Palaeomagnetic constraints on the evolution of the Caledonian-Appalachian orogen

Late Proterozoic and Palaeozoic (pre-Permian) palaeomagnetic data from all regions involved in, or adjacent to, the Caledonian-Appalachian orogenic belt are reviewed. Between about 1100 and about 800 Ma the Laurentian and Baltic shields were close together, prior to the opening phase of the Caledonian-Appalachian Wilson cycle. The problems of tectonic interpretation of Palaeozoic palaeomagnetic data from within and around the belt derive mostly from differences of typically 10°-20° between the pole positions. These can variously be interpreted in terms of (i) relative displacements between different continents or terranes, (ii) differences in ages of remanence and (iii) aberrations due to inadequacy of data or geomagnetic complexity, and it is not always easy to discriminate between these alternatives. If the Pangaea A2 reassembly of continents around the northern and central Atlantic is taken as the end-product of Caledonian-Appalachian orogenesis, the following conclusions can be drawn: 1. Lower Palaeozoic palaeolatitude differences between the N American and British-Scandinavian margins of the Caledonides are small; hence any convergence must have been mainly E-W. 2. There are additional differences which could be due to major pre-Carboniferous strike-slip (more than 1000 km), although later strike-slip on this scale is no longer considered likely. 3. The Lower Palaeozoic apparent polar wander paths for Northern Scotland and N America disagree on face value, but must be reconciled if their conventionally assumed geographic relation is correct. 4. Lower Old Red Sandstone data from Britain and Norway disagree, but this is more likely to be due to magnetic overprinting in the Norwegian rocks than to remnant oceans between the regions of Old Red Sandstone facies. 5. Armorica seems to have been far to the S, adjacent to Gondwana, in Ordovician time. The latest view is that it collided with Euramerica in early Devonian time to form the Old Red Continent. 6. The timing of Gondwana's collision with the Old Red Continent is controversial; it is within either the late Devonian or the Carboniferous. If it occurred early in that time range, much of Hercynian-Alleghanian orogeny post-dated it

Exploring the oral microbiota of children at various developmental stages of their dentition in the relation to their oral health

<p>Abstract</p> <p>Background</p> <p>An understanding of the relation of commensal microbiota to health is essential in preventing disease. Here we studied the oral microbial composition of children (N = 74, aged 3 - 18 years) in natural transition from their deciduous to a permanent dentition and related the microbial profiles to their oral health status. The microbial composition of saliva was assessed by barcoded pyrosequencing of the V5-V6 hypervariable regions of the 16 S rRNA, as well as by using phylogenetic microarrays.</p> <p>Results</p> <p>Pyrosequencing reads (126174 reads, 1045 unique sequences) represented 8 phyla and 113 higher taxa in saliva samples. Four phyla - Firmicutes, Bacteriodetes, Proteobacteria and Actinobacteria - predominated in all groups. The deciduous dentition harboured a higher proportion of Proteobacteria (Gammaproteobacteria, Moraxellaceae) than Bacteroidetes, while in all other groups Bacteroidetes were at least as abundant as Proteobacteria. Bacteroidetes (mainly genus <it>Prevotella</it>), Veillonellaceae family, Spirochaetes and candidate division TM7 increased with increasing age, reflecting maturation of the microbiome driven by biological changes with age.</p> <p>Microarray analysis enabled further analysis of the individual salivary microbiota. Of 350 microarray probes, 156 gave a positive signal with, on average, 77 (range 48-93) probes per individual sample.</p> <p>A caries-free oral status significantly associated with the higher signal of the probes targeting <it>Porphyromonas catoniae </it>and <it>Neisseria flavescens</it>.</p> <p>Conclusions</p> <p>The potential role of <it>P. catoniae </it>and <it>N. flavescens </it>as oral health markers should be assessed in large-scale clinical studies. The combination of both, open-ended and targeted molecular approaches provides us with information that will increase our understanding of the interplay between the human host and its microbiome.</p

Morphological and geological features of Drake Passage, Antarctica, from a new digital bathymetric model

The Drake Passage is an oceanic gateway of about 850 km width located between South America and the Antarctic Peninsula that connects the southeastern Pacific Ocean with the southwestern Atlantic Ocean. It is an important gateway for mantle flow, oceanographic water masses, and migrations of biota. This sector developed within the framework of the geodynamic evolution of the Scotia Arc, including continental fragmentation processes and oceanic crust creation, since the oblique divergence of the South American plate to the north and the Antarctic plate to the south started in the Eocene. As a consequence of its complex tectonic evolution and subsequent submarine processes, as sedimentary infill and erosion mainly controlled by bottom currents and active tectonics, this region shows a varied physiography. We present a detailed map of the bathymetry and geological setting of the Drake Passage that is mainly founded on a new compilation of precise multibeam bathymetric data obtained on 120 cruises between 1992 and 2015, resulting in a new Digital Bathymetric Model with 200 × 200 m cell spacing. The map covers an area of 1,465,000 km2 between parallels 52°S and 63°S and meridians 70°W and 50°W at scale 1:1,600,000 allowing the identification of the main seafloor features. In addition, the map includes useful geological information related to magnetism, seismicity and tectonics. This work constitutes an international cooperative effort and is part of the International Bathymetric Chart of the Southern Ocean project, under the Scientific Committee on Antarctic Research umbrella

Ertapenem versus piperacillin/tazobactam for the treatment of complicated infections: a meta-analysis of randomized controlled trials

<p>Abstract</p> <p>Background</p> <p>Ertapenem, a new carbapenem with a favorable pharmacokinetic profile, has been approved for the treatment of complicated intra-abdominal Infections (cIAIs), acute pelvic infections (APIs) and complicated skin and skin-structure infections (cSSSIs). The aim of this study is to compare the efficacy and safety of ertapenem with piperacillin/tazobactam, which has been reported to possess good efficacy for the treatment of these complicated infections.</p> <p>Methods</p> <p>We performed a meta-analysis of randomized controlled trials identified in PubMed, Cochrane library and Embase that compared the efficacy and safety of ertapenem with piperacillin/tazobactam for the treatment of complicated infections including cIAIs, APIs, cSSSIs. The primary efficacy outcome was clinical treatment success assessed at the test-of-cure visit. The primary safety outcome was drug related clinical and laboratory adverse events occurred during the treatment and the post-treatment period.</p> <p>Result</p> <p>Six RCTs, involving 3161 patients, were included in our meta-analysis. Ertapenem was associated similar clinical treatment success with piperacillin/tazobactam for complicated infections treatment (clinically evaluable population, 1937 patients, odds ratios: 1.15, 95% confidence intervals: 0.89-1.49; modified intention to treat population, 2855 patients, odds ratios: 1.03, 95% confidence intervals: 0.87-1.22). All of secondary efficacy outcomes analysis obtained similar findings with clinical treatment success. No difference was found about the incidence of drug related adverse events between ertapenem and piperacillin/tazobactam groups.</p> <p>Conclusion</p> <p>This meta-analysis provides evidence that ertapenem 1 g once a day can be used as effectively and safely as recommended dose of piperacillin/tazobactam, for the treatment of complicated infections, particularly of mild to moderate severity. It is an appealing option for the treatment of these complicated infections.</p

Innovative solar thermochemical water splitting.

Sandia National Laboratories (SNL) is evaluating the potential of an innovative approach for splitting water into hydrogen and oxygen using two-step thermochemical cycles. Thermochemical cycles are heat engines that utilize high-temperature heat to produce chemical work. Like their mechanical work-producing counterparts, their efficiency depends on operating temperature and on the irreversibility of their internal processes. With this in mind, we have invented innovative design concepts for two-step solar-driven thermochemical heat engines based on iron oxide and iron oxide mixed with other metal oxides (ferrites). The design concepts utilize two sets of moving beds of ferrite reactant material in close proximity and moving in opposite directions to overcome a major impediment to achieving high efficiency--thermal recuperation between solids in efficient counter-current arrangements. They also provide inherent separation of the product hydrogen and oxygen and are an excellent match with high-concentration solar flux. However, they also impose unique requirements on the ferrite reactants and materials of construction as well as an understanding of the chemical and cycle thermodynamics. In this report the Counter-Rotating-Ring Receiver/Reactor/Recuperator (CR5) solar thermochemical heat engine and its basic operating principals are described. Preliminary thermal efficiency estimates are presented and discussed. Our ferrite reactant material development activities, thermodynamic studies, test results, and prototype hardware development are also presented

Genomic analysis and temperature-dependent transcriptome profiles of the rhizosphere originating strain Pseudomonas aeruginosa M18

<p>Abstract</p> <p>Background</p> <p>Our previously published reports have described an effective biocontrol agent named <it>Pseudomonas </it>sp. M18 as its 16S rDNA sequence and several regulator genes share homologous sequences with those of <it>P. aeruginosa</it>, but there are several unusual phenotypic features. This study aims to explore its strain specific genomic features and gene expression patterns at different temperatures.</p> <p>Results</p> <p>The complete M18 genome is composed of a single chromosome of 6,327,754 base pairs containing 5684 open reading frames. Seven genomic islands, including two novel prophages and five specific non-phage islands were identified besides the conserved <it>P. aeruginosa </it>core genome. Each prophage contains a putative chitinase coding gene, and the prophage II contains a <it>capB </it>gene encoding a putative cold stress protein. The non-phage genomic islands contain genes responsible for pyoluteorin biosynthesis, environmental substance degradation and type I and III restriction-modification systems. Compared with other <it>P. aeruginosa </it>strains, the fewest number (3) of insertion sequences and the most number (3) of clustered regularly interspaced short palindromic repeats in M18 genome may contribute to the relative genome stability. Although the M18 genome is most closely related to that of <it>P. aeruginosa </it>strain LESB58, the strain M18 is more susceptible to several antimicrobial agents and easier to be erased in a mouse acute lung infection model than the strain LESB58. The whole M18 transcriptomic analysis indicated that 10.6% of the expressed genes are temperature-dependent, with 22 genes up-regulated at 28°C in three non-phage genomic islands and one prophage but none at 37°C.</p> <p>Conclusions</p> <p>The <it>P. aeruginosa </it>strain M18 has evolved its specific genomic structures and temperature dependent expression patterns to meet the requirement of its fitness and competitiveness under selective pressures imposed on the strain in rhizosphere niche.</p

Electron cloud effects on an intense ion beam in a four solenoid lattice

The Solenoid Transport Experiment (STX) at LBNL successfully demonstrated the transport of a space-charge dominated ion beam in a two-solenoid lattice. Initial experiments showed a strong dependence of electron cloud effects on solenoid field strength. A current-reducing aperture, two solenoids and in-bore diagnostics were added to the two-solenoid lattice in order to study electron cloud effects more closely. Experiments were conducted with a 10 {micro}s, singly charged potassium ion bunch at an ion energy of 0.3 MeV and currents of 26 mA and 45 mA. A qualitative comparison of experimental and calculated results are presented, including a comparison of the effects of manipulating electrons on the beam dynamics, quantifying beam-induced gas desorption, ionization, and electron effects

A customised GIS to aid Gondwana research

Geographical information Systems (GIS) provide tools for manipulating and analysing the large thematic datasets associated with Gondwana research. We have used a customised version of Environmental Systems Research Institute's ArcGIS, version 8.2, as the basis of our 'Gondwana and Southern Ocean Computer Model' (GSCM). The additional functionality necessary for paleogeographic work was written in Visual Basic for Applications (VBA), and includes routines for assigning data to the relevant plates (Plate Sieving) and transformation from present to paleo-coordinates (Rotate Data). The sieving function employs a user-supplied plate network, so that the same data can be assigned to different plate systems at different scales. Paleo-coordinate transformations are handled entirely within ArcGIS, preserving the links to data attributes, and thereby permitting spatial analysis with continents in their former configuration. We give a detailed description of these functions, together with some simple examples of the system's capabilities using data to large igneous provinces

The present configuration of the Bouvet triple junction

New Hawaii-MR1 sonar data show that the southernmost Mid-Atlantic Ridge joins the South American–Antarctic Ridge by an obliquely opening rift and overlaps Spiess Ridge, the westernmost segment of the Southwest Indian Ridge, with no evidence for a transform fault. The junction is therefore neither ridge-fault-fault nor ridge-ridge-ridge. We speculate that growth of Spiess Ridge adjacent to the triple junction has caused this complexity and discuss more generally the origins of distributed deformation at oceanic triple junctions