A hybrid technique to address exposure keratopathy secondary to facial nerve paresis: A combination of a lateral tarsorrhaphy and lateral wedge resection

Purpose To present the results of treating combined lower eyelid laxity, retraction and midface descent secondary to facial nerve weakness with a hybrid surgical procedure. Materials and methods A retrospective analysis of patients from January 2015 to January 2017 who underwent a hybrid surgical technique for the treatment of corneal exposure secondary to facial nerve paresis with a single surgeon was performed. Age, gender, and presence of exposure symptoms were recorded pre-operatively. Outcomes assessed included improvement of lower eyelid laxity and position, operative complications, and post-operative symptomatic relief. Results A total of 11 patients underwent unilateral eyelid surgery. All patients had symptomatic relief and good functional outcomes defined as improvement in eyelid laxity, lower eyelid position, and objective corneal exposure. No cases required reoperation during an average follow up of 174.5 days. Conclusions Combining portions of a tarsorrhaphy and lateral wedge resection technique is a simple and effective procedure to improve lower eyelid position and limit corneal exposure secondary to facial nerve paresis

Mutant mice with rod-specific VPS35 deletion exhibit retinal α-synuclein pathology-associated degeneration.

Vacuolar protein sorting 35 (VPS35), the core component of the retromer complex which regulates endosomal trafficking, is genetically linked with Parkinson's disease (PD). Impaired vision is a common non-motor manifestation of PD. Here, we show mouse retinas with VPS35-deficient rods exhibit synapse loss and visual deficit, followed by progressive degeneration concomitant with the emergence of Lewy body-like inclusions and phospho-α-synuclein (P-αSyn) aggregation. Ultrastructural analyses reveal VPS35-deficient rods accumulate aggregates in late endosomes, deposited as lipofuscins bound to P-αSyn. Mechanistically, we uncover a protein network of VPS35 and its interaction with HSC70. VPS35 deficiency promotes sequestration of HSC70 and P-αSyn aggregation in late endosomes. Microglia which engulf lipofuscins and P-αSyn aggregates are activated, displaying autofluorescence, observed as bright dots in fundus imaging of live animals, coinciding with pathology onset and progression. The Rod∆Vps35 mouse line is a valuable tool for further mechanistic investigation of αSyn lesions and retinal degenerative diseases

Herschel-ATLAS and ALMA: HATLAS J142935.3-002836, a lensed major merger at redshift 1.027

Context. The submillimetre-bright galaxy population is believed to comprise, aside from local galaxies and radio-loud sources, intrinsically active star-forming galaxies, the brightest of which are lensed gravitationally. The latter enable studies at a level of detail beyond what is usually possible by the observation facility. Aims. This work focuses on one of these lensed systems, HATLAS J142935.3−002836 (H1429−0028), selected in the Herschel-ATLAS field. Gathering a rich, multi-wavelength dataset, we aim to confirm the lensing hypothesis and model the background source’s morphology and dynamics, as well as to provide a full physical characterisation. Methods. Multi-wavelength high-resolution data is utilised to assess the nature of the system. A lensing-analysis algorithm that simultaneously fits different wavebands is adopted to characterise the lens. The background galaxy dynamical information is studied by reconstructing the 3D source plane of the ALMA CO (J:4 → 3) transition. Near-IR imaging from HST and Keck-AO allows to constrain rest-frame optical photometry independently for the foreground and background systems. Physical parameters (such as stellar and dust masses) are estimated via modelling of the spectral energy distribution taking source blending, foreground obscuration, and differential magnification into account. Results. The system comprises a foreground edge-on disk galaxy (at zsp = 0.218) with an almost complete Einstein ring around it. The background source (at zsp = 1.027) is magnified by a factor of μ ~ 8−10 depending on wavelength. It is comprised of two components and a tens-of-kpc-long tidal tail resembling the Antennæ merger. As a whole, the background source is a massive stellar system (1.32-0.41+ 0.63 × 1011 M⊙) forming stars at a rate of 394 ± 90  M⊙ yr-1, and it has a significant gas reservoir MISM = 4.6 ± 1.7 × 1010 M⊙. Its depletion time due to star formation alone is thus expected to be τSF = MISM/ SFR = 117 ± 51 Myr. The dynamical mass of one of the components is estimated to be 5.8 ± 1.7 × 1010 M⊙, and, together with the photometric total mass estimate, it implies that H1429−0028 is a major merger system (1:2.8-1.5+1.8)

Problemas encontrados durante la traducción del francés hacia el español de la parte I y II de la «Guía Un Turismo Sostenible para el Desarrollo», realizada por los estudiantes de V año de Traducción e Interpretación de Lenguas Extranjeras periodo 2021-2022

La lingüística se reconoce como la disciplina que tiene por propósito la investigación, descripción y evolución de una lengua. En el contexto de la traducción esta disciplina es una herramienta esencial a considerar, puesto que, brinda una serie de explicaciones de los problemas que se presentan al momento de traducir un texto de una lengua a otra. Este trabajo se enfoca en analizar los problemas encontrados en la traducción de la primera y segunda parte de la «Guía Un Turismo Sostenible para el Desarrollo», en vista que gran parte de las dificultades de traducción presentadas en este documento se derivan de las lenguas español y francés, fue necesario hacer uso de la investigación documental en temas relacionados a la traductología, lingüística, turismo, administración y otros, a fin de resolver los problemas que se presentarán más adelante. Cabe destacar que este documento cuenta con particularidades propias que se ajustan a la modalidad Seminario de Graduación de la carrera, no obstante, de manera general la investigación se perfila bajo el método inductivo, de tipo transversal y con un enfoque cualitativo. En conclusión, el resultado de este trabajo proporciona una propuesta de traducción que será de beneficio para los estudiantes de la carrera de Turismo Sostenible y para las instituciones relacionadas a este sector, dado que, la guía permite el análisis y la evaluación de los proyectos de desarrollo que propone el sector turístico para crear un turismo amigable con el medio ambiente en el cual se involucran tanto el gobierno, las instituciones público-privadas como la comunidad, asimismo, esta propuesta de traducción garantizará un antecedente de la temática para los traductores en formació

Non-Standard Errors

In statistics, samples are drawn from a population in a data-generating process (DGP). Standard errors measure the uncertainty in estimates of population parameters. In science, evidence is generated to test hypotheses in an evidence-generating process (EGP). We claim that EGP variation across researchers adds uncertainty: Non-standard errors (NSEs). We study NSEs by letting 164 teams test the same hypotheses on the same data. NSEs turn out to be sizable, but smaller for better reproducible or higher rated research. Adding peer-review stages reduces NSEs. We further find that this type of uncertainty is underestimated by participants

Neurosarcoidosis Masquerading as Giant Cell Arteritis With Incidental Meningioma

We present a case of vision loss secondary to neurosarcoidosis, which initially presented with severe bilateral vision loss, temporal headaches, and elevated erythrocyte sedimentation rate, concerning for giant cell arteritis. However, temporal artery biopsy was negative. Initial neuroimaging features were misinterpreted to represent a meningioma that did not account for his clinical presentation. Clinical course, including atypically rapid enlargement of presumed meningioma, development of skin lesions, appearance of optic nerve enhancement on MRI, and steroid response, strongly increased suspicion for sarcoidosis. Biopsy of a skin lesion demonstrated noncaseating granulomatous inflammation, consistent with sarcoidosis

Components of the RNAi Machinery That Mediate Long-Distance Chromosomal Associations Are Dispensable for Meiotic and Early Somatic Homolog Pairing in Drosophila melanogaster

Homolog pairing is indispensable for the proper segregation of chromosomes in meiosis but the mechanism by which homologs uniquely pair with each other is poorly understood. In Drosophila, somatic chromosomes also undergo full homolog pairing by an unknown mechanism. It has been recently demonstrated that both insulator function and somatic long-distance interactions between Polycomb response elements (PREs) are stabilized by the RNAi machinery in Drosophila. This suggests the possibility that long-distance pairing interactions between homologs, either during meiosis or in the soma, may be stabilized by a similar mechanism. To test this hypothesis, we have characterized meiotic and early somatic chromosome pairing of homologous chromosomes in flies that are mutant for various components of the RNAi machinery. Despite the identification of a novel role for the piRNA machinery in meiotic progression and synaptonemal complex (SC) assembly, we have found that the components of the RNAi machinery that mediate long-distance chromosomal interactions are dispensable for homologous chromosome pairing. Thus, there appears to be at least two mechanisms that bring homologous sequences together within the nucleus: those that act between dispersed homologous sequences and those that act to align and pair homologous chromosomes

Neurosarcoidosis Masquerading as Cavernous Sinus Meningioma

Neurosacroidosis can mimic intracranial tumors resulting in a diagnostic and therapeutic challenge 1-4. We present a case of right cavernous sinus and superior orbital fissure sarcoidosis masquerading as meningioma on MRI and associated with bilateral optic neuropathy that caused serious vision loss

Predictive Factors of Research Productivity among Ophthalmology Residents: A Benchmark Analysis

Introduction Positive and negative associations between prior publications and future research productivity is described in other fields, but no such analysis exists for ophthalmology. We conducted a study to determine characteristics of residents exhibiting research productivity during residency. Methods Using San Francisco Match and Program Web sites, a roster of ophthalmology residents in 2019 to 2020 was compiled, and publication data was collected via PubMed and Google Scholar on a random sample of 100 third-year residents. Results The median number of publications generated by ophthalmology residents before residency is 2 (range 0–13). Thirty-seven, 23, and 40 residents had zero, one, and two or more papers published during residency, respectively, with a median of 1 (range 0–14). On univariate analysis, compared with residents who published zero or one paper, those who published ≥ 2 were more likely to have more preresidency publications (odds ratio [OR] 1.30; p = 0.005), attend a top-25 ranked residency program by multiple metrics including Doximity reputation (OR 4.92; p < 0.001), and have attended a top-25 ranked medical school program by U.S. News and World Report (OR 3.24; p = 0.03). However, on adjusted analyses, the only factor that remained significant for predicting publications in residency was whether the residency program attended was top 25 ranked (OR 3.54; p = 0.009). Discussion/Conclusion With the advent of the United States Medical Licensing Examination Step 1 pass/fail system, greater emphasis will be placed on other metrics, including research. This is the first benchmark analysis examining factors predictive of publication productivity in ophthalmology residents. Our study suggests that the residency program attended, not the medical school attended or prior publication history, plays an influential role in the number of publications produced during residency, highlighting the importance of factors to support research on the institutional level, such as mentorship and funding, rather than historical factors in research productivity by the resident