The spatial epidemiology of the Duffy blood group and G6PD deficiency

Over a third of the world’s population lives at risk of potentially severe Plasmodium vivax malaria. Unique aspects of this parasite’s biology and interactions with its human host make it harder to control and eliminate than the better studied Plasmodium falciparum parasite. Spatial mapping of two human genetic polymorphisms were developed to support evidence-based targeting of control interventions and therapies. First, to enumerate and map the population at risk of P. vivax infection (PvPAR), the prevalence of this parasite’s human blood cell receptor – the Duffy antigen – was mapped globally. Duffy negative individuals are resistant to infection, and this map provided the means to objectively model the low endemicity of P. vivax across Africa. The Duffy maps helped resolve that only 3% of the global PvPAR was from Africa. The second major research focus was to map the spatial distribution of glucose-6-phosphate dehydrogenase enzyme deficiency (G6PDd), the genetic condition which predisposes individuals to potentially life-threatening haemolysis from primaquine therapy. Despite this drug’s vital role in being the only treatment of relapsing P. vivax parasites, risks of G6PDd-associated haemolysis result in significant under-use of primaquine. G6PDd was found to be widespread, with an estimated frequency of 8.0% (50% CI: 7.4-8.8%) across malarious regions. Third, it was important to represent more detailed descriptions of the genetic diversity underpinning this enzyme disorder, which ranges in phenotype from expressing mild to life-threatening primaquine-induced haemolysis. These variants’ spatial distributions were mapped globally and showed strikingly conspicuous distributions, with widespread A- dominance across Africa, predominance of the Mediterranean variant from the Middle East across to India, and east of India diversifying into a different and diverse array of variants, showing heterogeneity both at regional and community levels. Fourth, the G6PDd prevalence and severity maps were synthesised into a framework assessing the spatial variability of overall risk from G6PDd to primaquine therapy. This found that risks from G6PDd were too widespread and potentially severe to sanction primaquine treatment without prior G6PDd screening, particularly across Asia where the majority of the population are Duffy positive and G6PDd was common and severe. Finally, the conclusions from these studies were discussed and recommendations made for essential further research needed to support current efforts into P. vivax control

A continuum theory of phase separation kinetics for active Brownian particles

Active Brownian particles (ABPs), when subject to purely repulsive interactions, are known to undergo activity-induced phase separation broadly resembling an equilibrium (attraction-induced) gas-liquid coexistence. Here we present an accurate continuum theory for the dynamics of phase-separating ABPs, derived by direct coarse-graining, capturing leading-order density gradient terms alongside an effective bulk free energy. Such gradient terms do not obey detailed balance; yet we find coarsening dynamics closely resembling that of equilibrium phase separation. Our continuum theory is numerically compared to large-scale direct simulations of ABPs and accurately accounts for domain growth kinetics, domain topologies and coexistence densities

Ecoconsciousness in the Works of Select American Writers

American authors have shown a special interest in ecology right from the times of Transcendentalism. The transcendentalists especially are of the opinion that Divinity is revealed through Nature and when people communicate with Nature it’s a means of connecting with God. This idea was advocated by Ralph Waldo Emerson, Nathaniel Hawthorne, Robert Frost, Kate Chopin and Sarah Orne Jewett. These authors are sensitive to their environment and demonstrate ecoconsciousness through their works, which paved way for a distinct class of writing

Valuing Private and Public Greenspace Using Remotely Sensed Vegetation Indices

In a typical metropolitan area, greenspace varies substantially in its quality and extent. Remotely sensed vegetation index data is used to characterize the heterogeneity in private and public greenspace (riparian corridors) in metropolitan Tucson, Arizona. This data set enables the researcher to test if: (1) greenness is a significant determinant of house price variation in this desert city; and (2) whether there is an interaction between public and private greenspace. Private greenspace amenities can be endogenously improved by homeowners as a complement or substitute for the greenspace that is publicly provided, whereas public greenspace might be exogenous or endogenous depending on households ability to pressure the local government to protect or restore public greenspace. The results of a Hausman test indicate that endogeneity is a problem in the dataset and therefore an instrumental variable two stage least squares estimation is used. The results of this analysis indicate that homebuyers in the study area have preferences for both greener lots and greener riparian corridors and that private and public greenspace appear to be substitutes. Results are robust across multiple identification strategies designed to address potential endogeneity. The study results could have fundamental implications for the efficient use of limited water supplies in this semi-arid metropolitan area.Resource /Energy Economics and Policy,

BIRTH ORDER AND AGE AS FACTORS IN EMOTIONALLY-TRIGGERED ASTHMA1 1Received August, 1970.

It has been observed by Gibson (1966) that the incidence of bronchial asthma is 7% to 9% of the total population of school children in Tasmania

How Do Homebuyers Value Different Types of Green Space?

It is important to understand tradeoffs in preferences for natural and constructed green space in semi-arid urban areas because these lands compete for scarce water resources. We perform a hedonic study using high resolution, remotely-sensed vegetation indices and house sales records. We find that homebuyers in the study area prefer greener lots, greener neighborhoods, and greener nearby riparian corridors, and they pay premiums for proximity to green space amenities. The findings have fundamental implications for the efficient allocation of limited water supplies between different types of green space and for native vegetation conservation in semi-arid metropolitan areas.hedonic model, locally weighted regression, spatial, open space, golf course, park, riparian, Consumer/Household Economics, Land Economics/Use,

Do Homebuyers Care about the 'Quality' of Natural Habitats?

We study if homebuyers in Tucson, Arizona care about the condition of natural habitats and if they have preferences between natural and manmade habitats. Using field work data we examine whether homebuyers willingness to pay is influenced by the biological condition of the neighboring riparian habitat and how homebuyers value alternative manmade green areas, specifically golf courses. We also explore the relationship between the field data and remote sensing vegetation indices. The results of a hedonic analysis of houses that sold within 0.2 miles of 51 stratified-random selected riparian survey sites in Tucson, Arizona reveals that homebuyers significantly value habitat quality and negatively value manmade park-like features. Homebuyers are willing to pay twenty percent more to live near a riparian corridor that is densely vegetated and contains more shrub and tree species, particularly species that are dependent on perennial water flow. These environmental premiums are significant, outweighing structural factors such as an additional garage or swimming pool. Likewise, proximity to a riparian habitat with low biological quality or to a golf course lowers property values.Land Economics/Use,