Aqua­(1,10-phenanthroline-κ2 N,N′)(valinato-κ2 N,O)copper(II) nitrate dihydrate

In the title compound, [Cu(C5H10NO2)(C12H8N2)(H2O)]NO3·2H2O, the CuII atom displays a distorted square-pyramidal coordination (τ = 0.03) where the water mol­ecule occupies the apical position and the base is defined by the N atom, one of the O atoms from the valinate ligand, and both phenanthroline N atoms. The phenanthroline chelate ring plane is slightly distorted from planarity (r.m.s. deviation = 0.0057 Å), whereas the five-membered ring formed by the valinate ligand presents an envelope conformation with the N atom being the flap atom. The crystal packing is stabilized by O—H⋯O and N—H⋯O hydrogen-bonding inter­actions, creating a three-dimensional network superstructure

Aqua­[1,8-bis­(pyridin-2-yl)-3,6-dithia­octane-κ4 N,S,S′,N′]copper(II) dinitrate acetonitrile monosolvate

In the title compound, [Cu(C16H20N2S2)(H2O)](NO3)2·CH3CN, the CuII atom displays a distorted square-pyramidal coordination, in which a water mol­ecule occupies the apical position and the basal plane is formed by two N atoms and two S atoms of a 1,8-bis­(pyridin-2-yl)-3,6-dithia­octane ligand. The crystal packing is stabilized by O—H⋯O and C—H⋯O hydrogen bonds

Development and In Vitro and In Vivo Evaluation of an Antineoplastic Copper(II) Compound (Casiopeina III-ia) Loaded in Nonionic Vesicles Using Quality by Design

In recent decades, the interest in metallodrugs as therapeutic agents has increased. Casiopeinas are copper-based compounds that have been evaluated in several tumor cell lines. Currently, casiopeina III-ia (CasIII-ia) is being evaluated in phase I clinical trials. The aim of the present work is to develop a niosome formulation containing CasIII-ia for intravenous administration through a quality-by-design (QbD) approach. Risk analysis was performed to identify the factors that may have an impact on CasIII-ia encapsulation. The developed nanoformulation optimized from the experimental design was characterized by spectroscopy, thermal analysis, and electronic microscopy. In vitro drug release showed a burst effect followed by a diffusion-dependent process. The niosomes showed physical stability for at least three months at 37 °C and 75% relative humidity. The in vitro test showed activity of the encapsulated CasIII-ia on a metastatic breast cancer cell line and the in vivo test of nanoencapsulated CasIII-ia maintained the activity of the free compound, but showed a diminished toxicity. Therefore, the optimal conditions obtained by QbD may improve the scaling-up process

New 3rd Generation of Casiopeinas Family Compounds with Indomethacin as a Secondary Ligand: Synthesis, Characterization, Antiproliferative Activity, and Nanoencapsulation

The search for new molecules with greater antitumor activity as well as new forms of administration of chemotherapeutic drugs are the task of this work. [...

Regression of an Epidermoid Carcinomas in Domestic Canine Treated with Casiopeína® IIgly

Squamous cell carcinoma (SCC) is a malignancy that has no treatment. [...

Tris(5,6-dimethyl-1,10-phenanthroline-κ2N,N′)copper(II) bis(hexafluoridophosphate) acetonitrile monosolvate

In the title compound, [Cu(C14H12N2)3](PF6)2·CH3CN, the [Cu(5,6-dmp)3]2+ cationic complex (5,6-dmp is 5,6-dimethyl-1,10-phenanthroline) is stabilized by two hexafluoridophosphate anions and one acetonitrile solvent molecule. The coordination geometry around the CuII atom can be described as distorted elongated octahedral with Rout = 2.277 (2) Å, Rin = 2.052 (2) Å and a tetragonality of 0.9011, acquiring a `static' stereochemistry. In the supramolecular network, there are intermolecular C—H...F and C—H...N interactions with R33(16), R22(7), R12(4), R33(16) and C32(7) motifs that lead to an infinite three-dimensional network

ELECTROCHEMICAL STUDY OF CIS-DIFERROCENYLETHENE DERIVATES

Ferrocene derivatives have been used in the synthesis of polymeric materials with thermal resistance and nonlinear optical properties, and in the field of supramolecular electrochemistry as redox switching receptors. For these reasons, during the past few years the electrochemical studies on ferrocenyl derivatives have been growing up. In order to characterize molecules with potential uses in the synthesis of polymeric materials and to understand its electrochemical functioning, this paper presents electrochemical studies on these chemicals: 1) cis-diferrocenylethenes derivates (Isopropyl cis-2,3-Diferrocenylacrylate; 2) cis-2,3-Diferrocenylacrylic Acid; 3) cis-2,3- Diferrocenylacrylohydrazide; 4) cis-2,3-Diferrocenylacrylic Acid Piperidide; 5) cis-3,4- Diferrocenyl-2-methylbut-3-en-ol, and 6) cis-1,1-Diphehyl-2,3-Diferrocenylprop-2-en-1-ol. All of the chemicals presented two oxidation processes (I-II), which were thought to be caused by the oxidation of the ferrocene groups, E1/2(I), E1/2(II), ¿E1/2 (II-I). The comproportionation constant Kcom was calculated. According to this value, it can be proposed that the molecules containing a carbonyl group (1-4) present larger electronic communication compared to molecules with a hydroxy group (5-6). Uv-vis espectra of all compounds in butironitrile solution were obtained. A correlation between Kcom and ¿ max was also observed