Antidepressant activity of Trigonella foenum leaves in Wistar albino rats

Background: To evaluate antidepressant activity of ethanolic extract of Trigonella foenum in animal models.Methods: A total of 60 healthy male Wistar albino rats weighing 220-250 grams were used and they were divided into 10 groups of 6 rats in each. First five groups (1st -5th) were evaluated by Forced Swim Test (FST) and remaining by Tail Suspension Test (TST). 1st group (control) received normal saline 10 mg/kg, 2nd group (standard) Imipramine 10 mg/kg and 3rd, 4th and 5th groups (test) respectively received Trigonella foenum leaf ethanolic extract [TFEE] in different doses 100 mg, 200 mg, and 400 mg/kg per orally for 14 days. They were evaluated for antidepressant activity using FST after 60 minutes of drug administration on 14th day. Similarly, remaining five groups (6th to 10th) received the same drugs and evaluated using TST after 60 minutes of drug administration. Duration of immobility was noted for six minutes for each rat.Results: One way ANOVA and Tukey Krammer test were used for statistical analysis. The immobility periods were expressed in mean±SD. The immobility period in FST were 207.16±28.7, 50.08±2.9, 46.14±1.2, 40.5±3.4 and 40.0±3.6 seconds respectively for control, standard and three test groups of TFEE (100/200/400 mg/kg). Similarly, immobility periods of 163.11±31.9, 125.03±11.2, 138.81±16.44, 138.16±12.65, 127.58±4.3 seconds were noted for TST for remaining six groups. It was found that TFEE possess statistically significant (p<0.05) antidepressant activity, as evidenced by decrease in the immobility time in both the tests when compared to control group.Conclusions: Present study results demonstrated that TFEE possess antidepressant property in experimental models of depression

Case report-baboon syndrome with paracetamol

Adverse drug reaction (ADR) is defined as “any response to drug which is noxious or unintended and occurs at a dose normally used in man for prophylaxis, diagnosis or treatment of diseases or for modification of physiological function”. Among the ADRs reported, cutaneous drug reactions are most common. Symmetrical drug-related intertriginous and flexural exanthema (SDRIFE), also known as baboon syndrome (BS), is included in the spectrum of systemically induced allergic contact dermatitis. Characteristics of SDRIFE include a sharply defined symmetric erythema in the gluteal area and in the flexural or intertriginous folds without any systemic symptoms or signs. We present a case of 30-year-old female with baboon syndrome after taking the combination of paracetamol and diclofenac. Awareness of SDRIFE (BS) as an unusual drug reaction is especially important since the connection between skin eruption and drug exposure may easily be overlooked or misdiagnosed

Evaluation of analgesic activity of Toxicodendron radicans in animal model using wistar albino rats

Background: Pain forms an integral part of many clinical conditions management is of great importance in every field of medicine. The core of medicine is to preserve and restore patient’s health and to minimize their suffering. Toxicodendron radicans (rhus toxicodendron) is a homoeopathic remedy with anti-inflammatory activity used for various arthritic pain. Rhus toxicodendron is commonly used in skin, mucus membrane affections, pain in joints, tendons, rheumatism in cold season, cellulitis and infection, fever. During the recent exponential rise in the use of alternative medicines and increasing integration into the health service little research has been done on alternative medicine in the context in which it is practiced.Methods: Wistar albino rats were divided into four groups. group 1 received control (normal saline), group 2 received vehicle (alcohol with distilled water in ratio 1:4), and group 3 received standard (diclofenac-10 mg/kg), group 4 and 5 consist of 2 test groups-rhus toxicodendron 30x and 200c respectively. Analgesic activity was assessed using Hot water tail immersion method and Eddy’s hot plate method. Preliminary pilot study was done with 4 doses rhus toxicodendron 6x, 12x, 30x, 200c respectively. Data was analysed by one-way ANOVA followed by Tukey Kramer multiple comparison test. P value <0.05 was considered as significant.Results: In Eddy’s hot plate method, rhus toxicodendron 30 showed increase in paw withdrawal time which was statistically very significant at the end of 1 hr compared to the control group whereas statistically rhus toxicodendron 200 showed extremely significant analgesic property. In hot water tail immersion method rhus toxicodendron 30 showed increase in tail withdrawal time at the end of 1hr compared to the control group which was significant statistically.Conclusions: This study shows that toxicodendron radicans homoeopathic formulations possess significant analgesic property

Anti-inflammatory and antioxidant activity of ethanolic extract of Bauhinia purpurea bark

The aim of this study was to evaluate the anti-inflammatory and antioxidant efficacy of ethanolic extract of Bauhinia purpurea bark (EBP) in Sprague Dawley (SD) rats. Carrageenan induced paw edema and air pouch inflammation, arachidonic acid induced ear edema and complete freund’s adjuvant (CFA) induced hematological alterations were studied in control and experimental rats. Administration of EBP (200mg, 400mg, 600 mg/kg body weight) showed a significant and dose dependent inhibition of paw edema and ear edema and also reversed the hematological alterations near to normalcy. DPPH assay and measurement of MDA levels showed potent antioxidant activity of EBP. With increase in concentration of EBP, improvement in walking scores of motility test confirmed the anti-inflammatory activity of EBP. Acute toxicity studies demonstrated non toxic nature of EBP even at higher doses. Together, our results demonstrate that EBP has potent anti-inflammatory as well as potent antioxidant properties validating the folk medicinal use of this species

Lasers in pediatric dentistry: A review

In ancient Greece, the sun was used in heliotherapy, or the exposure of the body to the sun for the restoration of health. The Chinese used the sun to treat such conditions as rickets, skin cancer and even psychosis. This use of light for treatment of various pathologies is referred to as phototherapy. In 1903, a Danish physician named Niels Finsen developed a technique known as carbon arc phototherapy for the treatment of lupus vulgaris that employed the use of ultraviolet rays

Bilateral supernumerary cusps on deciduous and permanent molars: A case report with a short review

Extra cusps or the central cusps have been recognized as supernumerary cusps by many authors. Extra cusps are usually seen on premolars. Central cusps are of clinical importance as it could be associated with some anomalies that can lead to clinical complications. Extra or accessory cusps rarely pose any problem to the dentist. Even though, it may not cause an emergency in the clinic fracture of this cusp may lead to clinical problems. We present this rare case with bilateral central cusps both on permanent and deciduous molars. Review regarding central cusp, need for continuous follow‑up are also been included

Functional hard-boiled candy formulation employing Plackett Burman design

230-236Plackett-Burman experimental design was employed as a screening experiment with five variables for preparation of hard boiled candy. The effect of varying the levels of hard-boiled candy ingredients such as ratio of liquid glucose (30-40%): sugar (60-70%) addition of nutraceuticals namely green tea extract (0.5-1%) and Amla powder (0.5-1%) along with salt (0.1 to 0.2%) on the physicochemical responses such as hardness, colour, total polyphenol, antioxidant radical scavenging, vitamin C and overall quality were studied. Results indicated that a formulation of: sugar 70%, liquid glucose 30%, amla powder and green tea extract 1% and salt 0.1% was considered as the optimum for obtaining a hard-boiled candy (HBC) with highest overall quality. The present study showed that the hard-boiled candy with added green tea extract and Amla powder were natural sources of polyphenols, vitamin C and antioxidants

Incidence and pathophysiology of diabetes in south Asian adults living in India and Pakistan compared with US blacks and whites

Introduction: We compared diabetes incidence in South Asians aged ≥45 years in urban India (Chennai and Delhi) and Pakistan (Karachi), two low-income and middle-income countries undergoing rapid transition, with blacks and whites in the US, a high-income country.Research design and methods: We computed age-specific, sex-specific and body mass index (BMI)-specific diabetes incidence from the prospective Center for Cardiometabolic Risk Reduction in South Asia Study (n=3136) and the Atherosclerosis Risk in Communities Study (blacks, n=3059; whites, n=9924). We assessed factors associated with incident diabetes using Cox proportional hazards regression.Results: South Asians have lower BMI and waist circumference than blacks and whites (median BMI, kg/m2: 24.9 vs 28.2 vs 26.0; median waist circumference, cm 87.5 vs 96.0 vs 95.0). South Asians were less insulin resistant than blacks and whites (age-BMI-adjusted homeostatic model assessment of insulin resistance, µIU/mL/mmol/L: 2.30 vs 3.45 vs 2.59), and more insulin deficient than blacks but not whites (age-BMI-adjusted homeostasis model assessment of β-cell dysfunction, µIU/mL/mmol/L: 103.7 vs 140.6 vs 103.9). Age-standardized diabetes incidence (cases/1000 person-years (95% CI)) in South Asian men was similar to black men and 1.6 times higher (1.37 to 1.92) than white men (26.0 (22.2 to 29.8) vs 26.2 (22.7 to 29.7) vs 16.1 (14.8 to 17.4)). In South Asian women, incidence was slightly higher than black women and 3 times (2.61 to 3.66) the rate in white women (31.9 (27.5 to 36.2) vs 28.6 (25.7 to 31.6) vs 11.3 (10.2 to 12.3)). In normal weight (BMI \u3c25 kg/m2), diabetes incidence adjusted for age was 2.9 times higher (2.09 to 4.28) in South Asian men, and 5.3 times (3.64 to 7.54) in South Asian women than in white women.Conclusions: South Asian adults have lower BMI and are less insulin resistant than US blacks and whites, but have higher diabetes incidence than US whites, especially in subgroups without obesity. Factors other than insulin resistance (ie, insulin secretion) may play an important role in the natural history of diabetes in South Asians