1 research outputs found
Natural polyphenolic coffee extract administration relieves chronic nociplastic pain in a reserpineâinduced fibromyalgiaâlike female mouse model
Abstract Introduction Nociplastic pain involves reflexive and nonreflexive pain responses and it is a core symptom of fibromyalgia (FM). The increasing prevalence of this health condition and the low rates of patientsâ quality of life, combined with the lack of suitable pharmacologic treatments, evidence the demand to research new alternatives. Polyphenols may be potential therapeutic candidates as they have been reported to exert pathological pain modulation in preclinical models. In that context, this work was aimed to study the antinociceptive effects of a polyphenolic extract obtained from decaffeinated ground roasted coffee, in the RIM6 FMâlike mouse model. Methods To this end, RIM6 adult ICRâCD1 female mice were administered daily once a week with either 10 or 15Â mg/kg of extract, and reflexive pain responses were evaluated for up to 3 weeks. At the end, the depressiveâlike behavior was assessed as a nonreflexive pain response, and spinal cord and serum samples were collected for immunohistochemical and toxicological analyses. Results These findings showed that the repeated administration of the coffee polyphenolic extract (CE) modulated reflexive pain responses, depressiveâlike behavior, and spinal cord gliosis in a doseâdependent manner, without signs of systemic toxicity. Conclusion Thus, the CE may be a potential pharmacological treatment suitable to relieve nociplastic pain responses characteristic of FM