Poly[di-μ9-citrato-cobalt(II)tetra­sodium]

The title compound, [CoNa4(C6H5O7)2]n, was obtained under hydro­thermal conditions as a minor product. The Co2+ cation is located on a crystallographic inversion center and is coordinated by six O atoms from two different citrate units, forming a [Co(C6H5O7)2]4− building unit with Co—O bond lengths between 2.0578 (17) and 2.0813 (16) Å. The structure features two crystallographically independent Na+ ions. The first Na+ cation is five-coordinated by O atoms of five carboxylate groups from four different citrate anions. The second Na+ cation is surrounded by six O atoms of five carboxylate groups from five different citrate anions. The carboxylate groups of the citrate are completely depronona­ted, the hydroxyl group, however, is not. It is coordinated to the Co2+ cation, and through an O—H⋯O hydrogen bond connected to a neighboring [Co(C6H5O7)2]4− building unit. The coordination modes of the carboxyl­ate O atoms vary, with one O atom being coordinated to three different Na+ cations, three are bridging O atoms bound to two Na+ cations and two are connected to a Co2+ cation and a Na+ cation, respectively. Through these inter­connections, the basic [Co(C6H5O7)2]4− building units are linked with each other through coordination of their carboxyl­ate groups to the Na+ cations, forming a three-dimensional framework

catena-Poly[[gallium(III)-bis[μ-D/l-tartrato(2−)]-gallium(III)-di-μ-hydroxido] dihydrate]

In the title compound, {[Ga2(C4H4O6)2(OH)2]·2H2O}n, the GaIII atom is located on a twofold rotation axis and is six-coordinated by two O atoms from bridging hydroxide groups and four O atoms from two symmetry-related tartrate units in a slightly distorted octahedral environment. Each tartrate unit binds to two GaIII atoms as a bis-chelating bridging ligand by two pairs of hydroxide groups and an O atom of a carboxylate group. The GaIII atoms are linked by two bridging hydroxide groups located on mirror planes. In this way a chain along the c axis is formed. Free water molecules on mirror planes are located between the chains and hold them together through hydrogen-bonding interactions, with O...O distances in the range 2.509 (3)–3.179 (5) Å

Characterization of the complete chloroplast genome of Taxus wallichiana as the medicinal plant from China

Taxus wallichiana is a member of the family Taxaceae, which is a unique and endangered species in China and is widely used for ornamental, material and medicinal purposes. The complete chloroplast genome of T. wallichiana was found to possess a total size of 128,168 bp. The GC content of T. wallichiana chloroplast genome sequence is 37.3%, the overall nucleotide composition of chloroplast genome sequence is: A of 30.7%, T of 32.0%, C of 19.0% and G of 18.3%. The total of 116 genes were successfully annotated, which contained 83 protein-coding genes, 29 transfer RNA genes, and 4 ribosomal RNA genes. The ML phylogenetic analysis result showed that T. wallichiana was closely related to Taxus baccata in the phylogenetic relationship using the neighbour-joining (NJ) method in this study

UiO-66 nanoparticles combat influenza A virus in mice by activating the RIG-I-like receptor signaling pathway

Abstract The Influenza A virus (IAV) is a zoonotic pathogen that infects humans and various animal species. Infection with IAV can cause fever, anorexia, and dyspnea and is often accompanied by pneumonia characterized by an excessive release of cytokines (i.e., cytokine storm). Nanodrug delivery systems and nanoparticles are a novel approach to address IAV infections. Herein, UiO-66 nanoparticles (NPs) are synthesized using a high-temperature melting reaction. The in vitro and in vivo optimal concentrations of UiO-66 NPs for antiviral activity are 200 μg mL−1 and 60 mg kg−1, respectively. Transcriptome analysis revealed that UiO-66 NPs can activate the RIG-I-like receptor signaling pathway, thereby enhancing the downstream type I interferon antiviral effect. These NPs suppress inflammation-related pathways, including the FOXO, HIF, and AMPK signaling pathways. The inhibitory effect of UiO-66 NPs on the adsorption and entry of IAV into A549 cells is significant. This study presents novel findings that demonstrate the effective inhibition of IAV adsorption and entry into cells via UiO-66 NPs and highlights their ability to activate the cellular RIG-I-like receptor signaling pathway, thereby exerting an anti-IAV effect in vitro or in mice. These results provide valuable insights into the mechanism of action of UiO-66 NPs against IAV and substantial data for advancing innovative antiviral nanomedicine. Graphical Abstrac