Gating Input to Visual Cortex by Feedback to LGN

Anatomical studies have documented massive back-projections from higher to lower visual cortices and to the lateral geniculate nucleus (LGN). The large number of synapses from these sources suggest that they should have a profound influence on the information carried by feed-forward inputs to these cells. However, the functional role of these connections is unclear. In order to explore the role of the feedback connections, we have recorded spike trains from electrodes placed in LGN in the macaque monkey under sufenta anesthesia, and have compared LGN cells' activity with and without suppression by cooling of feedback from primary visual cortex (V1). Normally, magno and parvo LGN cells show a wide range over which their responses are proportional to stimulus contrast. Inactivation of V1 feedback causes LGN cells to become more nonlinear and less sensitive to high contrast than during normal conditions. Responses during V1 inactivation have a similar shape to those of retinal ganglion cells. We have also tested the properties of the so-called extended surround as they relate to cortical activity and to influences on responses to LGN stimulation. A model of this data suggests an interpretation in terms of two fnuctional components of feedback: a contrast-dependent component which dominates at high input contrast, and a constant baseline level of inhibitory feedback. We also show that the influence of the extended surround on the classical center mechanism is more complicated than a simple integration model.National Institutes of Health (EY-05156); Office of Naval Research (N00014-95-1-409

Dual time scales in simulated annealing of a two-dimensional Ising spin glass

We apply a generalized Kibble-Zurek out-of-equilibrium scaling ansatz to simulated annealing when approaching the spin-glass transition at temperature $T=0$ of the two-dimensional Ising model with random $J= \pm 1$ couplings. Analyzing the spin-glass order parameter and the excess energy as functions of the system size and the annealing velocity in Monte Carlo simulations with Metropolis dynamics, we find scaling where the energy relaxes slower than the spin-glass order parameter, i.e., there are two different dynamic exponents. The values of the exponents relating the relaxation time scales to the system length, $\tau \sim L^z$, are $z=8.28 \pm 0.03$ for the relaxation of the order parameter and $z=10.31 \pm 0.04$ for the energy relaxation. We argue that the behavior with dual time scales arises as a consequence of the entropy-driven ordering mechanism within droplet theory. We point out that the dynamic exponents found here for $T \to 0$ simulated annealing are different from the temperature-dependent equilibrium dynamic exponent $z_{\rm eq}(T)$, for which previous studies have found a divergent behavior; $z_{\rm eq}(T\to 0) \to \infty$. Thus, our study shows that, within Metropolis dynamics, it is easier to relax the system to one of its degenerate ground states than to migrate at low temperatures between regions of the configuration space surrounding different ground states. In a more general context of optimization, our study provides an example of robust dense-region solutions for which the excess energy (the conventional cost function) may not be the best measure of success.Comment: 13 pages, 16 figure

Threshold Determination for ARTMAP-FD Familiarity Discrimination

The ARTMAP-FD neural network performs both identification (placing test patterns in classes encountered during training) and familiarity discrimination (judging whether a test pattern belongs to any of the classes encountered during training). ARTMAP-FD quantifies the familiarity of a test pattern by computing a measure of the degree to which the pattern's components lie within the ranges of values of training patterns grouped in the same cluster. This familiarity measure is compared to a threshold which can be varied to generate a receiver operating characteristic (ROC) curve. Methods for selecting optimal values for the threshold are evaluated. The performance of validation-set methods is compared with that of methods which track the development of the network's discrimination capability during training. The techniques are applied to databases of simulated radar range profiles.Advanced Research Projects Agency; Office of Naval Research (N00011-95-1-0657, N00011-95-0109, NOOOB-96-0659); National Science Foundation (IRI-94-01659

Calculation of the Two-body T-matrix in Configuration Space

A spectral integral method (IEM) for solving the two-body Schroedinger equation in configuration space is generalized to the calculation of the corresponding T-matrix. It is found that the desirable features of the IEM, such as the economy of mesh-points for a given required accuracy, are carried over also to the solution of the T-matrix. However the algorithm is considerably more complex, because the T-matrix is a function of two variables r and r', rather than only one variable r, and has a slope discontinuity at r=r'. For a simple exponential potential an accuracy of 7 significant figures is achieved, with the number N of Chebyshev support points in each partition equal to 17. For a potential with a large repulsive core, such as the potential between two He atoms, the accuracy decreases to 4 significant figures, but is restored to 7 if N is increased to 65.Comment: 22 pages, 1 table 8 figure

Related Services for Vermont\u27s Students with Disabilities

The purpose of Related Services for Vermont’s Students with Disabilities is to offer information regarding related services that is consistent with IDEA and with Vermont Law and regulations. It also describes promising or exemplary practices in education, special education, and related services. The manual’s content applies to all related services disciplines which serve students with disabilities, ages 3 through 21, who have an Individualized Education Program (IEP)

Buffered Reset Leads to Improved Compression in Fuzzy ARTMAP Classification of Radar Range Profiles

Fuzzy ARTMAP has to date been applied to a variety of automatic target recognition tasks, including radar range profile classification. In simulations of this task, it has demonstrated significant compression compared to k-nearest-neighbor classifiers. During supervised learning, match tracking search allocates memory based on the degree of similarity between newly encountered and previously encountered inputs, regardless of their prior predictive success. Here we invesetigate techniques that buffer reset based on a category's previous predictive success and thereby substantially improve the compression achieved with minimal loss of accuracy.Office of Naval Research (N00014-95-1-0657, N00014-95-1-0409, N00014-96-1-0659

Helium Recombination Lines as a Probe of Abundance and Temperature Problems

The paper presents a simplified formula to determine an electron temperature, Te(He I), for planetary nebulae (PNe) using the He I 7281/6678 line flux ratio. In our previous studies of Te(He I) (Zhang et al. 2005), we used the He I line emission coefficients given by Benjamin et al. (1999). Here we examine the results of using more recent atomic data presented by Porter et al. (2005). A good agreement is shown, suggesting that the effect of uncertainties of atomic data on the resultant Te(He I) is negligible. We also present an analytical formula to derive electron temperature using the He I discontinuity at 3421 A. Our analysis shows that Te(He I) values are significantly lower than electron temperatures deduced from the Balmer jump of H I recombination spectra, Te(H I), and that inferred from the collisionally excited [O III] nebular-to-auroral forbidden line flux ratio, Te([O III]). In addition, Te(H I) covers a wider range of values than either Te(He I) or Te([O III]). This supports the two-abundance nebular model with hydrogen-deficient material embedded in diffuse gas of a ``normal'' chemical composition (i.e. ~solar).Comment: 5 pages, 3 figures. To appear in the RevMexAA proceedings of "The Ninth Texas-Mexico Conference on Astrophysics

Dynamic scaling in the 2D Ising spin glass with Gaussian couplings

We carry out simulated annealing and employ a generalized Kibble-Zurek scaling hypothesis to study the 2D Ising spin glass with normal-distributed couplings. The system has an equilibrium glass transition at temperature $T=0$. From a scaling analysis when $T\rightarrow 0$ at different annealing velocities, we extract the dynamic critical exponent $z$, i.e., the exponent relating the relaxation time $\tau$ to the system length $L$; $\tau\sim L^z$. We find $z=13.6 \pm 0.4$ for both the Edwards-Anderson spin-glass order parameter and the excess energy. This is different from a previous study of the system with bimodal couplings [S. J. Rubin, N. Xu, and A. W. Sandvik, Phys. Rev. E {\bf 95}, 052133 (2017)] where the dynamics is faster and the above two quantities relax with different exponents (and that of the energy is larger). We here argue that the different behaviors arise as a consequence of the different low-energy landscapes---for normal-distributed couplings the ground state is unique (up to a spin reflection) while the system with bimodal couplings is massively degenerate. Our results reinforce the conclusion of anomalous entropy-driven relaxation behavior in the bimodal Ising glass. In the case of a continuous coupling distribution, our results presented here indicate that, although Kibble-Zurek scaling holds, the perturbative behavior normally applying in the slow limit breaks down, likely due to quasi-degenerate states, and the scaling function takes a different form.Comment: 10 pages, 5 figure

False-negative upper extremity ultrasound in the initial evaluation of patients with suspected subclavian vein thrombosis due to thoracic outlet syndrome (Paget-Schroetter syndrome)

OBJECTIVE: To assess the utilization and consequences of upper extremity Duplex ultrasound in the initial diagnostic evaluation of patients with suspected subclavian vein (SCV) thrombosis and venous thoracic outlet syndrome (VTOS). METHODS: A retrospective single-center review was conducted for patients that underwent primary surgical treatment for VTOS between 2008 and 2017, in whom an upper extremity ultrasound had been performed as the initial diagnostic test (n = 214). Clinical and treatment characteristics were compared between patients with positive and false-negative ultrasound studies. RESULTS: There were 122 men (57%) and 92 women (43%) that had presented with spontaneous idiopathic arm swelling, including 28 (13%) with proven pulmonary embolism, at a mean age of 30.7 ± 0.8 years (range 14-69). Upper extremity ultrasound had been performed 23.8 ± 12.2 days after the onset of symptoms, with confirmation of axillary-SCV thrombosis in 169 patients (79%) and negative results in 45 (21%). Of the false-negative ultrasound study reports, only 8 (18%) acknowledged limitations in visualizing the central SCV. Definitive diagnostic imaging (DDI) had been obtained by upper extremity venography in 175 (82%), computed tomography angiography in 24 (11%), and magnetic resonance angiography in 15 (7%), with 142 (66%) undergoing catheter-directed axillary-SCV thrombolysis. The mean interval between initial ultrasound and DDI was 48.9 ± 14.2 days with no significant difference between groups, but patients with a positive ultrasound were more likely to have DDI within 48 hours than those with a false-negative ultrasound (44% vs 24%; P = .02). At the time of surgical treatment, the SCV was widely patent following paraclavicular decompression and external venolysis alone in 74 patients (35%). Patch angioplasty was performed for focal SCV stenosis in 76 (36%) and bypass graft reconstruction for long-segment axillary-SCV occlusion in 63 (29%). Patients with false-negative initial ultrasound studies were significantly more likely to require SCV bypass reconstruction than those with a positive ultrasound (44% vs 25%; P = .02). CONCLUSIONS: Duplex ultrasound has significant limitations in the initial evaluation of patients with suspected SCV thrombosis, with false-negative results in 21% of patients with proven VTOS. This is rarely acknowledged in ultrasound reports, but false-negative ultrasound studies have the potential to delay definitive imaging, thrombolysis, and further treatment for VTOS. Initial false-negative ultrasound results are associated with progressive thrombus extension and a more frequent need for SCV bypass reconstruction at the time of surgical treatment