1 research outputs found
Biology of glucose metabolization in cancer cells
Cancer is a disease at the cellular level involving heritable disorders in cellular control mechanism.
Cancer cells also need to adapt their metabolism to survive and multiply under the metabolically
compromised conditions provided by the tumor microenvironment. Tumor cells alter their metabolism
to maintain unregulated cellular proliferation and survival, but this transformation leaves them reliant
on constant supply of nutrients and energy. They alter their metabolism to support their rapid prolif-
eration and expansion across the body. After the discovery of based on the altered cancer cell metabolism
in 1930, loads of studies have shed light on several aspects of cancer metabolism with a common goal to
fi
nd new ways for effectively eliminating tumor cells by targeting their energy metabolism. Research has
directed most of its resources to elucidate the causes, prevention and possible cure for cancer, yet the
process has been elusive claiming human lives more than ever. This disease is a manifestation of etio-
logical and pathological disturbances of mechanisms that control cell division, differentiation and
metabolism. 50% of all human tumors carry genetic alterations that lead to the inactivation of some
tumor suppressor proteins. Cancer cells are shown to experience characteristic changes in their meta-
bolic programs, including increased uptake of glucose, enhanced rates of glutaminolysis and fatty acids
synthesis, suggesting that metabolic shifts supports tumor cells growth and survival. In this review, we
summarized the major concepts of glucose metabolization and explore the molecular basis of aerobic
glycolysis of cancer cell