Revisión sobre el uso de la teledetección en la monitorización y predicción del almacenamiento de carbono en tierras marginales

[EN] In recent years, Remote Sensing (RS) and its derived products have been used as a key tool for the detection, monitoring, management and future use of Marginal Lands (ML). Currently, there is no single, universally accepted definition of the term and there is a wide variety of synonyms. In this paper, we conduct a compilation of synonyms and meanings that encompass the term, as well as propose a definition. To reach this objective, an overview of the state of the art of ML is done, visualising trends by science maps, based on bibliographic data of established research journals, found in Google Scholar, Web of Science (WoS) and Scopus search engines. The bibliographic review carried out shows that the study of ML has traditionally been carried out with an ad hoc basis focused on the objective to be achieved, this aspect and other knowledge gaps are discussed to analyse the global study of ML. Due to the broad spectrum of uses in which ML have been studied, the work has been focused on RS for monitoring and characterizing ML, focusing on two different aspects: (i) satellite monitoring of marginal lands; and (ii) determining carbon sequestration potential of marginal lands using remote sensing.[ES] En los últimos años, la teledetección y sus productos derivados se han utilizado como herramienta clave para la detección, seguimiento, gestión y uso futuro de las tierras marginales (ML). Actualmente, no existe una definición única y universalmente aceptada del término y existe una gran variedad de sinónimos. En este artículo llevamos a cabo una recopilación de sinónimos y significados que engloban el término, además de proponer una definición universal. Para alcanzar este objetivo, se realiza un resumen del estado del arte de las ML, visualizando las tendencias mediante mapas científicos, basadas en datos bibliográficos de revistas de investigación consolidadas, encontradas en los buscadores Google Scholar, Web of Science (WoS) y Scopus. La revisión bibliográfica realizada muestra que el estudio de las ML se ha realizado tradicionalmente con una base ad hoc centrada en el objetivo a alcanzar. Se discute este aspecto y otras lagunas de conocimiento para analizar el estudio global de las tierras marginales. Debido al amplio espectro de usos en que se han estudiado las tierras marginales, los trabajos se han centrado en la teledetección para su seguimiento y caracterización, centrándose en dos aspectos diferentes: (i) el seguimiento por satélite de las tierras marginales; y (ii) determinación de su potencial en el almacenamiento de carbono mediante teledetección.This work was supported by the Spanish Ministerio de Economía, Industria y Competitividad through the scholarship for Training of Research Staff BES-2017-081920 and the European Commission through the H2020-MSCA-RISE-2018 MAIL project under Grant Agreement 823805.Carbonell-Rivera, JP.; Estornell, J.; Ruiz, L.; Abad, A.; Felten, B.; Torralba, J. (2021). A review of the use of remote sensing for monitoring and quantifying carbon sequestration in marginal lands. En Proceedings 3rd Congress in Geomatics Engineering. Editorial Universitat Politècnica de València. 216-223. https://doi.org/10.4995/CiGeo2021.2021.12694OCS21622

A distal to proximal gradient of human choroid plexus development, with antagonistic expression of Glut1 and AQP1 in mature cells vs. calbindin and PCNA in proliferative cells

The choroid plexuses (ChP) are highly vascularized tissues suspended from each of the cerebral ventricles. Their main function is to secret CSF that fills the ventricles and the subarachnoid spaces, forming a crucial system for the development and maintenance of the CNS. However, despite the essential role of the ChP–CSF system to regulate the CNS in a global manner, it still remains one of the most understudied areas in neurobiology. Here we define by immunohistochemistry the expression of different proteins involved in the maturation and functionality of the ChP from the late embryological period to maturity. We found an opposite gradient of expression between AQP1 and Glut1 that define functional maturation in the ChP periphery, and PCNA and calbindin, present in the ChP roof zone with proliferative activity. We conclude that the maturation of the ChP matures from distal to proximal, starting in the areas nearest to the cortex, expressing in the distal, mature areas AQP1 and Glut1 (related to ChP functionality to support cortex development), and in the proximal immature areas (ChP root) calbindin and PCNA related to progenitor activity and proliferation

Visión actual de la apicultura en españa

La apicultura es una actividad agropecuaria orientada a la cría de abejas para obtener beneficios derivados de la venta de los productos apícolas y de la acción polinizadora en los cultivos. Es un sector que se distribuye principalmente en Castilla y León con el 16% del total de explotaciones, de las cuales la mayoría son no profesionales y estantes. Le siguen en importancia Galicia con el 14,3% de explotaciones, y Andalucía con el 13%, donde están a la par las colmenas profesionales y no profesionales con trashumancia. Dentro del panorama comunitario, España ocupa el primer lugar en el censo con un 17,1% del total de colmenas de Europa, con un volumen exportador del 27,9%; los destinos principales son Francia y Alemania. En el plano extracomunitario, España importa miel de China y Argentina ocupando el 5º lugar (3,4%) de las importaciones a nivel mundial. No obstante el nivel de autoabastecimiento español alcanza un 88,2%.The beekeeping is a farming activity orientated to the young of bees in order to obtain benefits derived from the sale of apicultural products and the pollinating action on the cultivates. It’s a sector distributed mainly in Castilla and Leon with 16% of the total of operations, of which the majority is nonprofessional and permanent. They are followed in importance by Galicia with 14.3% of operations, and Andalucia with 13% where the non professional beehives with seasonal migrations are similar.Within the communitarian perspective, Spain occupies the first place in the census with the 17.1% of the total of beehives of Europe, with an exporting volume of 27,9%; the main destinies are France and Germany. In the extracommunitarian plane, Spain imports honey from China and Argentina occupying the fifth place (3.4%) of the imports at world-wide level. Despite the level of Spanish self-supplying it reaches a 88.2%

El papel del valor de la marca propia en la composición del surtido del minorista: su influencia sobre la lealtad al establecimiento

El objetivo del presente trabajo es conocer la influencia del valor de la MdD, en diferentes tipos de surtido, sobre la lealtad de los consumidores hacia el establecimiento, tanto para una categoría de producto como para la cesta de la compra. Para ello, consideramos surtidos con diferente tamaño y estructura (solo MdD y mixtos) y desarrollamos un experimento online con una muestra de 1.400 consumidores en España. A partir de un análisis ANOVA, los resultados solo muestran diferencias significativas en surtidos mixtos donde la MF de alto valor tiene poco peso, no encontrándose diferencias significativas en surtidos con solo MdD, ni en surtidos mixtos con mayor proporción de MF de alto valor. Estos resultados sugieren diferentes recomendaciones para los minoristas, dependiendo del tipo de surtido por el que optenThe objective of this work is to know the influence of the PL equity, in different structures of the assortment, on the consumer’s loyalty towards the store, for both a product category and the shopping basket. Thus, we consider assortments with different sizes and composition (PL-only and mixed) and develop an online experiment with a sample of 1,400 consumers in Spain. Through an ANOVA analysis, the results only show significant differences in mixed assortments where NBs high equity represent a low ratio, not finding significant differences in PL-only assortments, nor in mixed assortments with a higher ratio of NBs high equity. These results suggest different suggestions for retailers, depending on the type of assortmen

The purinergic P2X7 receptor as a potential drug target to combat neuroinflammation in neurodegenerative diseases

Neurodegenerative diseases (NDDs) represent a huge social burden, particularly in Alzheimer's disease (AD) in which all proposed treatments investigated in murine models have failed during clinical trials (CTs). Thus, novel therapeutic strategies remain crucial. Neuroinflammation is a common pathogenic feature of NDDs. As purinergic P2X7 receptors (P2X7Rs) are gatekeepers of inflammation, they could be developed as drug targets for NDDs. Herein, we review this challenging hypothesis and comment on the numerous studies that have investigated P2X7Rs, emphasizing their molecular structure and functions, as well as their role in inflammation. Then, we elaborate on research undertaken in the field of medicinal chemistry to determine potential P2X7R antagonists. Subsequently, we review the state of neuroinflammation and P2X7R expression in the brain, in animal models and patients suffering from AD, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, multiple sclerosis, and retinal degeneration. Next, we summarize the in vivo studies testing the hypothesis that by mitigating neuroinflammation, P2X7R blockers afford neuroprotection, increasing neuroplasticity and neuronal repair in animal models of NDDs. Finally, we reviewed previous and ongoing CTs investigating compounds directed toward targets associated with NDDs; we propose that CTs with P2X7R antagonists should be initiated. Despite the high expectations for putative P2X7Rs antagonists in various central nervous system diseases, the field is moving forward at a relatively slow pace, presumably due to the complexity of P2X7Rs. A better pharmacological approach to combat NDDs would be a dual strategy, combining P2X7R antagonism with drugs targeting a selective pathway in a given NDD.The authors would like to acknowledge the support received from the EU Horizon 2020 Research and Innovation Program under Maria Sklodowska‐Curie (Grant Agreement No. 766124). The authors would also like to thank the support received from the Ministerio de Economía y Competitividad (MINECO, Spain; Grant No. SAF2016‐78892R to Luis Gandía and Antonio G. García) and Fundación Teófilo Hernando

PKM2 subcellular localization is involved in oxaliplatin resistance acquisition in HT29 human colorectal cancer cell lines

Ajuts: Beca bianual de la Fundació Olga Torres 2008-2009Chemoresistance is the main cause of treatment failure in advanced colorectal cancer (CRC). However, molecular mechanisms underlying this phenomenon remain to be elucidated. In a previous work we identified low levels of PKM2 as a putative oxaliplatin-resistance marker in HT29 CRC cell lines and also in patients. In order to assess how PKM2 influences oxaliplatin response in CRC cells, we silenced PKM2 using specific siRNAs in HT29, SW480 and HCT116 cells. MTT test demonstrated that PKM2 silencing induced resistance in HT29 and SW480 cells and sensitivity in HCT116 cells. Same experiments in isogenic HCT116 p53 null cells and double silencing of p53 and PKM2 in HT29 cells failed to show an influence of p53. By using trypan blue stain and FITC-Annexin V/PI tests we detected that PKM2 knockdown was associated with an increase in cell viability but not with a decrease in apoptosis activation in HT29 cells. Fluorescence microscopy revealed PKM2 nuclear translocation in response to oxaliplatin in HCT116 and HT29 cells but not in OXA-resistant HTOXAR3 cells. Finally, by using a qPCR Array we demonstrated that oxaliplatin and PKM2 silencing altered cell death gene expression patterns including those of BMF, which was significantly increased in HT29 cells in response to oxaliplatin, in a dose and time-dependent manner, but not in siPKM2-HT29 and HTOXAR3 cells. BMF gene silencing in HT29 cells lead to a decrease in oxaliplatin-induced cell death. In conclusion, our data report new non-glycolytic roles of PKM2 in response to genotoxic damage and proposes BMF as a possible target gene of PKM2 to be involved in oxaliplatin response and resistance in CRC cells

Syngas/H2 production from bioethanol in a continuous Chemical-Looping Reforming prototype

Chemical-looping reforming (CLR) allows H2 production without CO2 emissions into the atmosphere. The use of a renewable fuel, bioethanol, in an auto-thermal CLR process has the advantage to produce H2 with negative CO2 emissions. This work presents the experimental results obtained in a continuously operating CLR unit (1 kWth) using ethanol as fuel. Two NiO-based oxygen carriers were used during more than 50 h of operation. The influence of variables such as temperature, water-to-fuel and oxygen-to-fuel molar ratios was analysed. Full conversion of ethanol was accomplished and carbon formation was easily avoided. A syngas composed of ≈ 61 vol.% H2, ≈ 32 vol.% CO, ≈ 5 vol.% CO2 and ≈ 2 vol.% CH4 was reached at auto-thermal conditions for both materials. Gas composition was closed to the given by the thermodynamic equilibrium. These results demonstrate the technical viability of H2/syngas production by using bioethanol in an auto-thermal CLR process.This work is partially supported by the Spanish Ministry for Science and Innovation (MICINN project ENE2011-26354) and the European Regional Development Fund (ERDF), and by CTGAS-ER (project OTT20130989). A. Serrano also thanks the Spanish Ministry of Economy and Competitiveness for the F.P.I. fellowshipPeer reviewe

Polymorphisms of the farnesyl diphosphate synthase gene modulate bone changes in response to atorvastatin

Producción CientíficaAlthough their primary therapeutic indications are different, aminobisphosphonates and statins target enzymes in the mevalonate pathway, which is critical for bone homeostasis. Previous studies have shown that some polymorphisms of the gene encoding farnesyl diphosphate synthase (FDPS), the main target of aminobisphosphonates, modulate the response to these drugs. In this study, we explored whether those single nucleotide polymorphisms (SNPs) also influence the changes in bone mineral density (BMD) following therapy with statins. Sixty-six patients with coronary heart disease were studied at baseline and after 1-year therapy with atorvastatin. BMD was measured by DXA. Three SNPs of the FDPS gene (rs2297480, rs11264359 and rs17367421) were analyzed by using Taqman assays. The results showed that there was no association between the SNPs and basal BMD. However, rs2297480 and rs11264359 alleles, which are in linkage disequilibrium, were associated with changes in hip BMD following atorvastatin therapy. Thus, patients with AA genotype at the rs2297480 locus had a 0.8 ± 0.8 % increase in BMD at the femoral neck, whereas in patients with AC/CC genotypes, BMD showed a 2.3 ± 0.8 % decrease (p = 0.02). Similar results were obtained regarding changes of BMD at the femoral trochanter and when alleles at the rs11264359 locus were analyzed. However, there was no association between BMD and rs17367421 alleles. In conclusion, these results suggest that polymorphisms of the FDPS gene may influence the bone response to various drugs targeting the mevalonate pathway, including not only aminobisphosphonates but also statins

Nitrogen, Iron, and Zinc Acquisition: Key Nutrients to Aspergillus fumigatus Virulence

Aspergillus fumigatus is a ubiquitous soil decomposer and an opportunistic pathogen that is characterized by its large metabolic machinery for acquiring nutrients from media. Lately, an ever-increasing number of genes involved in fungal nutrition has been associated with its virulence. Of these, nitrogen, iron, and zinc metabolism-related genes are particularly noteworthy, since 78% of them have a direct implication in virulence. In this review, we describe the sensing, uptake and regulation process of the acquisition of these nutrients, the connections between pathways and the virulence-implicated genes. Nevertheless, only 40% of the genes mentioned in this review have been assayed for roles in virulence, leaving a wide field of knowledge that remains uncertain and might offer new therapeutic and diagnostic targets.This research was funded by the Basque Government: grant number IT1362-19. U.P.-C. and S.C.-S. received a predoctoral fellowship from the University of the Basque Country and Basque Government, respectively