Optimisation of radiotherapy for carcinoma of the parotid gland: a comparison of conventional, three-dimensional conformal, and intensity-modulated techniques

Optimisation of radiotherapy for carcinoma of the parotid gland: a comparison of conventional, three-dimensional conformal, and intensity-modulated techniques. AB Background and purpose: To compare external beam radiotherapy techniques for parotid gland tumours using conventional radiotherapy (RT), three-dimensional conformal radiotherapy (3DCRT), and intensity-modulated radiotherapy (IMRT). To optimise the IMRT techniques, and to produce an IMRT class solution. Materials and methods: The planning target volume (PTV), contra-lateral parotid gland, oral cavity, brain-stern, brain and cochlea were outlined on CT planning scans of six patients with parotid gland tumours. Optimised conventional RT and 3DCRT plans were created and compared with inverse-planned IMRT dose distributions using dose-volume histograms. The aim was to reduce the radiation dose to organs at risk and improve the PTV dose distribution. A beam-direction optimisation algorithm was used to improve the dose distribution of the IMRT plans, and a class solution for parotid gland IMRT was investigated. Results: 3DCRT plans produced an equivalent PTV irradiation and reduced the dose to the cochlea, oral cavity, brain, and other normal tissues compared with conventional RT. IMRT further reduced the radiation dose to the cochlea and oral cavity compared with 3DCRT. For nine- and seven-field IMRT techniques, there was an increase in low-dose radiation to non- target tissue and the contra-lateral parotid gland. IMRT plans produced using three to five optimised intensity-modulated beam directions maintained the advantages of the more complex IMRT plans, and reduced the contra-lateral parotid gland dose to acceptable levels. Three- and four-field non-coplanar beam arrangements increased the volume of brain irradiated, and increased PTV dose inhomogeneity. A four-field class solution consisting of paired ipsilateral coplanar anterior and posterior oblique beams (15, 45, 145 and 170 degrees from the anterior plane) was developed which maintained the benefits without the complexity of individual patient optimisation. Conclusions: For patients with parotid gland tumours, reduction in the radiation dose to critical normal tissues was demonstrated with 3DCRT compared with conventional RT. IMRT produced a further reduction in the dose to the cochlea and oral cavity. With nine and seven fields, the dose to the contra-lateral parotid gland was increased, but this was avoided by optimisation of the beam directions. The benefits of IMRT were maintained with three or four fields when the beam angles were optimised, but were also achieved using a four- field class solution. Clinical trials are required to confirm the clinical benefits of these improved dose distributions

Algoritmo evolucionário para otimização do plano de tratamento em radioterapia conformal 3D

O planejamento do tratamento por radioterapia tem por objetivo atingir um volume alvo com altas doses de radiação tomando cuidado para não expor órgãos sadios a doses elevadas. É, portanto, muito importante que se encontre um balanço ideal entre esses objetivos conflitantes. O presente trabalho relata um modelo de programação matemática multiobjetivo e introduz um Algoritmo Transgenético para o problema de seleção do direcionamento dos feixes de radiação no planejamento em radioterapia conformal 3D. A seleção das direções dos feixes é feita através de uma técnica denominada de isocentros variáveis. Com a finalidade de testar o potencial do algoritmo desenvolvido, realiza-se um experimento comparativo com um Algoritmo Genético Multiobjetivo. O experimento computacional obtém dados quantitativos e qualitativos que são analisados no trabalho.<br>The radiotherapy treatment planning aims to achieve a target volume with high doses of radiation taking care not to expose healthy organs to high doses. It is therefore very important to find an optimal balance between these conflicting goals. This paper reports a mathematical model of multiobjective programming and presents a Transgenetic Algorithm for the problem of selecting the direction of radiation beams in 3D conformal radiotherapy planning. The selection of beams directions is done with a technique called variable isocenters. In order to test the potential of the developed algorithm, a comparative experiment with a multiobjective genetic algorithm was done. The computational experiment obtains quantitative and qualitative data that are analyzed in this paper