1,021 research outputs found
Entanglement dynamics for two harmonic oscillators coupled to independent environments
We study the entanglement evolution between two harmonic oscillators having
different free frequencies each leaking into an independent bath. We use an
exact solution valid in the weak coupling limit and in the short time
non-Markovian regime. The reservoirs are identical and characterized by an
Ohmic spectral distribution with Lorents-Drude cut-off. This work is an
extension of the case reported in [Phys. Rev. A 80, 062324 (2009)] where the
oscillators have the same free frequency.Comment: 8 pages, 3 figures, submitted to Physica Script
BAFF Index and CXCL13 levels in the cerebrospinal fluid associate respectively with intrathecal IgG synthesis and cortical atrophy in multiple sclerosis at clinical onset
Abstract
Background
B lymphocytes are thought to play a relevant role in multiple sclerosis (MS) pathology. The in vivo analysis of intrathecally produced B cell-related cytokines may help to clarify the mechanisms of B cell recruitment and immunoglobulin production within the central nervous system (CNS) in MS.
Methods
Paired cerebrospinal fluid (CSF) and serum specimens from 40 clinically isolated syndrome suggestive of MS or early-onset relapsing-remitting MS patients (CIS/eRRMS) and 17 healthy controls (HC) were analyzed for the intrathecal synthesis of IgG (quantitative formulae and IgG oligoclonal bands, IgGOB), CXCL13, BAFF, and IL-21. 3D-FLAIR, 3D-DIR, and 3D-T1 MRI sequences were applied to evaluate white matter (WM) and gray matter (GM) lesions and global cortical thickness (gCTh).
Results
Compared to HC, CIS/eRRMS having IgGOB (IgGOB+, 26 patients) had higher intrathecal IgG indexes ( p \u2009<\u20090.01), lower values of BAFF Index (11.9\u2009\ub1\u20096.1 vs 17.5\u2009\ub1\u20095.2, p \u2009<\u20090.01), and higher CSF CXCL13 levels (27.7\u2009\ub1\u200933.5 vs 0.9\u2009\ub1\u20091.5, p \u2009<\u20090.005). In these patients, BAFF Index but not CSF CXCL13 levels inversely correlated with the intrathecal IgG synthesis ( r \u2009>\u20090.5 and p \u2009<\u20090.05 for all correlations). CSF leukocyte counts were significantly higher in IgGOB+ compared to IgGOB\u2212 ( p \u2009<\u20090.05) and HC ( p \u2009<\u20090.01), and correlated to CSF CXCL13 concentrations ( r 0.77, p \u2009<\u20090.001).
The gCTh was significantly lower in patients with higher CSF CXCL13 levels (2.41\u2009\ub1\u20090.1 vs 2.49\u2009\ub1\u20090.1\ua0mm, p \u2009<\u20090.05), while no difference in MRI parameters of WM and GM pathology was observed between IgGOB+ and IgGOB\u2212.
Conclusions
The intrathecal IgG synthesis inversely correlated with BAFF Index and showed no correlation with CSF CXCL13. These findings seem to indicate that intrathecally synthesized IgG are produced by long-term PCs that have entered the CNS from the peripheral blood, rather than produced by PCs developed in the meningeal follicle-like structures (FLS). In this study, CXCL13 identifies a subgroup of MS patients characterized by ..
Anisotropy and Ising-like transition of the S=5/2 two-dimensional Heisenberg antiferromagnet Mn-formate di-Urea
Recently reported measurements of specific heat on the compound Mn-formate
di-Urea (Mn-f-2U) by Takeda et al. [Phys. Rev. B 63, 024425 (2001)] are
considered. As a model to describe the overall thermodynamic behavior of such
compound, the easy-axis two-dimensional Heisenberg antiferromagnet is proposed
and studied by means of the 'pure quantum self-consistent harmonic
approximation' (PQSCHA). In particular it is shown that, when the temperature
decreases, the compound exhibits a crossover from 2D-Heisenberg to 2D-Ising
behavior, followed by a 2D-Ising-like phase transition, whose location allows
to get a reliable estimate of the easy-axis anisotropy driving the transition
itself. Below the critical temperature T_N=3.77 K, the specific heat is well
described by the two-dimensional easy-axis model down to a temperature T*=1.47
K where a T^3-law sets in, possibly marking a low-temperature crossover of
magnetic fluctuations from two to three dimensions.Comment: 3 pages, 2 figures, 47th Annual Conference on Magnetism and Magnetic
Materials (Tampa, FL, USA, 11-15/11/2002
Exploring complex networks via topological embedding on surfaces
We demonstrate that graphs embedded on surfaces are a powerful and practical
tool to generate, characterize and simulate networks with a broad range of
properties. Remarkably, the study of topologically embedded graphs is
non-restrictive because any network can be embedded on a surface with
sufficiently high genus. The local properties of the network are affected by
the surface genus which, for example, produces significant changes in the
degree distribution and in the clustering coefficient. The global properties of
the graph are also strongly affected by the surface genus which is constraining
the degree of interwoveness, changing the scaling properties from
large-world-kind (small genus) to small- and ultra-small-world-kind (large
genus). Two elementary moves allow the exploration of all networks embeddable
on a given surface and naturally introduce a tool to develop a statistical
mechanics description. Within such a framework, we study the properties of
topologically-embedded graphs at high and low `temperatures' observing the
formation of increasingly regular structures by cooling the system. We show
that the cooling dynamics is strongly affected by the surface genus with the
manifestation of a glassy-like freezing transitions occurring when the amount
of topological disorder is low.Comment: 18 pages, 7 figure
Heisenberg antiferromagnet on the square lattice for S>=1
Theoretical predictions of a semiclassical method - the pure-quantum
self-consistent harmonic approximation - for the correlation length and
staggered susceptibility of the Heisenberg antiferromagnet on the square
lattice (2DQHAF) agree very well with recent quantum Monte Carlo data for S=1,
as well as with experimental data for the S=5/2 compounds Rb2MnF4 and KFeF4.
The theory is parameter-free and can be used to estimate the exchange coupling:
for KFeF4 we find J=2.33 +- 0.33 meV, matching with previous determinations. On
this basis, the adequacy of the quantum nonlinear sigma model approach in
describing the 2DQHAF when S>=1 is discussed.Comment: 4 pages RevTeX file with 5 figures included by psfi
Kinetic energy of solid neon by Monte Carlo with improved Trotter- and finite-size extrapolation
The kinetic energy of solid neon is calculated by a path-integral Monte Carlo
approach with a refined Trotter- and finite-size extrapolation. These accurate
data present significant quantum effects up to temperature T=20 K. They confirm
previous simulations and are consistent with recent experiments.Comment: Text and figures revised for minor corrections (4 pages, 3 figures
included by psfig
Quantum fluctuations in one-dimensional arrays of condensates
The effects of quantum and thermal fluctuations upon the fringe structure
predicted to be observable in the momentum distribution of coupled
Bose-Einstein condensates are studied by the effective-potential method. For a
double-well trap, the coherence factor recently introduced by Pitaevskii and
Stringari [Phys. Rev. Lett. 87, 180402 (2001)] is calculated using the
effective potential approach and is found in good agreement with their result.
The calculations are extended to the case of a one-dimensional array of
condensates, showing that quantum effects are essentially described through a
simple renormalization of the energy scale in the classical analytical
expression for the fringe structure. The consequences for the experimental
observability are discussed.Comment: RevTeX, 4 pages, 5 eps figures (published version with updated
references
Spectral curves of surface reflectance in some antarctic regions
Four surface reflectance models of solar radiation were determined by examining several sets of field measurements taken for clear-sky conditions at various sites in Antarctica. Each model consists of the mean spectral curve of surface reflectance in the 0.25–2.7 μm wavelength range and of the dependence curve of total albedo on the solar elevation angle h, within the range from 5◦ to 55◦. The TNB (Terra Nova Bay) model refers to a rocky terrain where granites are predominant; the NIS (Nansen Ice Sheet) model to a glacier surface made uneven by sastrugi and streaked by irregular fractures; the HAP (High Altitude Plateau)
model to a flat ice surface covered by fresh snow and scored by light sastrugi; and the RIS (Ross Ice Shelf) model to an area covered by the sea ice pack presenting
many discontinuities in the reflectance features, due to melt water lakes, puddles, refrozen ice and snow pots. The reflectance curve obtained for the TNB model presents
gradually increasing values as wavelength increases through the visible spectral range and almost constant values at infrared wavelengths, giving a total albedo value equal
to 0.264 at h = 30◦, which increases by about 80% through the lower range of h and decreases by 12% through the upper range. The reflectance curves of the NIS, HAP and RIS models are all peaked at visible wavelengths and exhibit decreasing values throughout the infrared spectral range, giving values of total albedo equal to 0.464, 0.738 and 0.426 at h = 30◦, respectively. These values were estimated to increase by 8–14% as h decreases from 30◦ to 5◦ and to decrease by 2–4% only as h increases from 30◦ to 55◦
T Cell LFA-1 Engagement Induces HuR-Dependent Cytokine mRNA Stabilization through a Vav-1, Rac1/2, p38MAPK and MKK3 Signaling Cascade
Engagement of the β2 integrin, lymphocyte function-associated antigen-1 (LFA-1), results in stabilization of T cell mRNA transcripts containing AU-rich elements (AREs) by inducing rapid nuclear-to-cytosolic translocation of the RNA-stabilizing protein, HuR. However, little is known regarding integrin-induced signaling cascades that affect mRNA catabolism. This study examines the role of the GTPases, Rac 1 and Rac 2, and their downstream effectors, in the LFA-1-induced effects on mRNA.Engagement of LFA-1 to its ligand, ICAM-1, in human peripheral T cells resulted in rapid activation of Rac1 and Rac2. siRNA-mediated knockdown of either Rac1 or Rac2 prevented LFA-1-stimulated stabilization of the labile transcripts encoding IFN-γ and TNF-α, and integrin mediated IFN-γ mRNA stabilization was absent in T cells obtained from Rac2 gene-deleted mice. LFA-1 engagement-induced translocation of HuR and stabilization of TNF- α mRNA was lost in Jurkat cells deficient in the Rac guanine nucleotide exchange factor Vav-1 (J.Vav1). The transfection of J.Vav1 cells with constitutively active Rac1 or Rac2 stabilized a labile β-globin reporter mRNA, in a HuR-dependent manner. Furthermore, LFA-1-mediated mRNA stabilization and HuR translocation in mouse splenic T cells was dependent on the phosphorylation of the mitogen-activated protein kinase kinase, MKK3, and its target MAP kinase p38MAPK, and lost in T cells obtained from MKK3 gene-deleted mice.Collectively, these results demonstrate that LFA-1-induced stabilization of ARE-containing mRNAs in T cells is dependent on HuR, and occurs through the Vav-1, Rac1/2, MKK3 and p38MAPK signaling cascade. This pathway constitutes a molecular switch that enhances immune and pro-inflammatory gene expression in T cells undergoing adhesion at sites of activation and effector function
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