EFECTOS DE LA INVERSIÓN PÚBLICA SOBRE LA INVERSIÓN PRIVADA EN MÉXICO: 1940-2015

Debido a la falta de unanimidad entre los efectos que pueda tener la inversión pública sobre la privada surge el interés de analizar qué relación hay entre ambas variables. Además, las investigaciones que se encuentran no abarcan un periodo de análisis tan extenso y de alguna manera la historia económica de México es atractiva para analizarla y conocer a detalle el comportamiento de la inversión privada y cómo las fluctuaciones de otros indicadores macroeconómicos repercuten en ésta. Por estos motivos, el objetivo de este trabajo es analizar los efectos de la inversión pública sobre la dinámica de la inversión privada en México durante el periodo de 1940- 2015 y de esta forma contribuir al debate de si la relación es de atracción, desplazamiento o si son independientes una de la otra. Además, se incluyen otras variables que tengan posibles efectos sobre su comportamiento. Para cumplir con el objetivo mencionado el documento se divide en tres capítulos: En el primero se exponen las principales teorías que describen la relación inversión públicainversión privada, además de otros determinantes de la inversión privada. En el segundo capítulo se describe como ha sido el comportamiento de la inversión privada 9 desde una perspectiva histórica en torno a las medidas de política económica, haciendo énfasis en la política fiscal (inversión pública). El tercer capítulo describe la metodología econométrica empleada para estimar la relación existente entre la inversión pública y su contraparte en el corto y largo plazo, así como su relación con otras variables; y se discuten los resultados. Al final se establecen las principales conclusiones

Diabetes Related Distress and Co-Occurrence with Depressive Symptoms in Urban Low-Income African American and Hispanic/Latinx Adults with Type 2 Diabetes

Introduction. Burden of diabetes in the U.S. is greater in racial-ethnic minority populations than non-Hispanic Whites. Depression and diabetes-related distress (DRD) are recognized as relatively common and important psychosocial areas to address in people living with diabetes. Limited research in the U.S. has focused on DRD in racial-ethnic minority populations. The purpose of this study is to describe patterns of DRD and co-occurrence with depressive symptoms in urban low-income African American and Hispanic/Latinx adults with type 2 Diabetes Mellitus (T2DM). Method. We examined the baseline data collected for a randomized clinical trial (RCT) studying the impact of a culturally tailored diabetes self-care intervention. Individuals with T2DM who self-identified as African American or Hispanic/Latinx were recruited from Federally Qualified Health Centers (FQHCs). Measurement scales included the Patient Health Questionnaire (PHQ-9) and Diabetes Distress Scale (DDS). Participants were categorized into four groups based on the PHQ-9 and DDS: high distress (without probable clinical depression), probable clinical depression (without high distress), both high distress and probable depression, or neither high distress nor probable depression. Baseline variables were summarized by sex, age and racial-ethnic group. Analyses included independent sample t-tests, Chi-square tests, and one-way Analysis of Variance (ANOVA). Results. The study sample included 247 participants with 118 (47.8%) Hispanic/Latinx and 129 (52.2%) African American adults with T2DM. The mean age was 52.9 years (SD=12.2) and 68.0% were female. Based on PHQ-9 scores, 51.4% had none to minimal, 23.5% mild, and 25.1% moderate-severe depressive symptomatology. Based on the DDS, 37.7% had little to no DRD, 27.1% moderate, and 35.2% high DRD. There was not a statistically significant relationship between sex and depression or DRD levels. There was not a statistically significant difference between age and depression; however, there was a statistically significant difference between age and DRD (p=.002). When examining the co-occurrence of DRD and depression, over half of the participants did not experience high distress nor probable clinical depression (57.5%), 17.8% experienced both high distress and depression, 17.4% experienced high distress without depression, and 7.3% experienced depression without distress. There was no statistically significant relationship found between sex and co-occurrence groups; however, there was a statistically significant difference for age (p=.003). Discussion. A substantial proportion of individuals from both racial-ethnic groups experienced high DRD and/or probable clinical depression with some differences for age. Patterns found for specific DRD areas and co-occurrence of DRD and depressive symptoms can help clinicians better understand and address these challenges

Happy Hearts: Associations of Maternal Depressive Symptomatology on Child Profiles of C-Reactive Protein

Elevated concentrations of inflammatory markers in the bloodstream, such as C-reactive protein (CRP), can predict development of obesity and cardiometabolic dysfunction. Elevated CRP levels are found as early as infancy among children born to mothers with maternal depression. Little is known, however, of the intergenerational influence of maternal depression on offspring’s CRP profiles and the associated obesity risks during childhood, particularly in high-risk populations with limited resources. Cross-sectional data was collected from low-income Mexican mother-child dyads (n=97) living in central Mexico enrolled in the Family-based Intergenerational Evaluation of Salivary Telomeres and Acculturation (FIESTA) study. Mothers completed the Patient Healthcare Questionnaire (PHQ-9) to screen for depression. Body composition through bioelectrical impedance and dried blood spots were collected across all dyads. An enzyme-linked immunosorbent assay (ELISA) kit will be used to measure CRP from dried blood spots. Mothers ranged in age from 19 to 55 (M=31.29±8.42). Half the mothers were overweight (50.5%), and 23.7% met criteria for obesity, and 15.5% of mothers had elevated depressive symptoms (PHQ-9 ≥9 ). Children were between the ages of 3 to 6 years old (M=4.58±0.57). About 48.2% of children were male, 13.4% of children were overweight and 20.7% were considered obese. Results are forthcoming for CRP profiles, but we anticipate a positive association with body weight and moderation of this relationship (if any) by maternal depression status. This study has the potential to introduce preliminary evidence of the intergenerational interaction between maternal depressive symptoms and childhood CRP profiles and subsequent effect on child weight status.Office of Undergraduate ResearchOpe

Psychological Well-being’s Link With Cardiovascular Health in Older Adults

Introduction Favorable cardiovascular health (FCH) is associated with healthy longevity and reduced cardiovascular mortality risk. However, limited work has investigated the distribution of FCH in older age or considered the antecedents of FCH. Based on prior work linking psychological well-being with cardiovascular endpoints, higher psychological well-being was hypothesized to be associated with increased likelihood of maintaining FCH over time. Methods Data were from the English Longitudinal Study of Ageing. The first study wave (2002–2003) included men and women aged ≥50 years. The analytic sample (N=4,925) was restricted to individuals without baseline cardiovascular disease and with clinical data from three follow-ups through 2013. Psychological well-being was assessed with 17 items from the Control, Autonomy, Satisfaction, and Pleasure scale. FCH was defined as being a non-smoker, diabetes-free, and having healthy levels of blood pressure, cholesterol, and BMI (FCH scores ranged from 0–5). Statistical analyses conducted in 2016–2017 used linear mixed models to examine associations between psychological well-being and FCH scores over time. Secondary analyses examined cardiovascular-related mortality. Results Only 1% of participants had achieved complete FCH at study baseline. Adjusting for sociodemographic factors and depression, greater psychological well-being was associated with higher FCH scores across time (β=0.05, 95% CI=0.02, 0.08), but not rate of change in FCH. Psychological well-being was also associated with a 29% reduced risk of cardiovascular-related mortality in multivariable-adjusted models. Conclusions Findings suggest that psychological well-being is associated with having FCH at older ages, and add to knowledge of assets that may increase likelihood of healthy aging

Positive Emotions and Favorable Cardiovascular Health: A 20-Year Longitudinal Study

No studies have examined whether positive emotions lead to favorable cardiovascular health (CVH) early in the lifespan, before cardiovascular disease is diagnosed. Moreover, the direction of the association has not been thoroughly investigated. Among younger adults, we investigated whether baseline positive emotions were associated with better CVH over 20 years. We also considered whether baseline CVH was associated with subsequent positive emotions during the same period. Participants included 4196 Black and White men and women from the Coronary Artery Risk Development in Young Adults Study. Positive emotions and cardiovascular-related parameters were each assessed in 1990 (this study\u27s baseline), with repeated assessment through 2010. CVH was defined by blood pressure, lipids, body mass index, diabetes, and smoking status. Primary analyses used linear mixed effects models adjusting for potential confounders; secondary analyses stratified by race and sex. Controlling for sociodemographic factors, greater baseline positive emotions were associated with better CVH across time (β = 0.03, 95% confidence interval = 0.007–0.06). However, positive emotions were unrelated to rate of change in CVH across time. Baseline CVH was also associated with greater average positive emotions across time (β = 0.09, 95% confidence interval = 0.02–0.15), but not rate of change. Positive emotions\u27 association with CVH was stronger for women than men, but race did not modify associations. Positive emotions in early to middle adulthood were associated with better CVH across several decades. Baseline CVH was also associated with greater positive emotions during follow-up. Future research may be able to disentangle these relationships by assessing positive emotions and CVH earlier in life

Optimism and Cardiovascular Health: Longitudinal Findings from the CARDIA Study

Objective: Favorable cardiovascular health is associated with greater longevity free of cardiovascular disease. Although the prevalence of cardiovascular health decreases with age, less is known about protective factors that promote and preserve it over time. We investigated whether optimism was associated with better cardiovascular health over a 10-year period. Methods: Participants included 3,188 Black and White men and women from the Coronary Artery Risk Development in Young Adults Study. Self-reported optimism was assessed in 2000 (this study’s baseline) with the revised Life Orientation Test. Favorable cardiovascular health was defined by healthy status on five components of cardiovascular functioning that were repeatedly assessed through 2010 either clinically or via self-report (blood pressure, lipids, body mass index, diabetes, and smoking status). Linear mixed effects models examined whether optimism predicted cardiovascular health over time, adjusting for covariates such as sociodemographic characteristics, health behaviors, health status, and depression diagnosis. Results: In models adjusting for sociodemographic characteristics, optimism was associated with better cardiovascular health across all time points (β=0.08, 95% confidence interval=0.04-0.11, p≤.001), but not with rate of change in cardiovascular health. Findings were similar when adjusting for additional covariates. Optimism did not interact significantly with race (p=0.85), but did with sex such that associations appeared stronger for women than men (p=0.03). Conclusions: Optimism may contribute to establishing future patterns of cardiovascular health in adulthood, but other factors may be more strongly related to how slowly or quickly cardiovascular health deteriorates over time

Genome-wide search identifies Ccnd2 as a direct transcriptional target of Elf5 in mouse mammary gland

<p>Abstract</p> <p>Background</p> <p>The ETS transcription factor Elf5 (also known as ESE-2) is highly expressed in the mammary gland and plays an important role in its development and differentiation. Indeed studies in mice have illustrated an essential role for Elf5 in directing alveologenesis during pregnancy. Although the molecular mechanisms that underlie the developmental block in Elf5 null mammary glands are beginning to be unraveled, this investigation has been hampered by limited information about the identity of Elf5-target genes. To address this shortcoming, in this study we have performed ChIP-cloning experiments to identify the specific genomic segments that are occupied by Elf5 in pregnant mouse mammary glands.</p> <p>Results</p> <p>Sequencing and genomic localization of <it>cis</it>-regulatory regions bound by Elf5 <it>in vivo </it>has identified several potential target genes covering broad functional categories. A subset of these target genes demonstrates higher expression levels in Elf5-null mammary glands suggesting a repressive functional role for this transcription factor. Here we focus on one putative target of Elf5, the <it>Ccnd2 </it>gene that appeared in our screen. We identify a novel Elf5-binding segment upstream of the <it>Ccnd2 </it>gene and demonstrate that Elf5 can transcriptionally repress Ccnd2 by directly binding to the proximal promoter region. Finally, using Elf5-null mammary epithelial cells and mammary glands, we show that loss of Elf5 <it>in vivo </it>leads to up regulation of Ccnd2 and an altered expression pattern in luminal cells.</p> <p>Conclusions</p> <p>Identification of Elf5-targets is an essential first step in elucidating the transcriptional landscape that is shaped by this important regulator. Our studies offer new toolbox in examining the biological role of Elf5 in mammary gland development and differentiation.</p

Optimism and Cardiovascular Health: Multi-Ethnic Study of Atherosclerosis (MESA)

Objectives We examined the cross-sectional association between optimism and cardiovascular health (CVH). Methods We used data collected from adults aged 52–84 who participated in the Multi-Ethnic Study of Atherosclerosis (MESA) (n=5,134) during the first follow-up visit (2002–2004). Multinomial logistic regression was used to examine associations of optimism with ideal and intermediate CVH (with reference being poor CVH), after adjusting for socio-demographic factors and psychological ill-being. Results Participants in the highest quartile of optimism were more likely to have intermediate [OR=1.51:95%CI=1.25,1.82] and ideal [OR=1.92:95%CI=1.30,2.85] CVH when compared to the least optimistic group. Individual CVH metrics of diet, physical activity, BMI, smoking, blood sugar and total cholesterol contributed to the overall association. Conclusions We offer evidence for a cross-sectional association between optimism and CVH

The Association of Optimism with Sleep Duration and Quality: Findings from the Coronary Artery Risk and Development in Young Adults (CARDIA) Study

Optimism is associated with better health outcomes with hypothesized effects due in part to optimism\u27s association with restorative health processes. Limited work has examined whether optimism is associated with better quality sleep, a major restorative process. We test the hypothesis that greater optimism is associated with more favorable sleep quality and duration. Main analyses included adults aged 32-51 who participated in the Coronary Artery Risk Development in Young Adults (CARDIA) study (n = 3,548) during the fifth (Year 15: 2000-2001) and sixth (Year 20: 2005-2006) follow-up visits. Optimism was assessed using the revised Life-Orientation Test. Self-report measures of sleep quality and duration were obtained twice 5 years apart. A subset of CARDIA participants (2003-2005) additionally provided actigraphic data and completed the Pittsburgh Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS). Multivariate regression analyses were used to examine associations of optimism and sleep indicators. In cross-sectional analyses of 3548 participants, each standard deviation (SD) higher optimism score resulted in 78% higher odds of self-reporting very good sleep quality. Prospectively, a 1-SD higher optimism score was related to higher odds of reporting persistently good sleep quality across 5-years relative to those with persistently poor sleep [OR = 1.31; 95%CI:1.10,1.56]. In participant with supplementary data, each SD higher optimism score was marginally associated with 22% greater odds of favorable sleep quality [OR = 1.22; 95%CI:1.00,1.49] as measured by the PSQI, with possible mediation by depressive symptoms. Optimism was unrelated to objective actigraphic sleep data. Findings support a positive cross-sectional and prospective association between optimism and self-reported sleep behavior