On the acquisition of either and too

This paper presents an experimental investigation of how English-learning children acquire the additive discourse particles either and too. In the target grammar these items exhibit near-complementary distribution conditioned on the polarity of their host sentence. The path leading to that grammar appears to be rather intricate. We present comprehension data showing that for an extended period of time (3–5 ya) learners find both items acceptable in both polarity environments, exhibiting only a weak adult-like tendency of preferring either in negative and too in positive sentences. At 6 ya, their grammar appears categorical wrt. either in that they no longer tolerate it in positive sentences while still exhibiting only a weak dispreference for too in negative environments. These findings are even more striking in the context of production data. We find that child-directed speech is essentially categorical, providing unambiguous evidence for the adult grammar. Moreover, we find essentially categorical, adult-like use of either and too in child production from the earliest stage of development. These observations raise a number of challenges for theories of either and too and for approaches to learning focus particles more generally. Perhaps most strikingly, the protracted insensitivity of the learner's grammar to accumulation of unambiguous evidence constitutes a novel argument from the abundance of evidence for encapsulated learning

Data-driven analysis of immune infiltrate in a large cohort of breast cancer and its association with disease progression, ER activity, and genomic complexity.

The tumor microenvironment is now widely recognized for its role in tumor progression, treatment response, and clinical outcome. The intratumoral immunological landscape, in particular, has been shown to exert both pro-tumorigenic and anti-tumorigenic effects. Identifying immunologically active or silent tumors may be an important indication for administration of therapy, and detecting early infiltration patterns may uncover factors that contribute to early risk. Thus far, direct detailed studies of the cell composition of tumor infiltration have been limited; with some studies giving approximate quantifications using immunohistochemistry and other small studies obtaining detailed measurements by isolating cells from excised tumors and sorting them using flow cytometry. Herein we utilize a machine learning based approach to identify lymphocyte markers with which we can quantify the presence of B cells, cytotoxic T-lymphocytes, T-helper 1, and T-helper 2 cells in any gene expression data set and apply it to studies of breast tissue. By leveraging over 2,100 samples from existing large scale studies, we are able to find an inherent cell heterogeneity in clinically characterized immune infiltrates, a strong link between estrogen receptor activity and infiltration in normal and tumor tissues, changes with genomic complexity, and identify characteristic differences in lymphocyte expression among molecular groupings. With our extendable methodology for capturing cell type specific signal we systematically studied immune infiltration in breast cancer, finding an inverse correlation between beneficial lymphocyte infiltration and estrogen receptor activity in normal breast tissue and reduced infiltration in estrogen receptor negative tumors with high genomic complexity

Vaccine Preventability of Meningococcal Clone, Greater Aachen Region, Germany

An emerging serogroup B clone can be prevented by vaccines

Scalar Inferences in the Acquisition of Even

Scalar inferences are ubiquitous in human reasoning. Correspondingly, language has many means of expressing and encoding them. One of these means is the focus particle even, which utilizes scalar inferences to signal the pragmatic status of asserted content as noteworthy. The vehicles that even employs to signal noteworthiness are scalar likelihood inferences. A peculiarity of these inferences is that they are presuppositional in nature (not-at-issue) and yet, they are responsive to the polarity of the sentence expressing the proposition whose likelihood is signaled. This property raises intricate questions about what learners might expect scalar operators of this sort to look like (initial hypothesis space) as well as what type of evidence and learning strategies they have access to as they figure out the specific properties of even in adult English. This paper presents a detailed study of this development, combining data from a series of comprehension experiments and corpus studies. We find that children are sensitive to the basic scalar nature of even much earlier than previous literature has claimed. We additionally find, however, that children sometimes exhibit non-adult-like responses to even sentences, which we argue provide insight into their developing grammar. On this view, the child grammar offers a larger option space for even than the adult grammar. Becoming adult-like, in turn, involves eliminating some of these options, namely those that are underutilized in production due to their limited conversational value

The Influence of Insecure Attachment to Parents on Adolescents’ Suicidality

Insecure attachment has been identified as a risk factor for adolescent psychopathology and, consequently, for suicidal behavior. We aimed to highlight the relationship between the attachment styles of adolescents and their suicidal behavior and to investigate the role of each parent in the suicidality pathway of adolescents. The sample consisted of 217 adolescent inpatients who were at the highest risk for suicidal behavior and who were hospitalized in the Unit for Intensive Child and Adolescent Psychiatry. Self-report questionnaires assessing their attachment to their parents, their acquired capability for attempting suicide, their suicidality, and a number of traumatic life events were administered. The results showed a higher level of attachment avoidance rather than attachment anxiety among the most at-risk adolescents. An acquired capability for suicide (ACS) mediated the positive correlation between adolescents’ attachment avoidance in relation to the mother or father and their suicidality. The suppressive mediating effect of an ACS on the association between attachment anxiety in relation to the father and suicidality was detected. The odds ratio for attempted suicide was more than two times higher for adolescents who were insecurely attached to their father compared to adolescents who were insecurely attached to their mother. Our results confirmed the importance of attachment, especially paternal attachment, in developing suicidality during adolescence. Preventive and clinical interventions should target these important domains with the aim of decreasing suicidality among adolescents