2 research outputs found
Plasma prekallikrein levels are positively associated with circulating lipid levels and the metabolic syndrome in children.
Plasma prekallikrein (PK) has been shown to be associated with cardiovascular disease (CVD) and its risk factors, but these associations have not been investigated in children. The present study examined PK activity in relation to well-established cardiovascular risk factors in a cohort of children aged 9ā11 years (N = 97). We found a significant and positive association between PK and fasting levels of total cholesterol (p \u3c 0.01), non-high-density lipoprotein cholesterol (p \u3c 0.01), and triglycerides (p \u3c 0.001). In addition, there was a significant association between PK activity and the metabolic syndrome, a clustering of risk factors considered to have an impact on atherosclerosis and CVD mortality. Finally, we found that children with a family history of CVD had significantly elevated PK activity. These novel findings warrant further investigations into the relationship between circulating PK levels and CVD risk factors because PK may be involved in the progression of the disease state. Il est bien connu que la preĀ“kallicreĀ“ine (PK) est associeĀ“e a` la maladie cardiovasculaire (CVD) et a` ses facteurs de risque, mais ces associations nāont pas eĀ“teĀ“ veĀ“rifieĀ“es chez les enfants. Cette eĀ“tude se propose de veĀ“rifier lāassociation entre lāactiviteĀ“ de la PK et les facteurs de risque de CVD aupre`s dāune cohorte dāenfants aĖgeĀ“s de 9 a` 11 ans (N = 97). On observe une correĀ“lation positive significative entre la PK et les variables suivantes : la concentration totale de cholesteĀ“rol a` jeun (p \u3c 0,01), les concentrations des lipoproteĀ“ines non a` haute densiteĀ“ (p \u3c 0,01) et la concentration des triglyceĀ“rides (p \u3c 0,001). De plus, on observe une correĀ“lation significative entre lāactiviteĀ“ de la PK et le syndrome meĀ“tabolique constitue par un ensemble de facteurs ayant un effet sur lāatheĀ“roscleĀ“rose et la mortaliteĀ“ due a` la CVD. En dernier lieu, les enfants avec des anteĀ“ceĀ“dents familiaux de CVD preĀ“sentent une plus importante activiteĀ“ de la PK, et ce, de facĀøon significative. Ces premie`res observations sugge`rent dāautres eĀ“tudes sur la relation entre la concentration sanguine de PK et les facteurs de risque de CVD, car la PK pourrait eĖtre impliqueĀ“e dans la progression de la malad