Understanding the Dynamics of Gene Regulatory Systems : Characterisation and Clinical Relevance of cis-Regulatory Polymorphisms

Peer reviewedPublisher PD

Infections of the nasal accessory sinuses and their relation to systemic disease

The subject of Nasal Accessory Sinus infection is a very important one, which has been but little understood until some thirty years ago, when ihinologists in America and on the Continent realised the importance of the many complicated cavities and cells in the anterior part of the skull and devoted a vast amount of time and study on the anatomy, histology, neurology and pathology of these spaces.In this paper I wish to discuss the whole subject of Nasal Accessory Sinus infection, and particularly as a factor in the Causation and maintenance of disease when unrecognised

Primary Educators’ Knowledge of Grammatical Concepts as Mandated in the Australian Curriculum (English): Comparison of Pre and In-Service Teachers

This study aims to improve grammar pedagogy in pre-service teaching institutions. While acknowledging grammar and grammar teaching are contentious issues, the National Curriculum, subsequent state curriculums and national testing, have refocused attention on whether teachers have the requisite subject knowledge to teach grammar to students effectively. Therefore, this mixed methods study contrasts pre-service and in-service teacher beliefs and experiences on grammar and grammar teaching, and knowledge of terminology and concepts, to inform pre-service pedagogical practice

Bridging the gap between Journalism 273 and graduation, and beyond

While Journalism 273: Creative Visual Thinking is a requirement for all undergraduate students majoring in Integrated Marketing Communications and some students majoring in Journalism, there are students who end up graduating from the University of Mississippi with a desire for more knowledge of graphic design. Feedback from current students in the School of Journalism and New Media at the University of Mississippi as well as alumni of the program was gathered in two surveys to understand better how Journalism 273 benefits them and pinpoints opportunities for improvement. One hundred nineteen students who took Journalism 273 and were enrolled in the School of Journalism and New Media for the spring 2022 semester were surveyed. An additional 119 alumni of the School of Journalism and New Media who took Journalism 273 and who graduated within the last five years were surveyed. The research asked the following questions: What projects in the class are the most favored? Based on experiences within Journalism 273, will current students take more classes related to graphic design? Did alumni take other classes besides this specific course? and after graduation, what applications are alumni using? Findings indicate that learning how to use Adobe software and mastering the applications are the most important to current and former students. Alumni indicated a need for the class to offer more about marketing and branding design as well as designing for social media

Cognitive deficits associated with long-term, low-level exposure to organophosphate pesticides: a small group study

Organophosphate (OPs) pesticides were derived from World War II nerve gas agents and are being increasingly used around the world for a variety of agricultural, industrial and domestic purposes. Concerns have been expressed about the effects of these chemicals on human health. Chronic ill health may follow recovery from acute organophosphate poisoning, but the possibility that repeated low level exposure may cause ill health is controversial as previous research has yielded inconsistent results. As an occupational group, farmers are considered to be at risk of low level exposure only.METHOD: The present study compared neuropsychological performance of 25 agricultural workers, exposed to organophosphate pesticides in the course of their work with 22 nonexposed healthy volunteers (controls) who were matched to the exposed group for age, gender, years spent in education and level of intelligence. All ofthe agricultural workers were involved in litigation.OBJECTIVE: To establish whether agricultural workers with a history of prolonged exposure to OPs show evidence of cognitive impairment and to determine whether the pattern of cognitive deficit relates to exposure history.FINDINGS: A range of cognitive and emotional problems were identified in agricultural workers. Although general intellectual ability was relatively well preserved in the exposed cohort, they obtained lower scores on tests of auditory verbal memory span, verbal learning, verbal fluency, mental flexibility, reading, visuo-spatial skill and information processing speed, than non-exposed controls. In addition, over 70% of the exposed cohort complained of clinically significant levels of anxiety and depression. They also reported a range of physical symptoms, the most prominent being fatigue, aching muscles and joints, headaches, sleep disturbance and irritability. Exposure history varied enormously amongst individuals who seemed to have similar jobs and many appeared to have a history of undiagnosed acute poisoning. This highlights the importance of taking an adequate exposure history.CONCLUSIONS: The question of whether low level exposure to OPs causes ill health will never be resolved without agreed definitions of acute versus low level exposure, adequate assessment of exposure history and consideration of individual vulnerability factors or synergistic effects of chemical combinations that may mediate the dose-response relationship

Studies on the biology of pathogenic fungi

1. An introduction to the subject of medical mycology is given with a brief indication of its scope and the organisms concerned. The nature of the Experimental Mycoses Unit is described and the objects of the present work defined.2. The first part of the work is a survey of the fungi occur -1 :ring in a variety of human sources, with especial reference to the yeasts. 1,004 samples were examined from urine, sputum, throat, high vaginal, wound, stool and other sources. 289 fungi (28.8%) were obtained; 248 (86%) of the isolates were yeasts.3. Candida albicans was the most common species and was isolated on 141 occasions (56% of the total number of yeasts). Other species were Torulopsis glabrata (31); Rhodotorula mucilaginosa (16); Candida tropicalis (12); Candida parapsilosis (7); Saccharomyces cerevisiae (4); Candida zeylanoides (4); Cryptococcus albidus (4); Saccharomyces fragilis (3); Candida krusei (3); Hansenula anomola (2); Pichia membranaefaciens (2); Saccharomyces carlsbergensis (1); Trichosporon cutaneum (1); Candida robusta (1)i Candida guilliermondii (1); Torulopsis famata (1); Torulopsis candida (1); Cryptococcus laurentii (1); Cryptococcus diffluens (1).4. Torulopsis glabrata is shown to be a significant member of the flora of the sources examined.5. A description of 11 isolates which were atypical is given with a discussion on their taxonomic affinities.6. Rhodotorula mucilaginosa was obtained from decaying vegetation; Candida guilliermondii was isolated from soil.7. A description is given of a strain of Candida tropicalis which was responsible for a fatal septicaemia.8. An evaluation of the methods used in the survey is provided.9. Tissue culture techniques were used to demonstrate phagocytosis of Candida albicans and Candida tropicalis.10. In vivo experiments showed that Candida albicans rapidly forms pseudomycelium. After 12 hours verticillate branching occurs. An association between branching and the presence of polymorpho- :nuclear leukocytes is indicated. Candida tropicalis also forms pseudómyycelium in vivo, but a check is evident after 4 hours. Pseudomycelial strands are branched and production of blastospores is not entirely suppressed.11. Blastospores of Torulopsis glabrata were predominantly intracellular within host phagocytes after 12 hours.12. Abortive pseudomycelium is demonstrated in Saccharomyces fragilis

Theology of the passion of Christ in the second century fathers

The term "second century Fathers" requires to be defined. On the one hand it is taken in this work to be more restrictive than the broader category, "early Christian Fathers who could be said to extend at least from Clement of Rom to Athanasius, i.e. from the first to the fourth century A.D. On the other hand the term which we have used is more comprehensive than the category, "Apostolic Fathers," for it allows us to discuss the beginnings of Christian Apology in the Epistle to Diognetus and Justin Martyr, an example of an Early Christian Homily in Melito of Sardis, sad the dominant figure in the polemical literature of this period, Irenaeus