Triagem de hemoglobinopatias: resposta de uma comunidade brasileira a programas opcionais

The efficiency and the viability of three hemoglobin screening programs were investigated. They were offered on a voluntary basis to a Brazilian population and started with the analysis of blood donors, pregnant women and students. The hemoglobin screening was done through optional exams which included electrophoresis of hemoglobin and complementary hematological tests. A total of 13,670 people were tested over a period of 39 months and a total of 644 individuals with hereditary hemoglobin disorders were detected - 4.7% of the samples examined. The programs showed satisfactory indicators of viability and efficiency, expressed by the significative proportion of exams performed among the probands and their relatives.Foram testadas a viabilidade e a eficiência de três programas de triagem de hemoglobinopatias. Os programas foram oferecidos voluntariamente a uma população brasileira e iniciaram com o exame de doadores de sangue, gestantes e escolares dos ensinos fundamental e médio. A triagem das hemoglobinopatias foi realizada mediante exames opcionais, representados pela eletroforese de hemoglobinas e exames complementares. Um total de 13.670 pessoas foram investigadas em um período de 39 meses, diagnosticando-se 644 portadores de alterações hereditárias da hemoglobina - 4,7% da amostra examinada. Os programas mostraram indicadores satisfatórios de viabilidade e de eficiência, expressos pela proporção significativa de exames realizados entre os propósitos e os seus parentes.59159

A atividade da pseudocolinesterase em alcoolatras

Orientador : Bernardo BeiguelmanDissertação (mestrado) - Universidade Estadual de Campinas, Instituto de BiologiaResumo: A influência do alcoolismo crônico sobre a atividade da pseudocolinesterase foi estudada em uma amostra de 125 pacientes alcoólatras crônicos do sexo masculino, internados no Sanatório Antonio Luiz Sayão na cidade de Araras (SP). Os valores da atividade da pseudocolinesterase observados em um mesmo paciente na admissão e na alta hospitalar foram comparados por meio do teste t para dados emparelhados ficando demonstrado que o nível de pseudocolinesterase aumenta significativamente no maioria dos alcoólatras após um período de abstinência de um mês. A diferença entre a atividade da pseudocolinesterase na alta e na admissão hospitalar não se mostrou correlacionada à idade, à cor, à estatura, ao peso corporal, ao volume de álcooI ingerido diariamente, à duração do alcoolismo, nem ao aumento do fígadoAbstract: The influence of chronic alcoholism on pseudocholinesterase activity was studied in a sample of 125 male alcoholics. The activity of pseudocholinesterase at admission and hospital discharge was analysed by a t test for paired data. It was demonstrated that pseudocholinesterase rises significantly in the majority of chronic alcoholics after a month abstinency. The difference between pseudocholinesterase activity at admission and hospital discharge was not correlated to age, ethnical group, body height, daily alcohol volume consumption, duration of alcoholism nor liver enlargementMestradoMestre em Ciências Biológica

Viabilidade e eficiencia de um programa de hemoglobinopatias hereditaria em uma comunidade brasileira (Araras, SP) abordada a partir das gestantes

Orientador : Antonio Sergio RamalhoTese (doutorado) - Universidade Estadual de Campinas, Instituto de BiologiaDoutoradoGeneticaDoutor em Ciências Biológica

Increased fertility as an eventual mechanism maintaining high frequencies of hemoglobinopathies in Brazil

Abstract Increased fertility of heterozygous women is one of the suggested processes maintaining balanced polymorphism of the hemoglobinopathies in some countries. In the present work we studied the fertility of 68 b-thalassemia trait (heterozygous AT) and 53 sickle cell trait (heterozygous AS) women married with normal hemoglobin husbands. The average number of children per heterozygous AT and AS women (2.7647 and 3.0755, respectively) did not differ significantly from those observed among their control sisters with normal hemoglobin (2.3778 and 3, respectively). In addition, it was not observed a significant difference between the proportion of married women without children between the heterozygous women and their control sisters. The results herein presented hence does not support the hypothesis of increased fertility of heterozygous women as being a homeostatic mechanism able to maintain the polymorphism of either b-thalassemia and hemoglobin S in Brazil.O aumento da fertilidade das heterozigotas é um dos mecanismos sugeridos na manutenção do polimorfismo balanceado das hemoglobinopatias em alguns países. No presente trabalho, estudamos a fertilidade de 68 portadoras do traço talassêmico b (heterozigotas AT) e de 53 portadoras do traço falciforme (heterozigotas AS) casadas com indivíduos com hemoglobina normal. O número médio de filhos por heterozigotas AT e AS (2,7647 e 3,0755, respectivamente) não diferiu significativamente do observado entre suas irmãs com hemoglobina normal (2,3778 e 3, respectivamente). Além disso, também não foi observada diferença significativa, quanto à proporção de mulheres casadas sem filhos, entre as heterozigotas e as suas irmãs. Tais resultados não favorecem, portanto, a hipótese de que o aumento de fertilidade das heterozigotas seja um mecanismo de manutenção do polimorfismo da talassemia b e da hemoglobina S no Brasil.28929

Hemoglobin screening: response of a Brazilian community to optional programs

The efficiency and the viability of three hemoglobin screening programs were investigated. They were offered on a voluntary basis to a Brazilian population and started with the analysis of blood donors, pregnant women and students. The hemoglobin screening was done through optional exams which included electrophoresis of hemoglobin and complementary hematological tests. A total of 13,670 people were tested over a period of 39 months and a total of 644 individuals with hereditary hemoglobin disorders were detected - 4.7% of the samples examined. The programs showed satisfactory indicators of viability and efficiency, expressed by the significative proportion of exams performed among the probands and their relatives

Hemoglobin screening: response of a Brazilian community to optional programs Triagem de hemoglobinopatias: resposta de uma comunidade brasileira a programas opcionais

The efficiency and the viability of three hemoglobin screening programs were investigated. They were offered on a voluntary basis to a Brazilian population and started with the analysis of blood donors, pregnant women and students. The hemoglobin screening was done through optional exams which included electrophoresis of hemoglobin and complementary hematological tests. A total of 13,670 people were tested over a period of 39 months and a total of 644 individuals with hereditary hemoglobin disorders were detected - 4.7% of the samples examined. The programs showed satisfactory indicators of viability and efficiency, expressed by the significative proportion of exams performed among the probands and their relatives.Foram testadas a viabilidade e a eficiência de três programas de triagem de hemoglobinopatias. Os programas foram oferecidos voluntariamente a uma população brasileira e iniciaram com o exame de doadores de sangue, gestantes e escolares dos ensinos fundamental e médio. A triagem das hemoglobinopatias foi realizada mediante exames opcionais, representados pela eletroforese de hemoglobinas e exames complementares. Um total de 13.670 pessoas foram investigadas em um período de 39 meses, diagnosticando-se 644 portadores de alterações hereditárias da hemoglobina - 4,7% da amostra examinada. Os programas mostraram indicadores satisfatórios de viabilidade e de eficiência, expressos pela proporção significativa de exames realizados entre os propósitos e os seus parentes

Hemoglobin screening: response of a Brazilian community to optional programs

The efficiency and the viability of three hemoglobin screening programs were investigated. They were offered on a voluntary basis to a Brazilian population and started with the analysis of blood donors, pregnant women and students. The hemoglobin screening was done through optional exams which included electrophoresis of hemoglobin and complementary hematological tests. A total of 13,670 people were tested over a period of 39 months and a total of 644 individuals with hereditary hemoglobin disorders were detected - 4.7% of the samples examined. The programs showed satisfactory indicators of viability and efficiency, expressed by the significative proportion of exams performed among the probands and their relatives