with the ambient medium or could be clump already present in the ambient medium that are excited and accelerated by the expanding outflow. The column densities of the observed species can be reproduced qualitatively by the presence in B1 of a C-type shock and only models where the gas reaches temperatures of at least 4000 K can reproduce the observed HC3N column density.Comment: 13 pages, 12 figure

ANÁLISIS DEL COSTE CONSTRUCTIVO DE SALAS DE CRIANZA AÉREAS PARA VINO TINTO

El sector vitivinícola español se encuentra inmerso en un importante proceso de actualización y renovación, no sólo en cuanto a superficie de viñedo, sino también en cuanto al nivel de inversión que se ha destinado a la edificación de nuevas bodegas, a la mejora de las instalaciones y equipamientos y a la utilización de técnicas de envejecimiento distintas para ofrecer una gama mucho más amplia de vinos de calidad. En este contexto se ha desarrollado el proyecto “Estrategias de diseño bioclimático en bodegas como modelo de edificios de consumo de energía casi nulo”, que planteando un ambicioso estudio global y a gran escala, ha analizado un importante número de bodegas repartidas por todo el territorio español, representativas de los principales diseños constructivos. En el presente trabajo se analiza y cuantifica el coste actualizado de naves de crianza en superficie ubicadas en regiones vitivinícolas destacadas. La documentación técnica de la ejecución de las bodegas analizadas (proyecto, planos, certificados de obra, etc.), fue revisada y complementada con inspecciones y visitas realizadas a dichas bodegas, obteniendo presupuestos actualizados con base de precios de 2018. Los resultados obtenidos son una valiosa herramienta para el diseño de nuevas salas de crianza en superficie

Plasma calprotectin as a biomarker of ultrasound synovitis in rheumatoid arthritis patients receiving IL-6 antagonists or JAK inhibitors

To analyse the accuracy of plasma calprotectin in patients with rheumatoid arthritis (RA) receiving monoclonal antibodies against IL-6 receptors (anti-rIL-6) or JAK inhibitors (JAKis) in detecting ultrasound (US) synovitis and compare it with acute phase reactants [high-sensitivity C-reactive protein (hs-CRP) and ESR].An observational cross-sectional study of RA patients receiving anti-rIL-6 (tocilizumab or sarilumab) or JAKi, (baricitinib or tofacitinib) was made. Plasma calprotectin for the diagnosis of US synovitis [synovial hypertrophy grade (SH)???2 plus power Doppler signal (PD)???1] was analysed using receiver operating characteristic curves (ROCs). The performance of ESR and hs-CRP was also studied. The three ROC curves were compared to determine which had the highest discriminatory power. Associations between plasma calprotectin and US scores were made using correlation analysis.Sixty-three RA patients were included. Mean plasma calprotectin levels were significantly higher in patients with US synovitis than in those without (0.89?±?0.85 vs 0.30?±?0.12 ?g/ml; p?=?0.0003). A moderate correlation between calprotectin and all US scores (HS score Rho?=?0.479; PD score Rho?=?0.492; and global score Rho?=?0.495) was found. The discriminatory capacity of plasma calprotectin showed an AUC of 0.795 (95% CI: 0.687-0.904). The AUC of hs-CRP and ESR was 0.721 and 0.564, respectively. hs-CRP serum levels showed a low positive correlation with the three US scores (Rho?<?0.40). After analysis according to the drugs administered, the correlation disappeared in patients receiving anti-rIL-6.Plasma calprotectin may be a sensitive biomarker of synovial inflammation in RA patients treated with anti-rIL-6 or JAKi.© The Author(s), 2022

Does the ACE I/D polymorphism, alone or in combination with the ACTN3 R577X polymorphism, influence muscle power phenotypes in young, non-athletic adults?

We investigated the association of the angiotensin converting enzyme gene (ACE) insertion/deletion (I/D) polymorphism, alone or in combination with the α-actinin-3 gene (ACTN3) R577X polymorphism, with jumping (vertical squat and counter-movement jump tests) and sprint ability (30 m dash) in non-athletic, healthy young adults [N = 281 (214 male), mean (SD) age 21 (2) years]. We did not observe any effect of the ACE I/D polymorphism on study phenotypes. We repeated the analyses separately in men and women and the results did not materially change. Likewise, the mean estimates of the study phenotypes were similar in subjects with the genotype combinations ACE II + ID and ACTN3 XX or ACE DD and ACTN3 RR + RX. We found no association between the ACE DD and ACTN3 RR + RX genotype combination and performance (≥90th of the sex-specific percentile). In summary, though the ACE I/D polymorphism is a strong candidate to modulate some exercise-related phenotypes or athletic performance status, this polymorphism, alone or in combination with the ACTN3 R577X polymorphism, does not seem to exert a major influence in the muscle ‘explosive’ power of young healthy adults, as assessed during multi-joint exercise tests