Crossing boundaries:bras, lingerie and rape myths in postcolonial urban middle-class India

With the processes of modernization, urbanization and the entry of women in the formal labour market in Indian metropolitan spaces, this paper examines how the modern middle-class woman’s sartorial choices become enmeshed in popular rape myths (false beliefs) that serve to blame her for the wearing of western clothing. The paper articulates the ways in which middle-class women’s social realities are shaped by historical, colonial and nationalist ideologies of modernization, constructed and mediated through moral codes of dressing. By drawing upon original and contemporary empirical narratives from the urban spaces of Delhi and Mumbai, we emphasise how everyday sartorial choices, in relation to particularly the bra and lingerie, can reveal the nuanced ways in which Urban Indian Professional Women (UIPW) seek to understand, negotiate, and resist patriarchal power. Our findings shed light on conflicting and contradictory spatial experiences, where some women internalize and negotiate moral codes of dressing, out of fear, and others who transgress are subject to sanctions. Given the paucity of scholarly literature in this area, the paper makes an important theoretical and empirical contribution with its focus on postcoloniality and everyday discursive material spaces of gendered and sexualized dress practices. It argues for the consciousness raising of everyday urban geographies of dress that reveal complicated structures of power that are often deemed hidden

Prediction of novel miRNA biomarker candidates for diagnostic and prognostic analysis of STAD and LIHC: An integrated in silico approach

Background: miRNAs are endogenous, non-coding and evolutionarily conserved RNA molecules. They have been found to be involved in the progression and proliferation of various cancers due to their contribution in post-transcriptional regulation. Stomach Adenocarcinoma (STAD) and Liver Hepatocellular Carcinoma (LIHC) are the two most common cancers of the upper intestinal tract. Our study aimed to evaluate the circulating miRNAs from both STAD and LIHC samples and to identify commonly dysregulated miRNAs as biomarkers to detect both cancers at the same time. Methods and materials: Common differentially expressed miRNAs (DEMs) from GEO and Bioexpress datasets were considered for initial processing in the analysis. Pathway analysis of the selected miRNAs through DIANA-miRpath tool, followed by survival analysis based on prognostic values through OncoLnc server led to the final biomarker candidates for diagnosis and prognosis of STAD and LIHC. An elaborate miRNA-gene-cancer network was set up for a specialized understanding of the selected DEMs corresponding to the specifically unique target genes and the cancer types. The gene ontology analysis was performed using BINGO to determine functional connotations of the differentially expressed genes (DEGs). Results: After a thorough analysis, we found that the 4 miRNAs: miR-183-5p, miR-203-3p, miR-126-3p and miR-25-3p could be potential prognostic biomarkers against both STAD and LIHC. The differentially expressed genes (DEGs) for these miRNAs were inferred through GEPIA and miRwalk v2.0. The miRNA-gene-cancer network revealed that the commonly deregulated miRNAs could influence the same genes and pathways altered by multiple cancers at the same time-in our case, STAD and LIHC. To support our claim, we showed the gene ontology analysis by BINGO, attesting the functional assignment of the DEGs behind metastasis and development of both the cancers. Conclusion: Our study evaluated a particularly effective avenue of identifying novel miRNA for both early diagnostic and prognostic purposes against more than one cancer

"Where is the time to sleep?" Orientalism and citizenship in Mahasweta Devi’s writing

This article discusses the close relationship between Bengali writer Mahasweta Devi’s literary work and her activism in support of indigenous people in India, and considers the two activities as interventions in the field of law. Devi’s emphasis on the continuity between colonial and postcolonial legal frameworks invites us to look at law as a governing discourse that stigmatized Adivasis. The criminalization of indigenous people via the Criminal Tribes Act (1871) and the presumption that they belonged to a “state of nature” form part of an orientalist bias against the tribals that was legally sustained during colonialism and also through Nehru’s discourses on the modern nation. Through analysis of the short story “Operation? – Bashai Tudu”, where law appears as a non-democratic instrument for governing the poor, and using extracts from a hitherto unpublished conversation between the author and Devi, it argues that Devi’s work can be considered as a crucial analytical tool with which to explore the genealogy of Adivasi marginalization

Cosmopolitismes en Asie du Sud

Le cosmopolitisme est-il un enfant de la modernité occidentale ou peut-on le trouver en d’autres temps et d’autres lieux ? Cet ouvrage entend apporter une réponse à cette question aujourd’hui vivement débattue en retraçant ses contours en tant que pratique et Weltanschauung dans une région du monde - l’Asie du Sud - pôle majeur de l’espace de circulation de l’Asie musulmane et nœud des flux humains, matériels et immatériels reliant l’Occident à l’Orient au cours des XVIe-XVIIIe siècles. Terre d’accueil pour de nombreuses élites en quête de patronage, port d’ancrage pour d’autres ou encore simple étape au sein de parcours transocéaniques guidés par l’appétit de richesses ou de savoirs, l’Asie du Sud de la première modernité est un terreau particulièrement fertile pour la construction d’identités et de visions cosmopolites, tant au niveau individuel qu’à celui de la polis. Aussi hétérogène comme idée que comme habitus, le cosmopolitisme est abordé ici sous un angle résolument pluriel favorisant la multiplication des approches (acteurs, langues, lieux, activités à « vocation » cosmopolite) et le croisement de ses différentes manifestations - moghole, marathe, européennes, etc. - afin d’en faire mieux ressortir les constantes, variantes, limites et interactions. Dans cette optique, les études réunies au fil de ce numéro illustrent bel et bien ce que le « citoyen du monde » des Lumières doit aux « Indes orientales »

A defective oxidative burst and impaired antigen presentation are hallmarks of human visceral leishmaniasis

Purpose: Survival of the Leishmania parasite within monocytes hinges on its ability to effectively nullify their microbicidal effector mechanisms. Accordingly, this study aimed to delineate this biological niche in patients with visceral leishmaniasis (VL). Methods: In monocytes, the redox status, antigen presenting capacity, expression of Toll-like receptors (TLRs), co-stimulatory molecules (CD80/86) and generation of intracellular cytokines (IL-8, IL-1β, IL-10 and LAP-TGF-β1) was measured by flow cytometry, levels of circulating cytokines (IL-1β, IL-6, TNF-α, IL-8, IL-4, IL-13, IL-10 and GM-CSF) by ELISA and arginase activity by spectrophotometry. Results: Within monocytes, generation of an oxidative burst was markedly attenuated as evident by decreased generation of nitric oxide and reactive oxygen species, concomitant with raised levels of thiols. This was accompanied by lowered frequency of TLR₄⁺ monocytes, but the arginase activity remained unaltered. Pathogen persistence was enhanced by the predominance of anti-inflammatory cytokines within monocytes, notably IL-10. Alongside, development of adaptive immunity was severely attenuated as manifested by a pronounced impairment of antigen presentation and co-stimulation evident by down regulation of CD₅₄, HLA-DR and CD86. Treatment corrected the redox imbalance and reversed the impaired antigen presentation. Conclusions: In VL, monocyte functions were severely impaired facilitating parasite persistence; anti-leishmanial chemotherapy mediated parasite elimination through modulation of the macrophage microenvironment by restoring its redox status and antigen presenting capacity