153 research outputs found

    Los retos del sector bancario español

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    Evento: Seminario 'La Cuarta revolución. ¿Cómo afecta la agenda digital a la economía y a la industria?. Organizado por: UIMP - APIE (Santander)Incluye versión en inglé

    Bancos, confianza y nuevas tecnologías

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    Evento: La banca ante los retos de la regulación, la rentabilidad y la digitalización. VIII Encuentro financiero. Organizado por: Expansión y KPMGIncluye versión en inglé

    Retos y oportunidades del sector bancario español. Discurso de apertura

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    Evento: 2ª Jornada del XXIV Encuentro del Sector Bancario, 'Un sector en transformación'. Organizado por: ABC, Deloitte y Sociedad de TasaciónIncluye versión en inglé

    La relación con el cliente bancario

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    Evento: 13 Encuentro del Sector Bancario 'Una Banca competitiva en una nueva sociedad'. Organizado por: IESE (Madrid)Incluye versión en inglé

    H3K18 lactylation marks tissue‑specific active enhancers

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    Background: Histone lactylation has been recently described as a novel histone posttranslational modification linking cellular metabolism to epigenetic regulation. Results: Given the expected relevance of this modification and current limited knowledge of its function, we generate genome-wide datasets of H3K18la distribution in various in vitro and in vivo samples, including mouse embryonic stem cells, macrophages, adipocytes, and mouse and human skeletal muscle. We compare them to profiles of well-established histone modifications and gene expression patterns. Supervised and unsupervised bioinformatics analysis shows that global H3K18la distribution resembles H3K27ac, although we also find notable differences. H3K18la marks active CpG islandcontaining promoters of highly expressed genes across most tissues assessed, including many housekeeping genes, and positively correlates with H3K27ac and H3K4me3 as well as with gene expression. In addition, H3K18la is enriched at active enhancers that lie in proximity to genes that are functionally important for the respective tissue. Conclusions: Overall, our data suggests that H3K18la is not only a marker for active promoters, but also a mark of tissue specific active enhancers.ETH Zurich ETH Zurich core fundingEuropean Research Council (ERC) European Commission 803491Botnar Research Centre for Child Health Multi-Investigator ProjectWorld Food System Center of ETH ZurichIntegrative Food and Nutrition Center of EPF

    The NADPH-Dependent thioredoxin reductase C-2-Cys peroxiredoxin redox system modulates the activity of thioredoxin x in arabidopsis chloroplasts

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    The chloroplast redox network is composed of a complex set of thioredoxins (Trxs), reduced by ferredoxin (Fdx) via a Fdx-dependent Trx reductase (FTR), and an NADPH-dependent Trx reductase with a joint Trx domain, NTRC, which efficiently reduces 2-Cys peroxiredoxins (2-Cys Prxs). Recently, it was proposed that the redox balance of 2-Cys Prxs maintains the redox state of f-type Trxs, thus allowing the proper redox regulation of Calvin-Benson cycle enzymes such as fructose 1,6-bisphosphatase (FBPase). Here, we have addressed whether the action of 2-Cys Prxs is also exerted on Trx x. To that end, an Arabidopsis thaliana quadruple mutant, ntrc-trxx-δ "2cp, which is knocked out for NTRC and Trx x, and contains severely decreased levels of 2-Cys Prxs, was generated. In contrast to ntrc-trxx, which showed a severe growth inhibition phenotype and poor photosynthetic performance, the ntrc-trxx-δ "2cp mutant showed a significant recovery of growth rate and photosynthetic efficiency, indicating that the content of 2-Cys Prxs is critical for the performance of plants lacking both NTRC and Trx x. Light-dependent reduction of FBPase was severely impaired in mutant plants lacking NTRC or NTRC plus Trx x, despite the fact that neither NTRC nor Trx x is an effective reductant of this enzyme. However, FBPase reduction was recovered in the ntrc-trxx-δ "2cp mutant. Our results show that the redox balance of 2-Cys Prxs, which is mostly dependent on NTRC, modulates the activity of Trx x in a similar way as f-type Trxs, thus suggesting that the activity of these Trxs is highly interconnected.Ministerio de Economía y Competitividad BIO2017-85195-C2-1-

    Los retos del sistema financiero

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    Evento: Jornada 'Los retos de la banca europea: rentabilidad y modelos de negocio'. Organizado por: Cinco Días y Abanca (Madrid

    El reto de la educación financiera

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    Evento: Clausura del seminario 'La economía ante el blockchain. Lo que está por venir'. Organizado por: Universidad Internacional Menéndez Pelayo (UIMP) y la Asociación de Periodistas de Información Económica (APIE) (Santander
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