4 research outputs found
CRP Levels as a Prognostic Factor in Mycosis Fungoides
Mycosis Fungoides (MF) and SĂ©zary syndrome (SS) are the most com-
mon forms of cutaneous T-cell lymphomas. Few validated prognostic factors have
been reported in MF/SS, especially when compared with non-cutaneous lympho-
mas. Increased C-reactive protein (CRP) levels have recently been associated with
poor clinical outcome in various malignancies. The aim of this study was to evaluate
the prognostic significance of serum CRP levels at diagnosis in patients with MF/
SS. This retrospective study included 76 patients with MF/SS. Stage was assigned
according to the ISCL/EORTC guidelines. The follow-up period was 24 months or
more. Disease course and response to treatment were determined using quantita-
tive scales. Wilcoxon’s rank test and multivariate regression analysis were used to
analyze the data. Increased CRP levels correlated significantly with advanced stages
(Wilcoxon’s test, P>0.0001). Furthermore, increased CRP levels were associated with
a lower treatment response rate (Wilcoxon’s test, P=0.0012). Multivariate regression
analysis showed that CRP is an independent predictor of advanced clinical stage at
diagnosis.The present data suggest that elevated CRP levels could serve as a useful
prognostic factor in MF/SS and may assist in guiding treatment choices
CRP Levels as a Prognostic Factor in Mycosis Fungoides
Mycosis Fungoides (MF) and SĂ©zary syndrome (SS) are the most com-
mon forms of cutaneous T-cell lymphomas. Few validated prognostic factors have
been reported in MF/SS, especially when compared with non-cutaneous lympho-
mas. Increased C-reactive protein (CRP) levels have recently been associated with
poor clinical outcome in various malignancies. The aim of this study was to evaluate
the prognostic significance of serum CRP levels at diagnosis in patients with MF/
SS. This retrospective study included 76 patients with MF/SS. Stage was assigned
according to the ISCL/EORTC guidelines. The follow-up period was 24 months or
more. Disease course and response to treatment were determined using quantita-
tive scales. Wilcoxon’s rank test and multivariate regression analysis were used to
analyze the data. Increased CRP levels correlated significantly with advanced stages
(Wilcoxon’s test, P>0.0001). Furthermore, increased CRP levels were associated with
a lower treatment response rate (Wilcoxon’s test, P=0.0012). Multivariate regression
analysis showed that CRP is an independent predictor of advanced clinical stage at
diagnosis.The present data suggest that elevated CRP levels could serve as a useful
prognostic factor in MF/SS and may assist in guiding treatment choices
FOXP3 Predicts Response to Treatment in Mycosis Fungoid
Background: The role of the T-regulatory cells (Tregs) marker forkhead box Protein
3 (FOXP3) in mycoses fungoides (MF) pathogenesis is unclear and the results of
previous studies are inconclusive.
Objective: We aimed at ascertaining the possibility that FOXP3 expression may
serve to predict MF stage and response to therapy.
Patients and methods: Immunohistochemistry staining for FOXP3 was performed
on 30 skin biopsies from patients with MF, and FOXP3 expression level was quantitatively
graded. Disease stage, progression, and response to treatment were determined
based on clinical and imaging evidence, and association with FOXP3 expression
was assessed.
Results: FOXP3 expression in the dermis correlated with poor response to treatment
(P=0.047). A negative non-significant relationship between epidermal FOXP3
expression and clinical stage severity was observed (P=0.17).
Conclusions: Dermal FOXP3 expression in MF lesions could be used to predict response
to treatment in patients with MF
FOXP3 Predicts Response to Treatment in Mycosis Fungoid
Background: The role of the T-regulatory cells (Tregs) marker forkhead box Protein
3 (FOXP3) in mycoses fungoides (MF) pathogenesis is unclear and the results of
previous studies are inconclusive.
Objective: We aimed at ascertaining the possibility that FOXP3 expression may
serve to predict MF stage and response to therapy.
Patients and methods: Immunohistochemistry staining for FOXP3 was performed
on 30 skin biopsies from patients with MF, and FOXP3 expression level was quantitatively
graded. Disease stage, progression, and response to treatment were determined
based on clinical and imaging evidence, and association with FOXP3 expression
was assessed.
Results: FOXP3 expression in the dermis correlated with poor response to treatment
(P=0.047). A negative non-significant relationship between epidermal FOXP3
expression and clinical stage severity was observed (P=0.17).
Conclusions: Dermal FOXP3 expression in MF lesions could be used to predict response
to treatment in patients with MF